PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NEK2	2	CEP250	4	two hybrid, enzymatic study, affinity chromatography technology	Fry AM (1998), Fry AM (1998), Fogeron ML (2013)	3
PPP1CC	2	TPM3	0	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Sarraf SA (2013), Huttlin EL (2017)	3
NEK2	2	EIF4A2	4	two hybrid	Vinayagam A (2011)	1
PPP1CA	3	PPP1R2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Esteves SL (2012), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	7
SMURF1	4	NEK2	2	enzymatic study	Andrews PS (2010)	1
DCTN1	6	NDC80	4	bioid	Gupta GD (2015)	1
PPP1CC	2	PPP1R2	2	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Helps NR (1994), Fardilha M (2011), Huttlin EL (2015), Wan C (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	9
BUB1B	0	NDC80	4	affinity chromatography technology	So J (2015)	1
BUB1B	0	NEK2	2	affinity chromatography technology	Boekhout M (2015)	1
VCP	6	CHEK1	2	affinity chromatography technology	Yu CC (2013)	1
CDC27	2	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Hein MY (2015), Qiao R (2016), Qiao R (2016), Boldt K (2016)	18
BUB1B	0	CDC16	2	affinity chromatography technology, affinity chromatography technology	Chan GK (1999), Tipton AR (2013)	2
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
PPP1CC	2	VCP	6	affinity chromatography technology, affinity chromatography technology	Cid C (2007), Cid C (2007)	2
FZR1	1	NEK2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sedgwick GG (2012), Boekhout M (2015), Lee SB (2015)	3
NEK2	2	TCF25	0	two hybrid	Vinayagam A (2011)	1
PPP1CC	2	NEK2	2	two hybrid, two hybrid, far western blotting	Esteves SL (2012), Fardilha M (2011), Ferreira-Fernandes E (2015)	3
CDC27	2	ANAPC15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uzunova K (2012), Uzunova K (2012), Hein MY (2015)	3
ANAPC15	0	FZR1	1	affinity chromatography technology	Hein MY (2015)	1
NDC80	4	NEK2	2	pull down, enzymatic study, two hybrid, two hybrid	Chen Y (2002), Chen Y (2002), Chen Y (1997), Vinayagam A (2011)	4
CHEK1	2	FZR1	1	genetic interference	Srivas R (2016)	1
ANAPC15	0	CFAP97	2	affinity chromatography technology	Hein MY (2015)	1
FZR1	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lee SB (2015), Lee SB (2015)	2
CDC20	1	BUB1B	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Fang G (2002), Fang G (2002), Wu H (2000), Wu H (2000), Wu H (2000), Kallio MJ (2002), Sudakin V (2001), Sudakin V (2001), Skoufias DA (2001), Nilsson J (2008), Ho CY (2010), Ho CY (2010), Garnett MJ (2009), Hutchins JR (2010), Di Fiore B (2010), Di Fiore B (2010), Mansfeld J (2011), Jia L (2011), Braunstein I (2007), Eytan E (2008), Eytan E (2008), Ma HT (2011), Miniowitz-Shemtov S (2012), Tang Z (2001), Tang Z (2001), Tang Z (2001), Tang Z (2001), Bolanos-Garcia VM (2011), Ge S (2009), Liu L (2007), Westhorpe FG (2011), Westhorpe FG (2011), Kwan PS (2013), Tian W (2012), Tian W (2012), Tian W (2012), Santaguida S (2011), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Han JS (2014), Izawa D (2014), Hein JB (2014), So J (2015), Scialpi F (2015), Scialpi F (2015), Diaz-Martinez LA (2015), Diaz-Martinez LA (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Voets E (2015), Chen TC (2014), Lischetti T (2014), Lischetti T (2014), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Huttlin EL (2017), Izawa D (2012), Jia L (2016), Jia L (2016), Hein JB (2016), Kaisari S (2017)	73
CDC20	1	CDC16	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kallio MJ (2002), Kallio M (1998), Nilsson J (2008), Hutchins JR (2010), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Listovsky T (2013), Qiao R (2016), Izawa D (2012)	12
