PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2E1	1	UBOX5	4	two hybrid	Markson G (2009)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
AKT1	1	ERBB3	3	affinity chromatography technology	Kim CK (2011)	1
NDFIP2	2	EGFR	5	affinity chromatography technology	Mund T (2010)	1
ADRB2	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Han SO (2012)	2
NEDD4	2	DDX54	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
NTRK1	1	PDGFRB	8	affinity chromatography technology	Emdal KB (2015)	1
ADRB2	0	ARRDC1	4	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Patwari P (2011)	2
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
FAM189B	2	SMO	0	affinity chromatography technology	Huttlin EL (2017)	1
WBP2	0	CUEDC1	4	two hybrid	Lim SK (2016)	1
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
NTRK1	1	IRS2	6	affinity chromatography technology	Emdal KB (2015)	1
ERBB3	3	MDM2	2	affinity chromatography technology, affinity chromatography technology	Kim CK (2011), Kim CK (2011)	2
RAPGEF2	5	NEDD4	2	affinity chromatography technology, pull down, affinity chromatography technology	Pham N (2001), Pham N (2001), Zhang H (2013)	3
BTRC	1	UBE2D1	0	affinity chromatography technology	Fernandez-Sanchez ME (2010)	1
FGFR2	6	FGFR1	2	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	PSMD4	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, pull down	Kulikov R (2010), Kulikov R (2010), Uchiki T (2009), Dolezelova P (2012), Kim HT (2012), Sparks A (2014)	6
NEDD4	2	SGK1	4	pull down, pull down, enzymatic study, affinity chromatography technology	Asher C (2003), Snyder PM (2002), Persaud A (2009), Wiemuth D (2010)	4
ERBB3	3	PTEN	24	two hybrid	Yao Z (2017)	1
SRC	2	PDGFRB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee CW (2007), Collin G (2007), Wu CY (2008)	3
PLK1	0	CDC25C	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Roshak AK (2000), Izumi H (2009), Izumi H (2009), Yun SM (2009)	4
BTRC	1	UBE2D3	1	pull down	Chong RA (2014)	1
RNF11	0	CBLB	3	two hybrid	Colland F (2004)	1
ARRDC3	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Han SO (2012)	2
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
PPARG	0	SMAD3	1	affinity chromatography technology	Lin LC (2011)	1
UBE2D1	0	RNF7	0	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Yasukawa T (2008), Zakaria R (2013), Kuang Z (2010), Lamsoul I (2011), Heuze ML (2008), Kershaw NJ (2014), Uematsu K (2016), Lo JY (2017)	9
MLANA	2	NEDD4	2	affinity chromatography technology, pull down	Levy F (2005), Levy F (2005)	2
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
RAC1	7	NEDD4	2	affinity chromatography technology, pull down	Nethe M (2012), Nethe M (2012)	2
SGK1	4	RAP2A	0	affinity chromatography technology	Huttlin EL (2015)	1
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
RAC1	7	LATS1	3	two hybrid	Bandyopadhyay S (2010)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
SCNN1A	1	SCNN1G	2	affinity chromatography technology	Buck TM (2017)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
NTRK1	1	RPAP3	1	affinity chromatography technology	Emdal KB (2015)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
TMEM51	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNCA	0	SLC6A3	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wersinger C (2003), Wersinger C (2003), Lee FJ (2001), Lee FJ (2001), Wersinger C (2003), Wersinger C (2003), Wersinger C (2004), Wersinger C (2004), Wersinger C (2005), Wersinger C (2005)	10
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
SCN5A	9	NEDD4	2	pull down, enzymatic study	van Bemmelen MX (2004), van Bemmelen MX (2004)	2
PTEN	24	AMOT	6	affinity chromatography technology	Maddika S (2011)	1
KCNQ1	5	NEDD4	2	affinity chromatography technology, imaging technique	Krzystanek K (2011), Krzystanek K (2011)	2
SCNN1B	1	HGS	5	affinity chromatography technology	Zhou R (2010)	1
SMURF2	3	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Kim S (2010), Nie J (2010), Lu K (2011), Maspero E (2013), Kristariyanto YA (2015), Mari S (2014), Emanuelli A (2017)	7
SMAD3	1	HGS	5	affinity chromatography technology	Miura S (2000)	1
NEDD4	2	RANBP10	0	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
SMURF2	3	UBE2L3	1	pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Ogunjimi AA (2005), Kim S (2010), Ogunjimi AA (2005), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016)	7
CFTR	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Caohuy H (2009), Caohuy H (2014)	2
PTEN	24	EGFR	5	affinity chromatography technology	Zheng J (2016)	1
