PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SFPQ	2	U2AF2	7	affinity chromatography technology, biochemical, affinity chromatography technology	Liu L (2011), Havugimana PC (2012), Whisenant TC (2015)	3
SFPQ	2	PSPC1	2	affinity chromatography technology	Huttlin EL (2017)	1
ERG	1	NONO	3	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
UBE2A	0	SFPQ	2	affinity chromatography technology	An H (2017)	1
LMNA	2	SFPQ	2	affinity chromatography technology	Depreux FF (2015)	1
LMNA	2	NONO	3	biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Roux KJ (2012), Depreux FF (2015)	3
FBXW7	2	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Thompson BJ (2007), Welcker M (2004), Welcker M (2004), Yada M (2004), Yada M (2004), Yada M (2004), Koch HB (2007), Kim BY (2010), Cho HJ (2010), Popov N (2007), Fujii M (2006), Yumimoto K (2012), Diefenbacher ME (2015), Kourtis N (2015), Kourtis N (2015), Li J (2017), Wang Y (2017), Reiterer V (2017), Chandra S (2013), Chandra S (2013), Chandra S (2013), Chandra S (2013)	22
ERG	1	HNRNPA1	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
HDAC1	4	SMARCD1	5	biochemical	Havugimana PC (2012)	1
SMARCA4	19	CTNNB1	30	affinity chromatography technology, two hybrid	Barker N (2001), Barker N (2001)	2
MYC	2	MYCN	2	affinity chromatography technology	Li X (2015)	1
PARK7	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Opsahl JA (2010), Opsahl JA (2010), Opsahl JA (2010)	3
AR	3	NONO	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ishitani K (2003), Ishitani K (2003), Ishitani K (2003), Dong X (2007)	4
HDAC1	4	SPI1	1	affinity chromatography technology, pull down, affinity chromatography technology	Suzuki M (2003), Suzuki M (2006), Kihara-Negishi F (2001)	3
H2AFX	1	NONO	3	affinity chromatography technology, affinity chromatography technology	Yang X (2010), Yang X (2010)	2
HNRNPA1	1	FUS	0	affinity chromatography technology	Roy R (2014)	1
U2AF2	7	HNRNPA1	1	affinity chromatography technology	Whisenant TC (2015)	1
MYC	2	PIN1	0	affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Yeh E (2004)	2
MYC	2	PPP1CA	3	affinity chromatography technology	Koch HB (2007)	1
RNF43	5	NONO	3	affinity chromatography technology, affinity chromatography technology	Miyamoto K (2008), Miyamoto K (2008)	2
NONO	3	U2AF2	7	affinity chromatography technology, biochemical, affinity chromatography technology	Liu L (2011), Wan C (2015), Whisenant TC (2015)	3
SFPQ	2	NONO	3	two hybrid, affinity chromatography technology, pull down, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Peng R (2002), Peng R (2002), Peng R (2002), Ito T (2008), Dong X (2007), Havugimana PC (2012), Wang J (2011), Hall-Pogar T (2007), Wan C (2015), Huttlin EL (2017)	10
NONO	3	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Liu L (2011), Liu L (2011), Liu L (2011), Liu L (2011)	4
AR	3	PSPC1	2	affinity chromatography technology	Ishitani K (2003)	1
ERG	1	AR	3	affinity chromatography technology, affinity chromatography technology	Yu J (2010), Grasso CS (2012)	2
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
LMNA	2	CTNNB1	30	affinity chromatography technology	Choi J (2004)	1
SMARCD1	5	SFPQ	2	affinity chromatography technology	Ito T (2008)	1
FUS	0	NONO	3	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Wang T (2014), Wan C (2015)	3
UBE2A	0	U2AF2	7	affinity chromatography technology	An H (2017)	1
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
AR	3	SMARCD1	5	two hybrid, bioid	van de Wijngaart DJ (2009), Lempiaeinen JK (2017)	2
PIN1	0	SFPQ	2	pull down	Ingham RJ (2005)	1
AR	3	SMARCA4	19	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Wang Q (2004), van de Wijngaart DJ (2009), Dai Y (2008), Lempiaeinen JK (2017)	4
U2AF2	7	PSPC1	2	biochemical, affinity chromatography technology	Wan C (2015), Whisenant TC (2015)	2
PARK7	0	AR	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Tillman JE (2007), Tillman JE (2007), Tillman JE (2007)	3
SMARCD1	5	NONO	3	affinity chromatography technology, pull down	Ito T (2008), Ito T (2008)	2
UBE2A	0	NONO	3	affinity chromatography technology, affinity chromatography technology	An H (2017), An H (2017)	2
NONO	3	SPI1	1	pull down, pull down, affinity chromatography technology	Hallier M (1996), Hallier M (1996), Hallier M (1996)	3
PIN1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Min SH (2012), Kourtis N (2015)	2
HDAC1	4	PIN1	0	biochemical	Wan C (2015)	1
MYC	2	NONO	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Koch HB (2007), Agrawal P (2010), Cobbold LC (2008), Cobbold LC (2008)	4
AR	3	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Liu X (2016), Liu X (2016)	2