CDC27	2	CFAP97	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CDC27	2	CTNNB1	30	pull down	Gomes NP (2006)	1
PPP1CA	3	NEK2	2	two hybrid	Esteves SL (2012)	1
ODF2	1	NEK2	2	bioid	Gupta GD (2015)	1
NEK2	2	NEK2	2	biochemical, two hybrid, pull down, affinity chromatography technology	Fry AM (1999), Fry AM (1999), Fry AM (1999), Sedgwick GG (2013)	4
MYC	2	PPP1CA	3	affinity chromatography technology	Koch HB (2007)	1
IMMT	0	PDE4DIP	10	two hybrid	Vinayagam A (2011)	1
CDC20	1	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mansfeld J (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Wolthuis R (2008), Sedgwick GG (2012), Zhang Z (2012), Chang L (2014), Fogeron ML (2013), Hein JB (2014), Hein JB (2014), Voets E (2015), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Izawa D (2012), Izawa D (2012), Izawa D (2012), Izawa D (2012), Salsi V (2016)	25
CFAP97	2	NEK2	2	affinity chromatography technology	Hein MY (2015)	1
CDC16	2	CDC23	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
NEK2	2	GIT1	10	two hybrid	Vinayagam A (2011)	1
FZR1	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ANAPC4	0	NEK2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sedgwick GG (2013), Sedgwick GG (2013), Voets E (2015), Boekhout M (2015), Boekhout M (2015)	5
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
CLEC4C	0	NEK2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Chen Y (2002), Chen Y (2002), Chen Y (2002)	3
BUB1B	0	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chan GK (1999), Hutchins JR (2010), Lara-Gonzalez P (2011), Mansfeld J (2011), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Eytan E (2013), Wang K (2014), Han JS (2014), Han JS (2014), Lara-Gonzalez P (2011), So J (2015), Boekhout M (2015), Kelly A (2014), Craney A (2016), Qiao R (2016)	17
C16orf87	0	FZR1	1	affinity chromatography technology	Huttlin EL (2017)	1
C16orf87	0	NEK2	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC20	1	NEK2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sedgwick GG (2012), Boekhout M (2015), Boekhout M (2015), Kelly A (2014)	4
CDC23	3	BUB1B	0	affinity chromatography technology	Hein MY (2015)	1
SMURF1	4	DCTN1	6	affinity chromatography technology	Xie Y (2013)	1
MAPK1	1	NEK2	2	two hybrid, affinity chromatography technology, pull down	Lou Y (2004), Lou Y (2004), Lou Y (2004)	3
ANAPC4	0	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Ma HT (2011), Sedgwick GG (2012), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Sedgwick GG (2016), Izawa D (2012), Salsi V (2016)	9
NEK2	2	IMMT	0	two hybrid	Vinayagam A (2011)	1
C16orf87	0	CDC23	3	affinity chromatography technology	Huttlin EL (2017)	1
BUB1B	0	MAD2L1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sudakin V (2001), Sudakin V (2001), Ho CY (2010), Bolanos-Garcia VM (2011), Tipton AR (2011), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Han JS (2013), Wang K (2014), Wang K (2014), So J (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Lischetti T (2014), Tipton AR (2013), Tipton AR (2013), Boekhout M (2015), Sedgwick GG (2016), Sedgwick GG (2016), Sedgwick GG (2016)	23
CHEK1	2	NEK2	2	biochemical	Kraemer A (2004)	1
ANAPC15	0	CDC20	1	affinity chromatography technology, affinity chromatography technology	Uzunova K (2012), Hein MY (2015)	2
NEK2	2	EDRF1	6	two hybrid	Vinayagam A (2011)	1
ANAPC15	0	CDC16	2	affinity chromatography technology, affinity chromatography technology	Uzunova K (2012), Hein MY (2015)	2
CTNNB1	30	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
ANAPC4	0	CDC16	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Ma HT (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Masuda K (2015), Boekhout M (2015), Huttlin EL (2017)	14