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
SCNN1G	2	NEDD4	2	pull down, pull down, far western blotting, enzymatic study, affinity chromatography technology	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Woelk T (2006), Snyder PM (2001)	5
FGFR2	6	ERRFI1	1	two hybrid	Arroyo R (2015)	1
SNCA	0	AKT1	1	affinity chromatography technology, far western blotting	Chung JY (2011), Chung JY (2011)	2
TNK2	7	NTRK1	1	affinity chromatography technology, affinity chromatography technology	La Torre A (2013), La Torre A (2013)	2
NEDD4	2	GRIA1	5	affinity chromatography technology, affinity chromatography technology	Lin A (2011), Schwarz LA (2010)	2
SCAMP3	0	NEDD4	2	two hybrid, affinity chromatography technology	Aoh QL (2009), Aoh QL (2009)	2
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
SRC	2	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schmidt MH (2005), Schmidt MH (2005), Zhou X (2010), Zhou X (2010)	4
EGFR	5	MAP3K3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PDCD6IP	3	PDGFRB	8	affinity chromatography technology	Lennartsson J (2006)	1
HGS	5	LITAF	0	two hybrid	Rolland T (2014)	1
IFITM3	0	FYN	1	affinity chromatography technology	Jia R (2012)	1
EGFR	5	SNCA	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
UBE2D2	0	RNF7	0	two hybrid, pull down	Markson G (2009), Kershaw NJ (2014)	2
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
AKT1	1	RNF11	0	enzymatic study	Connor MK (2005)	1
NEDD4	2	MAP3K2	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
NEDD4	2	FGFR2	6	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
ADRB2	0	SRC	2	affinity chromatography technology	Cao W (2000)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
UBE2D3	1	MGRN1	4	two hybrid	Markson G (2009)	1
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
FGFR1	2	SRC	2	affinity chromatography technology, affinity chromatography technology	Dudka AA (2010), Vecchione A (2007)	2
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
PDGFRB	8	PTEN	24	imaging technique	Chen TC (2014)	1
SLC11A2	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Howitt J (2009), Howitt J (2009)	2
NEDD4	2	PPARG	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Han L (2013), Han L (2013), Han L (2013)	3
ARRB2	5	RTF1	3	affinity chromatography technology	Huttlin EL (2017)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
EGFR	5	ERRFI1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2009), Pao-Chun L (2009), Tong J (2008), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013), Park E (2015), Park E (2015), Park E (2015), Park E (2015), Yao Z (2017)	12
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
LDLRAD4	1	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	LAPTM4B	1	affinity chromatography technology, affinity chromatography technology	Milkereit R (2011), Tan X (2015)	2
LITAF	0	FGFR2	6	affinity chromatography technology	Huttlin EL (2017)	1
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
ADRB2	0	ARRDC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Nabhan JF (2010), Shea FF (2012), Qi S (2014), Patwari P (2011), Shea FF (2012), Tian X (2016), Tian X (2016), Tian X (2016)	8
NEDD4	2	CCNH	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Hong SW (2013), Hong SW (2013), Hong SW (2013), Hong SW (2013), Hong SW (2013)	5
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
NTRK1	1	HGS	5	affinity chromatography technology	Emdal KB (2015)	1
SMO	0	NEDD4	2	affinity chromatography technology, two hybrid	Luo QF (2012), Luo QF (2012)	2
SRC	2	5430	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
LATS1	3	PTEN	24	enzymatic study	Chiyoda T (2012)	1
NEDD4	2	RPAP3	1	pull down, pull down	Persaud A (2009), Ingham RJ (2005)	2
THOC1	1	NEDD4	2	affinity chromatography technology, enzymatic study	Song F (2013), Song F (2013)	2
NEDD4	2	CDK5	0	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
PPARG	0	SMAD2	5	affinity chromatography technology	Lu D (2013)	1
MAP1LC3B	1	UBC	7	imaging technique	Liu X (2017)	1
UBC	7	AMOT	6	affinity chromatography technology	Matsumoto M (2005)	1
JUN	0	NEDD4	2	two hybrid, affinity chromatography technology	Camus G (2007), Camus G (2007)	2
NEDD4	2	ABL1	9	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
NEDD4	2	LAPTM5	3	affinity chromatography technology, enzymatic study, two hybrid	Pak Y (2006), Persaud A (2009), Colland F (2004)	3
LITAF	0	FGFR1	2	affinity chromatography technology	Huttlin EL (2017)	1
PSMD4	1	GJA1	0	affinity chromatography technology	Su V (2013)	1