PSPC1	2	NONO	3	two hybrid, two hybrid, affinity chromatography technology	Stelzl U (2005), Rolland T (2014), Huttlin EL (2017)	3
CTNNB1	30	AR	3	pull down, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang F (2002), Yang F (2002), Masiello D (2004), Song LN (2004), Amir AL (2003), Amir AL (2003), Mulholland DJ (2003), Mulholland DJ (2003), Pawlowski JE (2002), Mulholland DJ (2003), Levy L (2004)	11
NONO	3	PIN1	0	two hybrid, pull down, two hybrid	Rual JF (2005), Ingham RJ (2005), Rolland T (2014)	3
LMNA	2	HNRNPA1	1	bioid, affinity chromatography technology	Roux KJ (2012), Roy R (2014)	2
MYC	2	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Ewing RM (2007), Park J (2002), Pal S (2003), Ivanov AA (2017)	4
CTNNB1	30	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology	Tian Q (2004), Sato S (2005)	2
HNRNPA1	1	SFPQ	2	affinity chromatography technology, affinity chromatography technology, biochemical	Close P (2012), Close P (2012), Wan C (2015)	3
CTNNB1	30	PIN1	0	pull down	Ryo A (2001)	1
CTNNB1	30	FUS	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Sato S (2005), Sato S (2005), Sato S (2005), Sato S (2005)	4
PIN1	0	UBE2A	0	biochemical	Havugimana PC (2012)	1
PARK7	0	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Xu J (2005), Xu J (2005)	2
HDAC1	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Guo C (2007), Chen CS (2005)	2
MYC	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
FUS	0	PSPC1	2	affinity chromatography technology	Wang T (2014)	1
HDAC1	4	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008), Liu T (2007), Liu T (2007), Liu T (2007), Koch HB (2007), Hwang IY (2012), Hein MY (2015)	8
HNRNPA1	1	NONO	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Close P (2012), Close P (2012), Roy R (2014)	3
H2AFX	1	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, pull down	Park JH (2006), Lee HS (2010), Lee HS (2010)	3
RNF43	5	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Miyamoto K (2008), Miyamoto K (2008)	2
SPI1	1	FUS	0	biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Hallier M (1998), Hallier M (1998), Hallier M (1998), Hallier M (1998)	4
PIN1	0	U2AF2	7	pull down	Ingham RJ (2005)	1
H2AFX	1	LMNA	2	affinity chromatography technology, affinity chromatography technology	Yang X (2010), Depreux FF (2015)	2
FUS	0	SFPQ	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Wang T (2014), Wang T (2014), Wang T (2014), Wan C (2015)	4
HDAC1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Qiu Z (2008), Battaglioli E (2002), Hang CT (2010), DiRenzo J (2000)	4
SMARCD1	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Pal S (2003), Ito T (2008), Tando T (2010), Mak AB (2010), Oh J (2008), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
SFPQ	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tyson-Capper AJ (2009), Dong L (2011), Liu L (2011), Zhong N (2006), Zhong N (2006)	5
NONO	3	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang C (2008), Xu J (2005), Xu J (2005)	3
FBXW7	2	MYCN	2	affinity chromatography technology, affinity chromatography technology	Otto T (2009), Otto T (2009)	2
SMARCA4	19	NONO	3	affinity chromatography technology, pull down, affinity chromatography technology	Ito T (2008), Ito T (2008), Tando T (2010)	3
LMNA	2	U2AF2	7	affinity chromatography technology	Depreux FF (2015)	1
MYCN	2	NONO	3	affinity chromatography technology, unspecified method	Cobbold LC (2008), Cobbold LC (2008)	2
ERG	1	SFPQ	2	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
NONO	3	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Alfano L (2017), Alfano L (2017)	2
HDAC1	4	NONO	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Dong X (2007), Liu L (2011), Zhang C (2008)	3
H2AFX	1	HNRNPA1	1	affinity chromatography technology	Yang X (2010)	1
LMNA	2	FUS	0	bioid, affinity chromatography technology, affinity chromatography technology	Roux KJ (2012), Wang T (2014), Depreux FF (2015)	3
HEY1	2	NONO	3	pull down, affinity chromatography technology	Lopez-Mateo I (2016), Lopez-Mateo I (2016)	2
CTNNB1	30	NONO	3	affinity chromatography technology, affinity chromatography technology	Sato S (2005), Sato S (2005)	2
U2AF2	7	PARK7	0	affinity chromatography technology	Whisenant TC (2015)	1
NONO	3	NONO	3	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Wang J (2011), Rolland T (2014), Wallach T (2013), Yu H (2011)	5
HEY1	2	HNRNPA1	1	affinity chromatography technology	Lopez-Mateo I (2016)	1
SFPQ	2	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Liu L (2011), Liu L (2011), Liu L (2011)	3
AR	3	SFPQ	2	affinity chromatography technology, pull down	Dong X (2007), Dong X (2007)	2