Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ATM 472 FLUDARABINE CHEMBL1568 CKB 20739657
ATM 472 BINIMETINIB CHEMBL3187723 CKB 28514312
ATM 472 CHEMBL1221601 CHEMBL1221601 inhibitor GuideToPharmacologyInteractions
ATM 472 KU-55933 CHEMBL222102 inhibitor GuideToPharmacologyInteractions
ATM 472 VELIPARIB CHEMBL506871 ClearityFoundationBiomarkers, CKB 27638859, 21300883
ATM 472 OLAPARIB CHEMBL521686 ClearityFoundationBiomarkers, OncoKB, CKB, CGI, CIViC 26510020, 2014, 8, 20739657, 20124459, 24841718, 28363999, 26282658
ATM 472 TALAZOPARIB CHEMBL3137320 ClearityFoundationBiomarkers, CKB 23881923
ATM 472 NIRAPARIB CHEMBL1094636 ClearityFoundationBiomarkers
ATM 472 RUCAPARIB CHEMBL1173055 ClearityFoundationBiomarkers
ATM 472 IRINOTECAN CHEMBL481 CKB, CGI 27638859
ATM 472 QUINPIROLE CHEMBL240773 CGI
ATM 472 VX-970 CHEMBL3545202 CKB 28363999
ATM 472 BENDAMUSTINE CHEMBL487253 CKB 20739657
ATM 472 VALPROIC ACID CHEMBL109 CKB 20739657
ATM 472 AZD-6738 CHEMBL3545178 CKB, CGI 26517239, 26563132
ATM 472 CHEMBL188678 CHEMBL188678 CIViC 23761041
ATM 472 PACLITAXEL CHEMBL428647 CKB 26282658
ATM 472 CHEMBL1086377 CHEMBL1086377 CIViC 23761041
ATM 472 SELUMETINIB CHEMBL1614701 CIViC 27922010
ATM 472 IBRUTINIB CHEMBL1873475 CKB 26563132
ATM 472 VANDETANIB CHEMBL24828 CKB 27683183
ATM 472 TEMOZOLOMIDE CHEMBL810 CGI, CIViC 23960094
ATM 472 TRAMETINIB CHEMBL2103875 CIViC 27922010
ATM 472 AZD-6482 CHEMBL2165191 CKB 26563132
ATM 472 EVEROLIMUS CHEMBL1908360 CKB 27683183

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ATM rs11212617 C metformin efficacy no as measured by decrease in Z score (which includes HbA1c and daily dose of insulin) at 16 weeks, authors report as trend that was not significant after Bonferroni. Allele C is associated with increased response to metformin in people with Diabetes Mellitus, Type 2 as compared to allele A. 29790415 1449564081
ATM rs11212617 C metformin efficacy no in Iranian patients. Response to metformin was defined by HbA1c and fasting blood sugar (FBS) values. Allele C is not associated with response to metformin in people with Diabetes Mellitus, Type 2 as compared to allele A. 27386433 1448123009
ATM rs11212617 A metformin efficacy no The authors evaluated whether women with PCOS would respond to one year of treatment with metformin either with or without oral contraception. Although there was an overall improvement in metabolic measures in subjects due to metformin, this response was not associated with any genetic variant investigated. Allele A is not associated with response to metformin in women with Polycystic Ovary Syndrome as compared to allele C. 28834135 1449147143
ATM rs11212617 C metformin metabolism/PK no Authors state is "close to significance with application of the Bonferroni method" Allele C is associated with decreased concentrations of metformin in people with Diabetes Mellitus, Type 2 as compared to allele A. 29790415 1449563883