MTMR4	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, pull down	Plant PJ (2009), Plant PJ (2009), Plant PJ (2009)	3
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
ERBB3	3	HGS	5	affinity chromatography technology, affinity chromatography technology	Fosdahl AM (2017), Fosdahl AM (2017)	2
NEDD4	2	ERG	1	affinity chromatography technology, affinity chromatography technology	Albesa M (2011), Albesa M (2011)	2
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
BTRC	1	PSMD4	1	enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012)	2
WBP2	0	EGFR	5	affinity chromatography technology	Lim SK (2016)	1
EGFR	5	PSMD4	1	protein complementation assay	Deribe YL (2009)	1
FGFR1	2	ERBB3	3	unspecified method	Jones RB (2006)	1
SMURF2	3	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Jeong HM (2014), Jeong HM (2014), Jeong HM (2014), Jeong HM (2014)	4
TNK2	7	NEDD4	2	affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology	Lin Q (2010), Lin Q (2010), Lin Q (2010), Lin Q (2010), Hitomi Y (2013)	5
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
TTYH2	2	IGF1R	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
BECN1	2	NEDD4	2	affinity chromatography technology, pull down, two hybrid, enzymatic study, affinity chromatography technology	Platta HW (2012), Platta HW (2012), Platta HW (2012), Platta HW (2012), Verma N (2017)	5
WBP1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF2	3	CUEDC1	4	two hybrid	Colland F (2004)	1
NEDD4	2	YY1	7	enzymatic study, affinity chromatography technology	Persaud A (2009), Persaud A (2009)	2
UBC	7	ABL1	9	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
LDLRAD4	1	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LITAF	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shirk AJ (2005), Li W (2015), Huttlin EL (2017)	3
ARRB2	5	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Luan B (2009), Kim YM (2002), Lee J (2013)	4
GJA1	0	HGS	5	imaging technique	Leithe E (2009)	1
AKT1	1	ARRB2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Beaulieu JM (2008), Beaulieu JM (2008), Lodeiro M (2009), Luan B (2009)	4
ARRDC1	4	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	CUEDC1	4	pull down	Zhang X (2017)	1
PTEN	24	UBE2L3	1	affinity chromatography technology	Waite KA (2003)	1
PIP5K1C	4	LAPTM4B	1	affinity chromatography technology, affinity chromatography technology, pull down	Tan X (2015), Tan X (2015), Tan X (2015)	3
NEDD4	2	PTEN	24	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wang X (2008), Wang X (2008), Yim EK (2009), Chung S (2011), Wu Y (2013), Hong SW (2013), Hong SW (2013), Li N (2015), Li Z (2014), Chen Z (2016), Ahn Y (2008)	11
NTRK1	1	IGF1R	5	affinity chromatography technology	Emdal KB (2015)	1
NEDD4	2	GUCD1	0	affinity chromatography technology, affinity chromatography technology	Bellet MM (2014), Bellet MM (2014)	2
UBE2E1	1	NEDD4	2	enzymatic study, pull down, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, pull down	Anan T (1998), Malakhova OA (2008), Malakhova OA (2008), Woelk T (2006), Sarkari F (2013), Sarkari F (2013), Sugeno N (2014), Zhang X (2017)	8
IGF1R	5	ARRB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Broussas M (2009), Girnita L (2005), Girnita L (2005), Zheng H (2012)	4
SAV1	0	AMOT	6	bioid	Couzens AL (2013)	1
PLK1	0	SNCA	0	enzymatic study	Mbefo MK (2010)	1
BTRC	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
LDLRAD4	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	PDCD6IP	3	affinity chromatography technology	Emdal KB (2015)	1
AP1G2	4	NEDD4	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rost M (2008), Rost M (2008), Rost M (2008)	3
NEDD4	2	IRS2	6	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down	Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015)	5
BECN1	2	SMAD2	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SRC	2	SNCA	0	enzymatic study	Ellis CE (2001)	1
UBE2D2	0	MGRN1	4	two hybrid	Markson G (2009)	1
NEDD4	2	IFITM3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chesarino NM (2015), Chesarino NM (2015), Chesarino NM (2015)	3
SCNN1B	1	SCNN1G	2	protein complementation assay	Faria D (2012)	1
NEDD4	2	CBLB	3	pull down, affinity chromatography technology, affinity chromatography technology	Magnifico A (2003), Magnifico A (2003), Magnifico A (2003)	3
EGFR	5	TNK2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Lin Q (2010), Pao-Chun L (2009), Shen F (2007), Howlin J (2008), Howlin J (2008), Tong J (2008), Jones S (2014), Jones S (2014), Chua BT (2010)	9
ADRB2	0	MAP1LC3B	1	affinity chromatography technology	Kommaddi RP (2015)	1
