PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CREBZF	0	NFE2L1	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
CAPN1	3	NFE2L1	4	two hybrid	Jiang LQ (2002)	1
BACH2	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
GSK3B	1	NFE2L1	4	affinity chromatography technology, enzymatic study	Biswas M (2013), Biswas M (2013)	2
GSK3B	1	JUN	0	enzymatic study, imaging technique	Chen BK (2007), Chen TC (2014)	2
USP15	4	NFE2L1	4	affinity chromatography technology	Fukagai K (2016)	1
MAFF	0	NFE2L1	4	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Johnsen O (1996), Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	5
CD6	0	NFE2L1	4	two hybrid	Wang J (2011)	1
BTRC	1	NFE2L1	4	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
GATAD1	0	NFE2L1	4	affinity chromatography technology	Varier RA (2016)	1
FBXW11	2	KEAP1	0	affinity chromatography technology	Kim TY (2014)	1
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
PHF12	6	NFE2L1	4	affinity chromatography technology	Varier RA (2016)	1
NFE2L1	4	C8orf33	3	affinity chromatography technology	Hein MY (2015)	1
NFE2L1	4	RUSC2	6	affinity chromatography technology	Hein MY (2015)	1
BTRC	1	KEAP1	0	affinity chromatography technology, bioid	Sowa ME (2009), Coyaud E (2015)	2
NFE2L3	6	GSK3B	1	affinity chromatography technology, enzymatic study	Kannan MB (2015), Kannan MB (2015)	2
NFE2L3	6	NFE2L1	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
JUN	0	FBXW7	2	two hybrid, pull down, enzymatic study, unspecified method, affinity chromatography technology	Nateri AS (2004), Nateri AS (2004), Nateri AS (2004), Nateri AS (2004), Takada M (2017)	5
CREBZF	0	HCFC1	4	pull down, pull down	Lu R (2000), Misra V (2005)	2
JUN	0	NFE2L1	4	affinity chromatography technology, pull down	Venugopal R (1998), Venugopal R (1998)	2
NFE2L3	6	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2L3	6	HCFC1	4	affinity chromatography technology	Huttlin EL (2017)	1
NFE2L3	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
BACH2	6	MAFG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
FBXW11	2	GSK3B	1	two hybrid	Wallach T (2013)	1
NFE2L1	4	NFE2L1	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
USP15	4	KEAP1	0	enzymatic study	Villeneuve NF (2013)	1
KEAP1	0	NFE2L1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yu M (2011), Wang W (2006), Wang W (2006), Wang J (2011), Niture SK (2013)	5
MAFG	1	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
HCFC1	4	NFE2L1	4	two hybrid	Ravasi T (2010)	1
USP15	4	BTRC	1	affinity chromatography technology	Greenblatt MB (2016)	1
NFE2L1	4	WDFY3	17	affinity chromatography technology	Hein MY (2015)	1
NFE2L3	6	MAFG	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
NFE2L1	4	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
FBXW11	2	NFE2L1	4	affinity chromatography technology	Low TY (2014)	1
GSK3B	1	BTRC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Kitagawa M (1999), Gao C (2014), Gao C (2014), Gao C (2014)	4
NFE2L1	4	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Biswas M (2011), Biswas M (2013)	2
GATAD1	0	PHF12	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hein MY (2015), Varier RA (2016), Varier RA (2016)	5
NFE2L3	6	FBXW7	2	affinity chromatography technology	Kannan MB (2015)	1
MAFG	1	NFE2L1	4	pull down, fluorescent resonance energy transfe	Johnsen O (1996), Reinke AW (2013)	2
FBXW11	2	HCFC1	4	affinity chromatography technology	Kim TY (2014)	1
BTRC	1	HCFC1	4	affinity chromatography technology	Coyaud E (2015)	1
NFE2L1	4	BRD9	2	affinity chromatography technology	Hein MY (2015)	1