PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
JUN	0	SMAD4	9	affinity chromatography technology	Li X (2015)	1
FOXA1	2	NFIX	8	affinity chromatography technology	Li X (2015)	1
NFIX	8	HDAC1	4	affinity chromatography technology	Singh J (2002)	1
RFX1	3	NFIX	8	affinity chromatography technology	Norquay LD (2003)	1
FOXC1	0	CREB1	1	affinity chromatography technology	Li X (2015)	1
SKI	3	RB1	2	affinity chromatography technology	Tokitou F (1999)	1
RFX1	3	NFIB	2	affinity chromatography technology	Norquay LD (2003)	1
SMAD4	9	SKI	3	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Wu JW (2002), Stroschein SL (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Takeda M (2004), Takeda M (2004), Ferrand N (2010), Wu K (2003), Wu K (2003), Barrios-Rodiles M (2005), Colland F (2004), He J (2003), He J (2003), Jinnin M (2007), Li X (2015), Rashidian J (2015), Rashidian J (2015), Zhou F (2017)	21
SMAD4	9	NFIX	8	affinity chromatography technology	Li X (2015)	1
NFIX	8	RB1	2	affinity chromatography technology	Singh J (2002)	1
TRIM25	5	SKI	3	affinity chromatography technology	Choudhury NR (2017)	1
ISG15	0	HNRNPL	3	affinity chromatography technology	Zhao C (2005)	1
SMAD4	9	RFX1	3	two hybrid	Colland F (2004)	1
RB1	2	HDAC1	4	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fuks F (2000), Puri PL (2001), Puri PL (2001), Wang S (2002), Luo RX (1998), Luo RX (1998), Lai A (1999), Lai A (1999), Ferreira R (1998), Kimura H (2003), Qiu Z (2008), Fedele M (2006), Brown VD (2002), Khan MM (2001), Dasgupta P (2004), Chang YC (2001), Dahiya A (2000), Zhang HS (2000), Tokitou F (1999), Nguyen DX (2004), Takaki T (2004), Magnaghi-Jaulin L (1998), Magnaghi-Jaulin L (1998), Brehm A (1998), Brehm A (1998), Brehm A (1998), Sun JM (2007), Fan LX (2012), Harbour JW (1999), Brehm A (1999), Joshi P (2013), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	36
NFIX	8	NFIX	8	two hybrid	Rolland T (2014)	1
HNRNPL	3	SKI	3	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
JUN	0	SKI	3	affinity chromatography technology	Pessah M (2002)	1
FOS	0	NFIX	8	affinity chromatography technology	Li X (2015)	1
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
ISG15	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Zou W (2007), Zou W (2007)	2
FOXC1	0	NFIX	8	affinity chromatography technology	Li X (2015)	1
NFIX	8	JMJD6	1	two hybrid	Weimann M (2013)	1
TRIM25	5	NFIX	8	affinity chromatography technology	Choudhury NR (2017)	1
JUN	0	NFIX	8	affinity chromatography technology	Li X (2015)	1
SKI	3	NFIX	8	pull down, genetic interference	Tarapore P (1997), Tarapore P (1997)	2
CREB1	1	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Canettieri G (2003), Canettieri G (2003), Kim HC (2010)	4
NFIX	8	QRICH1	8	two hybrid	Rolland T (2014)	1
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
NFIX	8	PIR	0	two hybrid	Wendler WM (1997)	1
JUN	0	RB1	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down	Nishitani J (1999), Nishitani J (1999), Nishitani J (1999), Nead MA (1998), Nead MA (1998)	5
NFIB	2	NFIX	8	pull down, affinity chromatography technology	Liu Y (1997), Huttlin EL (2017)	2
FOXN1	3	NFIX	8	affinity chromatography technology	Li X (2015)	1
ISG15	0	NFIX	8	affinity chromatography technology	Zhao C (2005)	1
CREB1	1	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benbrook DM (1990), Li X (2015), Li X (2015)	3
HNRNPL	3	NFIX	8	affinity chromatography technology	Fei T (2017)	1
RFX1	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Y (2006), Wang KR (2007), Boldt K (2016)	3
TRIM25	5	SMAD4	9	affinity chromatography technology	Choudhury NR (2017)	1
FOXA1	2	CREB1	1	affinity chromatography technology	Li X (2015)	1
RBPJ	1	NFIX	8	affinity chromatography technology	Li X (2015)	1
NFIX	8	ZNF614	2	two hybrid	Rolland T (2014)	1
ISG15	0	SMAD4	9	affinity chromatography technology	Zhao C (2005)	1
CREB1	1	NFIX	8	affinity chromatography technology	Li X (2015)	1
HNRNPL	3	NFIB	2	affinity chromatography technology	Fei T (2017)	1
FOS	0	RB1	2	pull down	Nead MA (1998)	1