ARRB2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Han SO (2012)	2
CBLB	3	UBE2D2	0	x-ray crystallography	Kobashigawa Y (2011)	1
SPRY2	4	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SAV1	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Bae SJ (2015), Bae SJ (2015), Bae SJ (2015), Bae SJ (2015), Bae SJ (2015)	5
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
SRC	2	MDM2	2	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	5
UBE2D1	0	MGRN1	4	two hybrid, pull down	Markson G (2009), Kim BY (2007)	2
LATS1	3	NEDD4	2	unspecified method, affinity chromatography technology, enzymatic study	Salah Z (2013), Salah Z (2013), Salah Z (2013)	3
MDM2	2	LATS1	3	affinity chromatography technology	Matallanas D (2011)	1
FGFR1	2	NEDD4	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Persaud A (2011), Persaud A (2011), Persaud A (2009), Persaud A (2014)	4
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
SRC	2	ERRFI1	1	enzymatic study	Park E (2015)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
EGFR	5	PDGFRB	8	affinity chromatography technology	Habib AA (1998)	1
MDM2	2	JUN	0	pull down	Miyamoto-Sato E (2010)	1
FAM189A2	2	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF11	0	SMURF2	3	pull down, affinity chromatography technology, two hybrid, two hybrid	Subramaniam V (2003), Santonico E (2010), Colland F (2004), Colland F (2004)	4
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
PPARG	0	JUN	0	unspecified method	Lee G (2002)	1
ARRB2	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, two hybrid, affinity chromatography technology	Wang P (2003), Wang P (2003), Wang P (2003), Shenoy SK (2008), Shenoy SK (2001), Ahmed MR (2011), Yin C (2011), Yin C (2011), Yin C (2011), Girnita L (2005), Girnita L (2005), Nogues L (2011), Boularan C (2007), Boularan C (2007), Wang J (2011), Shenoy SK (2001), Zheng M (2015)	17
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
TMEM92	0	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	PDGFRB	8	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
FYN	1	CBLB	3	two hybrid	Grossmann A (2015)	1
TMEM171	1	TTYH3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
NTRK1	1	5430	0	affinity chromatography technology	Emdal KB (2015)	1
LDLRAD4	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TTYH3	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	He Y (2008), He Y (2008)	2
PTEN	24	AKT1	1	affinity chromatography technology, fluorescent resonance energy transfe	Mistafa O (2010), Ivanov AA (2017)	2
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
SMAD2	5	YY1	7	pull down, affinity chromatography technology	Kurisaki K (2003), Brown KA (2008)	2
MGRN1	4	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Gunn TM (2012), Gunn TM (2012)	2
SMAD7	1	AKT1	1	affinity chromatography technology	Song K (2006)	1
NTRK1	1	PLK1	0	affinity chromatography technology	Emdal KB (2015)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
NEDD4	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Vina-Vilaseca A (2010), Sehat B (2008), Platta HW (2012), Tofaris GK (2011), Uchiki T (2009), Liu PY (2012), Sugeno N (2014), Kim HT (2007), Chen Z (2016)	9
UBE2D2	0	BTRC	1	enzymatic study	Cenciarelli C (1999)	1
EGFR	5	PLK1	0	affinity chromatography technology	Tong J (2014)	1
PTEN	24	PLK1	0	affinity chromatography technology, enzymatic study	Li Z (2014), Li Z (2014)	2
IGF1R	5	NEDD4	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Vecchione A (2003), Sehat B (2008), Broussas M (2009)	3
FAM189A2	2	FAM189B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	AP1G2	4	affinity chromatography technology	Foerster S (2013)	1
LDLRAD4	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIP5K1C	4	NEDD4	2	pull down, affinity chromatography technology	Sun M (2016), Sun M (2016)	2
LAPTM5	3	SMURF2	3	two hybrid, two hybrid	Colland F (2004), Colland F (2004)	2
UBE2L3	1	SMAD7	1	unspecified method	Ogunjimi AA (2005)	1
TNK2	7	PDGFRB	8	affinity chromatography technology, affinity chromatography technology, enzymatic study	Pao-Chun L (2009), Zhang J (2015), Zhang J (2015)	3
TNK2	7	FGFR1	2	affinity chromatography technology, affinity chromatography technology, pull down	Hu F (2016), Hu F (2016), Hu F (2016)	3
UBE2E1	1	RNF11	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
NEDD4	2	AMOT	6	affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2012), Wang C (2012), Wang C (2012)	3
ERBB4	5	MDM2	2	affinity chromatography technology	Gilmore-Hebert M (2010)	1
