PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
A2M	8	FIS1	0	two hybrid	Soler-Lopez M (2011)	1
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ACTN2	2	ACTN4	4	biochemical	Havugimana PC (2012)	1
NOS3	7	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CALM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, unspecified method, x-ray crystallography	Jung SB (2010), Jung SB (2010), Fleming I (2001), Chen PF (2009), Chen PF (2009), Piazza M (2012)	6
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
NOSIP	2	NOS3	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Schleicher M (2005), Dedio J (2001), Dedio J (2001), Dedio J (2001), Dedio J (2001), Dedio J (2001)	6
CALM1	0	AKT1	1	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
HDAC3	5	NOS3	7	affinity chromatography technology	Jung SB (2010)	1
EXOC6	1	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
APOE	1	HTRA1	3	two hybrid	Soler-Lopez M (2011)	1
ACTN4	4	CAMK2A	6	two hybrid, two hybrid	Walikonis RS (2001), Walikonis RS (2001)	2
APOE	1	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
MAST1	9	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	TXNDC11	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
APP	1	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	PI4K2A	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CDC37	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APP	1	PI4K2A	2	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
CALM1	0	HSP90AA1	7	pull down	Ning YM (1995)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
AKT1	1	CAMK2A	6	affinity chromatography technology	Klein JB (2005)	1
HDAC3	5	AKT1	1	affinity chromatography technology	Zampetaki A (2010)	1
PAXIP1	1	TECR	0	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	APP	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	EFEMP1	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ACTN2	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
A2M	8	ACTB	8	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Basso AD (2002), Basso AD (2002), Kim H (2014), Sun L (2012)	4
NOS3	7	APP	1	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ACTB	8	CAV1	0	affinity chromatography technology, imaging technique	Ji Y (2007), Luo X (2017)	2
GUCY1B3	0	NOS3	7	pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Venema RC (2003)	3
SIRT1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Lin Z (2012), Hein MY (2015)	2
ELAVL1	0	ACTB	8	affinity chromatography technology	Abdelmohsen K (2009)	1
PSEN1	11	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	KANK2	4	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
APOE	1	NOS3	7	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ELAVL1	0	CALM1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	CAMK2A	6	affinity chromatography technology	Taipale M (2012)	1
EXOC6	1	IMMT	0	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	ST13	2	affinity chromatography technology, pull down, pull down	Gano JJ (2010), Graumann K (2000), Sun L (2012)	3
PSEN1	11	KANK2	4	two hybrid	Soler-Lopez M (2011)	1
MAGEA11	1	NOS3	7	two hybrid	Rolland T (2014)	1
APOE	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
GCDH	2	NOS3	7	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN2	3	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Brouet A (2001), Brouet A (2001), Dimmeler S (1999), Chen TC (2014)	4
MAST1	9	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	H3F3A	1	two hybrid	Soler-Lopez M (2011)	1
GOLGA2	2	KANK2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PI4K2A	2	HSP90AA1	7	affinity chromatography technology	Jung G (2011)	1
ELAVL1	0	ACTN4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
NOS3	7	ACTB	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ji Y (2007), Ji Y (2007), Ji Y (2007), Ji Y (2007)	4
NOS3	7	NOSTRIN	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Zimmermann K (2002), Zimmermann K (2002), Zimmermann K (2002), Zimmermann K (2002), Zimmermann K (2002), Zimmermann K (2002)	6
A2M	8	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
HSP90AA1	7	NOS3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Harris MB (2000), Harris MB (2000), Stepp DW (2002), Fontana J (2002), Fontana J (2002), Brouet A (2001), Brouet A (2001)	9
PSEN2	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CDC37	0	affinity chromatography technology, two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
NOS3	7	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	NOS3	7	two hybrid, affinity chromatography technology, biochemical, x-ray crystallography, x-ray crystallography, x-ray crystallography	Dedio J (2001), Cai S (2005), Cai S (2002), Fischmann TO (1999), Rosenfeld RJ (2002), Garcin ED (2008)	6
NOS3	7	MPRIP	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
GUCY1B3	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Venema RC (2003)	3
PSEN1	11	UMPS	4	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	UMPS	4	two hybrid	Soler-Lopez M (2011)	1
APOE	1	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
PAXIP1	1	UMPS	4	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CDC37	0	two hybrid	Soler-Lopez M (2011)	1
AKT1	1	ACTB	8	affinity chromatography technology	Zhu QS (2011)	1
A2M	8	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CAMK2A	6	affinity chromatography technology	Fleming I (2001)	1
NOS3	7	RNF31	3	two hybrid	Soler-Lopez M (2011)	1
CALM1	0	IMMT	0	pull down	Shen X (2005)	1
NOS3	7	ST13	2	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
AKT1	1	APP	1	pull down	Olah J (2011)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	EFEMP2	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	PAXIP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	SIRT1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CAV1	0	NOS3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Garcia-Cardena G (1996), Garcia-Cardena G (1996), Brouet A (2001), Ji Y (2007), Linton EA (2003), Linton EA (2003)	6
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	UMPS	4	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	FIS1	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
GUCY1B3	0	APP	1	pull down	Olah J (2011)	1
PSEN1	11	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN2	3	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APP	1	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
SIRT1	3	NOS3	7	affinity chromatography technology	Chen Z (2010)	1
NOS3	7	HTRA1	3	two hybrid	Soler-Lopez M (2011)	1
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
SIRT1	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sundaresan NR (2011), Sundaresan NR (2011), Sundaresan NR (2011)	3
NOS3	7	ACTN4	4	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	ST13	2	affinity chromatography technology	Abdelmohsen K (2009)	1
APP	1	CAV1	0	biochemical, unspecified method	Ikezu T (1998), Ikezu T (1998)	2
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
CDC37	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
RNF32	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
GOLGA2	2	NOS3	7	two hybrid	Rolland T (2014)	1
NOS3	7	IMMT	0	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
EXOSC1	0	APP	1	pull down	Olah J (2011)	1
NOS3	7	TECR	0	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1