PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MCM2	3	CNOT4	4	affinity chromatography technology	Drissi R (2015)	1
UBE2D3	1	CNOT4	4	two hybrid	van Wijk SJ (2009)	1
KDM5C	9	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
CNOT4	4	UBE2E1	1	two hybrid, two hybrid	Winkler GS (2004), Albert TK (2002)	2
EP300	36	UBE2D1	0	pull down, pull down	Shi D (2009), Grossman SR (2003)	2
UBE2E3	0	CNOT4	4	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Winkler GS (2004), Albert TK (2002)	3
ELAVL1	0	CNOT4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D2	0	CNOT4	4	two hybrid, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Dominguez C (2004), Winkler GS (2004), Winkler GS (2004), Albert TK (2002), Albert TK (2002), Albert TK (2002), Winkler GS (2004), Albert TK (2002), Zhang L (2015)	10
EP300	36	MCM2	3	pull down	Karmakar S (2010)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
RBM15	7	CNOT4	4	affinity chromatography technology, enzymatic study, unspecified method	Zhang L (2015), Zhang L (2015), Zhang L (2015)	3
CNOT4	4	CNOT4	4	enzymatic study, enzymatic study	Winkler GS (2004), Albert TK (2002)	2
CNOT4	4	KDM5C	9	enzymatic study	Mersman DP (2009)	1
MCM2	3	UBE2D2	0	affinity chromatography technology	Drissi R (2015)	1
UBE2W	0	CNOT4	4	two hybrid	van Wijk SJ (2009)	1
XPO1	8	CNOT1	10	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	UBE2N	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CNOT4	4	EP300	36	two hybrid	Wang J (2011)	1
XPO1	8	CNOT4	4	affinity chromatography technology	Kirli K (2015)	1
MCM2	3	UBE2D3	1	affinity chromatography technology	Drissi R (2015)	1
ELAVL1	0	UBE2W	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	UBE2D4	0	affinity chromatography technology	Drissi R (2015)	1
ELAVL1	0	RBM15	7	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D4	0	CNOT4	4	two hybrid	van Wijk SJ (2009)	1
CNOT4	4	UBE2D1	0	pull down	Mersman DP (2009)	1
MCM2	3	UBE2D1	0	affinity chromatography technology	Drissi R (2015)	1
UBE2N	1	CNOT4	4	two hybrid	van Wijk SJ (2009)	1
CNOT1	10	CNOT4	4	two hybrid, two hybrid	Albert TK (2000), Albert TK (2002)	2