SAV1	0	LATS1	3	affinity chromatography technology	Guo C (2007)	1
NEDD4	2	TNIK	4	pull down, pull down, affinity chromatography technology	Kawabe H (2010), Wang L (2017), Wang L (2017)	3
PPARG	0	MDM2	2	affinity chromatography technology	Xu Y (2016)	1
NTRK1	1	CDK5	0	affinity chromatography technology	Emdal KB (2015)	1
NEDD4	2	PMEPA1	1	pull down, affinity chromatography technology, enzymatic study, two hybrid	Xu LL (2003), Xu LL (2003), Luo S (2017), Luo S (2017)	4
PSMD4	1	RTF1	3	genetic interference	Horlbeck MA (2018)	1
UBE2D3	1	UBOX5	4	two hybrid, pull down	Markson G (2009), Hatakeyama S (2001)	2
NEDD4	2	NEDD4	2	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Malakhova OA (2008), Kenten JH (2005), Ingham RJ (2005), Hong SW (2013), Persaud A (2014), Persaud A (2014), Anindya R (2007), Hoeller D (2007), Moessinger J (2012), Wiesner S (2007), Ernst A (2013), Mari S (2014), Zhang W (2016), Kim HT (2007), Attali I (2017), Wu W (2015), Qiu Y (2017), Byrne R (2017), Chen Z (2017)	19
WBP2	0	UBC	7	two hybrid	Lim SK (2016)	1
MAP1LC3B	1	NEDD4	2	affinity chromatography technology, pull down, pull down, x-ray crystallography	Sun A (2017), Sun A (2017), Qiu Y (2017), Qiu Y (2017)	4
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
SCNN1B	1	NEDD4	2	pull down, pull down, far western blotting, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Persaud A (2009), Ke Y (2010), Snyder PM (2001), Kanelis V (2001)	7
SLC6A3	6	NEDD4	2	affinity chromatography technology, enzymatic study	Sorkina T (2006), Vina-Vilaseca A (2010)	2
FAM189A2	2	GJA1	0	affinity chromatography technology	Huttlin EL (2015)	1
MDM2	2	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sui G (2004), Sui G (2004), Sui G (2004), Dolezelova P (2012)	4
PDCD6IP	3	ARRDC1	4	pull down, two hybrid, two hybrid	Rauch S (2011), Rauch S (2011), Rauch S (2011)	3
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
NEDD4	2	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
SCNN1B	1	SGK1	4	affinity chromatography technology	Ke Y (2010)	1
FYN	1	SNCA	0	enzymatic study, enzymatic study, enzymatic study	Nakamura T (2001), Payton JE (2004), Ellis CE (2001)	3
SRC	2	LATS1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Si Y (2017), Si Y (2017), Si Y (2017)	3
CDK5	0	PPARG	0	affinity chromatography technology, enzymatic study	Li P (2011), Amato AA (2012)	2
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
BTRC	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
5430	0	UBE2L3	1	pull down	Anindya R (2007)	1
EGFR	5	SMURF2	3	affinity chromatography technology, affinity chromatography technology, pull down	Ray D (2011), Ray D (2011), Ray D (2011)	3
RAPGEF2	5	UBC	7	affinity chromatography technology	Kim TY (2014)	1
TMEM92	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HGS	5	SCAMP3	0	affinity chromatography technology	Aoh QL (2009)	1
MDM2	2	IGF1R	5	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Sehat B (2008), Sehat B (2008), Girnita L (2003), Girnita L (2003), Broussas M (2009), Chen TC (2014), Worrall C (2017)	7
ARRDC3	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
SMAD2	5	AKT1	1	affinity chromatography technology	Song K (2006)	1
LDLRAD4	1	FGFR1	2	affinity chromatography technology	Huttlin EL (2015)	1
FYN	1	TNK2	7	affinity chromatography technology, pull down	Linseman DA (2001), Linseman DA (2001)	2
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
SCNN1A	1	HGS	5	affinity chromatography technology, affinity chromatography technology	Zhou R (2010), Zhou R (2010)	2
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
ARRDC3	0	HGS	5	affinity chromatography technology	Han SO (2012)	1
NEDD4	2	SRC	2	affinity chromatography technology, pull down, enzymatic study	Persaud A (2014), Persaud A (2014), Persaud A (2014)	3
UBE2L3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Bruce MC (2008), Wiesner S (2007), Vina-Vilaseca A (2010), Anindya R (2007), Lin Q (2010), Chung S (2011), Tofaris GK (2011), Han L (2013), Persaud A (2014), Uchiki T (2009), Miyazaki K (2003), Zhang W (2016), Zhang X (2017)	14
NEDD4	2	SFTPC	0	pull down, affinity chromatography technology	Kotorashvili A (2009), Kotorashvili A (2009)	2
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
PDCD6IP	3	ARRDC3	0	two hybrid	Rauch S (2011)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
MDM2	2	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Lin HK (2002), Ogawara Y (2002), Zhou BP (2001), Zhou BP (2001), Kim CK (2011), Kim CK (2011), Zhu QS (2011), Milne D (2004), Deep G (2008), Deep G (2008), Chen TC (2014)	11