NEK2	2	CSN2	0	enzymatic study	Toji S (2004)	1
SMURF1	4	ODF2	1	enzymatic study	Andrews PS (2010)	1
ANAPC15	0	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uzunova K (2012), Hein MY (2015), Hein MY (2015)	3
PRKN	1	TPM3	0	affinity chromatography technology	Zanon A (2013)	1
NEK2	2	DTD1	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	CHEK1	2	biochemical	Wan C (2015)	1
ANAPC15	0	NEK2	2	affinity chromatography technology	Hein MY (2015)	1
NEK2	2	SPTBN4	10	two hybrid	Vinayagam A (2011)	1
MCC	3	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
CDC20	1	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016)	8
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
NEK2	2	MAD2L1	0	affinity chromatography technology	Boekhout M (2015)	1
CFAP97	2	CDC16	2	affinity chromatography technology	Hein MY (2015)	1
ANAPC4	0	FZR1	1	biochemical, biochemical, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Boekhout M (2015), Huttlin EL (2017)	6
PRKN	1	NEK2	2	affinity chromatography technology, enzymatic study	Lee SB (2015), Lee SB (2015)	2
VCP	6	NEK2	2	affinity chromatography technology	Yu CC (2013)	1
MYC	2	MAPK1	1	pull down, pull down	Jin Z (2004), Gupta S (1994)	2
FANCA	5	NEK2	2	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim S (2013), Kim S (2013), Kim S (2013), Kim S (2013)	4
CFAP97	2	ANAPC4	0	affinity chromatography technology	Hein MY (2015)	1
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
MAD2L1	0	CDC16	2	affinity chromatography technology	Li Y (1997)	1
SMURF1	4	VCP	6	affinity chromatography technology	Xie Y (2013)	1
CDC27	2	CDC16	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Ollendorff V (1997), Kallio M (1998), Gmachl M (2000), Kraft C (2003), Li Y (1997), Lara-Gonzalez P (2011), Binne UK (2007), van Zon W (2010), Dube P (2005), Holzmann J (2011), Hayes MJ (2006), Tugendreich S (1995), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015), Hein MY (2015), Kelly A (2014), Listovsky T (2013), Qiao R (2016), Huttlin EL (2017), Boldt K (2016)	22
ANAPC4	0	CDC23	3	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015)	8
NEK2	2	IFT140	4	two hybrid	Vinayagam A (2011)	1
CDC27	2	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Mansfeld J (2011), Lara-Gonzalez P (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Ma HT (2011), Ma HT (2011), Dube P (2005), Holzmann J (2011), Wolthuis R (2008), Havugimana PC (2012), Uzunova K (2012), Song MS (2011), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Tran K (2010), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Voets E (2015), Masuda K (2015), Boekhout M (2015), Craney A (2016), Qiao R (2016), Izawa D (2012), Hein JB (2016)	34
NEK2	2	PDE4DIP	10	two hybrid	Vinayagam A (2011)	1
VCP	6	MAPK1	1	affinity chromatography technology	Yu CC (2013)	1
CDC27	2	NEK2	2	affinity chromatography technology, affinity chromatography technology	Hayes MJ (2006), Boekhout M (2015)	2
NEK2	2	CHGA	4	two hybrid	Vinayagam A (2011)	1
PRKN	1	CHGA	4	affinity chromatography technology	Zanon A (2013)	1
MYC	2	NEK2	2	genetic interference	Toyoshima M (2012)	1
CDC16	2	NEK2	2	affinity chromatography technology	Hein MY (2015)	1
C16orf87	0	CDC16	2	affinity chromatography technology	Huttlin EL (2017)	1
DCTN1	6	CFAP97	2	bioid	Gupta GD (2015)	1
ANAPC4	0	ANAPC15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Uzunova K (2012), Sedgwick GG (2012), Zhang Z (2012), Chang L (2014), Chang L (2015), Yamaguchi M (2015), Hein MY (2015)	8