NEDD4	2	RAP2A	0	pull down, pull down, affinity chromatography technology	Kawabe H (2010), Wang L (2017), Wang L (2017)	3
NEDD4	2	PSMD4	1	enzymatic study, enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012), Puig-Sarries P (2015)	3
FAM189A2	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM52B	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB2	5	UBC	7	affinity chromatography technology, fluorescent resonance energy transfe	Xiao K (2007), Dalrymple MB (2011)	2
ARRDC3	0	NEDD4	2	affinity chromatography technology, imaging technique, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Nabhan JF (2010), Qi S (2014), Qi S (2014), Qi S (2014), Huttlin EL (2017)	6
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
TRPV6	0	NEDD4	2	affinity chromatography technology, pull down	Zhang W (2010), Zhang W (2010)	2
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
FGFR2	6	HGS	5	affinity chromatography technology, imaging technique	Belleudi F (2009), Belleudi F (2009)	2
UBE2D3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down	Anan T (1998), Wang X (2008), Maspero E (2011), Katz M (2002), Wu K (2011), Maspero E (2013), Hong SW (2013), Zhou W (2014), Sugeno N (2014), Maspero E (2013), Miyazaki K (2003), Mari S (2014), Song F (2013), Fan CD (2013)	14
CDK5	0	CDC25C	0	enzymatic study	Chang KH (2012)	1
NTRK1	1	ABL1	9	two hybrid, affinity chromatography technology, pull down	Koch A (2000), Yano H (2000), Koch A (2000)	3
FAM189B	2	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
UBOX5	4	UBE2L3	1	two hybrid, pull down, two hybrid	Pringa E (2001), Pringa E (2001), Markson G (2009)	3
EGFR	5	5430	0	affinity chromatography technology	Yao Z (2017)	1
SRC	2	ERBB3	3	unspecified method	Jones RB (2006)	1
NEDD4	2	RNF7	0	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Persaud A (2009), Zhou W (2014), Zhou W (2014), Zhou W (2014)	4
UBC	7	SGK1	4	pull down	Nathan JA (2013)	1
RPAP3	1	5430	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2017)	2
MDM2	2	UBE2L3	1	pull down, pull down	Hampe C (2006), Yamauchi T (2014)	2
SMURF2	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
FYN	1	FGFR2	6	affinity chromatography technology	Kaabeche K (2004)	1
NEDD4	2	ERBB4	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zeng F (2009), Zeng F (2009), Zeng F (2009)	3
SRC	2	TNK2	7	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Chan W (2009), Modzelewska K (2006), Chan W (2011), Chan W (2011), Chan W (2011), Yokoyama N (2003)	6
SMAD1	0	HGS	5	affinity chromatography technology	Miura S (2000)	1
NEDD4	2	NTRK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Arevalo JC (2006), Arevalo JC (2006), Arevalo JC (2006), Georgieva MV (2011), Georgieva MV (2011), Persaud A (2009), Persaud A (2009), Emdal KB (2015)	8
NEDD4	2	AKT3	3	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
NEDD4	2	FYN	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
MDM2	2	ADRB2	0	enzymatic study	Shenoy SK (2001)	1
ERBB3	3	NEDD4	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Huang Z (2014), Huang Z (2014), Huang Z (2014), Verma N (2017)	4
PIP5K1C	4	UBC	7	affinity chromatography technology	Li X (2013)	1
SNCA	0	UBC	7	fluorescent resonance energy transfe, affinity chromatography technology	Sharma N (2001), Nemes Z (2009)	2
BECN1	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RNF7	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Tan M (2010), Kuang P (2016), Kuang P (2016), Kuang P (2016)	4
PSMD4	1	ABL1	9	biochemical	Liu X (2006)	1
EGFR	5	CDC25C	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PLK1	0	MDM2	2	enzymatic study, affinity chromatography technology, pull down	Dias SS (2009), Dias SS (2009), Dias SS (2009)	3
PDGFRB	8	CBLB	3	affinity chromatography technology	Rorsman C (2016)	1
NEDD4	2	CAMK1D	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
ERG	1	JUN	0	pull down, pull down	Verger A (2001), Verger A (2001)	2
NEDD4	2	PLK1	0	pull down, enzymatic study	Persaud A (2009), Li Z (2014)	2
ARRDC1	4	NEDD4	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rauch S (2011), Huttlin EL (2015), Huttlin EL (2017)	3
SMURF2	3	BTRC	1	enzymatic study, affinity chromatography technology	Shukla S (2014), Shukla S (2014)	2
TTYH2	2	NEDD4	2	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	He Y (2008), He Y (2008), He Y (2008), He Y (2008)	4
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
UBE2D1	0	UBOX5	4	two hybrid	Markson G (2009)	1
ABL1	9	CBLB	3	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	CBLB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Schulze WX (2006), Ettenberg SA (1999), Davies GC (2006), Davies GC (2006), Tong J (2009), Ettenberg SA (2001), Tong J (2008), Levkowitz G (1999), Tong J (2014)	9
SMAD1	0	YY1	7	pull down	Kurisaki K (2003)	1
NEDD4	2	5430	0	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Anindya R (2007), Anindya R (2007), Ingham RJ (2005), Beaudenon SL (1999)	4
NTRK1	1	SCAMP3	0	affinity chromatography technology	Emdal KB (2015)	1
CCNH	3	5430	0	enzymatic study, biochemical, enzymatic study	Chen R (2004), Nekhai S (1997), Lolli G (2004)	3
EGFR	5	TNIK	4	affinity chromatography technology	Yao Z (2017)	1
ERBB3	3	CDC25C	0	two hybrid	Yao Z (2017)	1
SMAD2	5	HGS	5	affinity chromatography technology	Miura S (2000)	1
ADRB2	0	HGS	5	affinity chromatography technology	Shea FF (2012)	1
MAP3K2	1	MAP3K3	3	pull down, affinity chromatography technology	Takeda AN (2014), Hein MY (2015)	2
NDFIP2	2	FYN	1	affinity chromatography technology	Mund T (2010)	1
EGFR	5	CDK5	0	affinity chromatography technology	Tong J (2014)	1
PAX7	3	NEDD4	2	affinity chromatography technology, pull down, enzymatic study	Bustos F (2015), Bustos F (2015), Bustos F (2015)	3
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
SCNN1A	1	NEDD4	2	pull down, pull down, far western blotting, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Snyder PM (2001), Bobby R (2013), Panwalkar V (2016), Panwalkar V (2016)	7
EGFR	5	KCNQ1	5	affinity chromatography technology	Yao Z (2017)	1
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
GJA1	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kimura K (2010), Girao H (2009), Girao H (2009)	3
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
NDFIP2	2	SRC	2	affinity chromatography technology	Mund T (2010)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
SLC11A2	2	NDFIP2	2	affinity chromatography technology	Foot NJ (2008)	1
AKT3	3	AKT1	1	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	UBOX5	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
ERG	1	5430	0	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
NTRK1	1	RTF1	3	affinity chromatography technology	Emdal KB (2015)	1
NEDD4	2	RTF1	3	enzymatic study, pull down, affinity chromatography technology	Persaud A (2009), Persaud A (2009), Persaud A (2009)	3
UBC	7	MYCN	2	affinity chromatography technology	Yu F (2014)	1
TMEM171	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLC5A7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Yamada H (2012), Yamada H (2012)	2
SMAD3	1	YY1	7	pull down, affinity chromatography technology	Kurisaki K (2003), Brown KA (2008)	2
SMURF2	3	UBE2D1	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down	Kim S (2010), Shukla S (2014), Shukla S (2014), Shukla S (2014), Kristariyanto YA (2015)	5
TMEM51	2	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
WBP1	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
UBE2D2	0	RNF11	0	two hybrid, two hybrid, pull down, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Colland F (2004), Markson G (2009)	5
TMEM52B	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
RAC1	7	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
ERRFI1	1	PDGFRB	8	affinity chromatography technology	Pao-Chun L (2009)	1
MAP1LC3B	1	UBE2L3	1	two hybrid, affinity chromatography technology	Gandini MA (2014), Gandini MA (2014)	2
PPARG	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu Y (2016), Xu Y (2016), Xu Y (2016)	3
UBE2D2	0	UBOX5	4	two hybrid	Markson G (2009)	1
RNF11	0	PDCD6IP	3	two hybrid	Colland F (2004)	1
NEDD4	2	FLT1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
EGFR	5	SCAMP3	0	affinity chromatography technology	Tong J (2014)	1
JUN	0	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology	Xie M (2010), Chen C (2008), Chen C (2008)	3
MYCN	2	NEDD4	2	affinity chromatography technology, enzymatic study	Liu PY (2012), Liu PY (2012)	2
NEDD4	2	MAP3K3	3	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
SCNN1B	1	SCNN1A	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012), Buck TM (2017)	4
LAPTM4B	1	HGS	5	affinity chromatography technology	Tan X (2015)	1
NEDD4	2	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology	Sette P (2010), Sette P (2010)	2
HGS	5	SPRY2	4	affinity chromatography technology	Kim HJ (2007)	1
PTEN	24	UBE2D1	0	genetic interference	Vizeacoumar FJ (2013)	1
NDFIP2	2	PTEN	24	affinity chromatography technology	Mund T (2010)	1
PPARG	0	UBC	7	enzymatic study	Hou Y (2012)	1
EGFR	5	IRS2	6	affinity chromatography technology	Tong J (2008)	1