CDC20	1	MAD2L1	0	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, unspecified method, pull down, affinity chromatography technology	Zhang Y (2001), Sihn CR (2003), Luo X (2000), Sironi L (2001), DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kallio M (1998), Fang G (1998), Fang G (1998), Skoufias DA (2001), Nilsson J (2008), Privette LM (2008), Stegmeier F (2007), Ho CY (2010), Ho CY (2010), Mansfeld J (2011), Gao YF (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Townsend K (2009), Lee YJ (2008), DAngiolella V (2003), Tang Z (2001), Tang Z (2001), Sironi L (2001), Sironi L (2001), Ge S (2009), Mapelli M (2007), Tipton AR (2011), Mondal G (2006), Mondal G (2006), Westhorpe FG (2011), De Antoni A (2005), De Antoni A (2005), Kwan PS (2013), Katayama H (2012), Fava LL (2011), Santaguida S (2011), Mapelli M (2006), Eytan E (2013), Eytan E (2013), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Eytan E (2014), Hein JB (2014), Yen AH (2010), Yen AH (2010), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Sedgwick GG (2016), Sedgwick GG (2016), Izawa D (2012), Izawa D (2012), Jia L (2016), Jia L (2016), Kaisari S (2017), Yang M (2008), Kim S (2010), Kim S (2010)	70
VCP	6	CDC27	2	affinity chromatography technology	Yu CC (2013)	1
NEK2	2	CTNNB1	30	enzymatic study, pull down, affinity chromatography technology	Mbom BC (2014), Mbom BC (2014), Mbom BC (2014)	3
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
NEK2	2	MCC	3	two hybrid	Vinayagam A (2011)	1
CFAP97	2	CDC23	3	affinity chromatography technology	Hein MY (2015)	1
FZR1	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kannan M (2012), Kannan M (2012), Wan L (2011), Wan L (2011), Wan L (2011), Wan L (2011)	6
PRKN	1	CDC20	1	affinity chromatography technology, affinity chromatography technology	Lee SB (2015), Lee SB (2015)	2
PPP1R2	2	NEK2	2	pull down	Eto M (2002)	1
VCP	6	EIF4A2	4	affinity chromatography technology	Yu CC (2013)	1
BUB1B	0	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Mansfeld J (2011), Izawa D (2011), Sedgwick GG (2012), Hein JB (2014), Di Fiore B (2015), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Boekhout M (2015), Sedgwick GG (2016), Izawa D (2012), Salsi V (2016)	13
C16orf87	0	CDC27	2	affinity chromatography technology	Huttlin EL (2017)	1
FZR1	1	CDC23	3	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
FZR1	1	CDC16	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
NEK2	2	DCTN1	6	two hybrid	Vinayagam A (2011)	1
MAPK1	1	PPP1CC	2	affinity chromatography technology	Quevedo C (2003)	1
NEK2	2	TPM3	0	two hybrid	Vinayagam A (2011)	1
EIF4A2	4	TPM3	0	affinity chromatography technology	Ewing RM (2007)	1
CDC23	3	EDRF1	6	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	MAPK1	1	affinity chromatography technology	Um JW (2012)	1
NEK2	2	CCDC85A	1	two hybrid	Vinayagam A (2011)	1
PPP1CA	3	DCTN1	6	two hybrid	Esteves SL (2012)	1
PPP1CC	2	NDC80	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC23	3	NEK2	2	affinity chromatography technology	Hein MY (2015)	1
FANCA	5	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dao KH (2012), Dao KH (2012), Huard CC (2014), Huard CC (2014)	4
FZR1	1	BUB1B	0	enzymatic study, pull down	Tian W (2012), Diaz-Martinez LA (2015)	2
C16orf87	0	ANAPC4	0	affinity chromatography technology	Huttlin EL (2017)	1
BFSP2	1	NEK2	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC27	2	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wassmann K (1998), Kallio M (1998), Li Y (1997), Li Y (1997), Lara-Gonzalez P (2011), Mansfeld J (2011), Visconti R (2010), Ma HT (2011), Sironi L (2001), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Lara-Gonzalez P (2011), Yen AH (2010), Hein MY (2015), Craney A (2016), Sedgwick GG (2016)	18
NEK2	2	DPP9	4	affinity chromatography technology	Huttlin EL (2017)	1
MCC	3	TPM3	0	affinity chromatography technology	Ewing RM (2007)	1