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
ERBB4	5	CDC25C	0	two hybrid	Yao Z (2017)	1
LATS1	3	PLK1	0	affinity chromatography technology	Chiyoda T (2012)	1
EGFR	5	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
ADRB2	0	UBC	7	affinity chromatography technology	Roy SJ (2013)	1
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
ADRB2	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kittanakom S (2014), Tian X (2016), Tian X (2016)	3
FGFR1	2	AKT1	1	affinity chromatography technology, affinity chromatography technology	Hu F (2016), Hu F (2016)	2
ERRFI1	1	NEDD4	2	affinity chromatography technology, pull down, enzymatic study	Sun M (2016), Sun M (2016), Sun M (2016)	3
UBC	7	CBLB	3	pull down, pull down, pull down, pull down, enzymatic study	De Schutter J (2009), Fenner BJ (2009), Zhou ZR (2008), Raasi S (2005), Kim M (2004)	5
FAM189B	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKT1	1	RAC1	7	enzymatic study	Kwon T (2000)	1
NEDD4	2	ANXA13	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Plant PJ (2000), Plant PJ (2000), Plant PJ (2000), Plant PJ (2000)	4
NEDD4	2	WBP2	0	enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Persaud A (2009), Persaud A (2009), Persaud A (2009), Ingham RJ (2005), Kathman SG (2015), Qiu Y (2017)	6
BTRC	1	RAPGEF2	5	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Kim TY (2014), Kim TY (2014), Loveless TB (2015), Low TY (2014)	6
NEDD4	2	TRIM52	0	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
TMEM255A	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM189A2	2	TTYH3	1	affinity chromatography technology	Huttlin EL (2015)	1
NEDD4	2	SNCA	0	enzymatic study, affinity chromatography technology, enzymatic study	Tofaris GK (2011), Tofaris GK (2011), Sugeno N (2014)	3
RNF7	0	UBE2D3	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tan M (2010), Kershaw NJ (2014), Raducu M (2016), Kuang P (2016), Kuang P (2016)	5
RNF11	0	HGS	5	affinity chromatography technology	Kostaras E (2012)	1
SMAD2	5	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Miyamoto-Sato E (2010)	2
NDFIP2	2	NEDD4	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Cristillo AD (2003), Cristillo AD (2003), Shearwin-Whyatt LM (2004), Woelk T (2006), Ohzono C (2010), Persaud A (2009), Persaud A (2009), Konstas AA (2002)	8
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
NEDD4	2	CDC25C	0	affinity chromatography technology, unspecified method	Lu PJ (1999), Lu PJ (1999)	2
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
NTRK1	1	PSMD4	1	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	LAPTM5	3	pull down	Pak Y (2006)	1
UBE2E1	1	MGRN1	4	two hybrid	Markson G (2009)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
LATS1	3	AMOT	6	bioid, enzymatic study, affinity chromatography technology	Couzens AL (2013), Adler JJ (2013), Hauri S (2013)	3
RNF11	0	PSMD4	1	affinity chromatography technology	Poulsen SL (2013)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
SMAD1	0	UBC	7	two hybrid	Guo X (2001)	1
UBC	7	PDCD6IP	3	pull down	Zhang X (2017)	1
NEDD4	2	GRIN2D	1	affinity chromatography technology, affinity chromatography technology	Gautam V (2013), Gautam V (2013)	2
SPRY2	4	NEDD4	2	affinity chromatography technology, affinity chromatography technology, pull down	Edwin F (2010), Edwin F (2010), Edwin F (2010)	3
FGFR2	6	SRC	2	affinity chromatography technology	Schueller AC (2008)	1
PMEPA1	1	HGS	5	two hybrid, affinity chromatography technology, pull down	Luo S (2017), Luo S (2017), Luo S (2017)	3
TNK2	7	AKT1	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhang J (2015), Zhang J (2015), Hu F (2016)	3
LATS1	3	SMURF2	3	unspecified method	Salah Z (2013)	1
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
ABL1	9	MDM2	2	affinity chromatography technology, pull down, enzymatic study, unspecified method, enzymatic study	Goldberg Z (2002), Goldberg Z (2002), Goldberg Z (2002), Batuello CN (2015), Batuello CN (2015)	5
CFTR	5	PSMD4	1	affinity chromatography technology	Pankow S (2015)	1
NEDD4	2	H3F3A	1	enzymatic study, affinity chromatography technology	Zhang X (2017), Zhang X (2017)	2
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
ABL1	9	ERBB4	5	unspecified method	Jones RB (2006)	1
ABL1	9	ERBB3	3	unspecified method	Jones RB (2006)	1
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6
JUN	0	UBC	7	two hybrid, protein complementation assay	Bandyopadhyay S (2010), Fang D (2004)	2
NTRK1	1	CBLB	3	affinity chromatography technology, affinity chromatography technology	Emdal KB (2015), Emdal KB (2015)	2