PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RARA	5	ARNTL	2	pull down	McNamara P (2001)	1
NPAS2	0	CREBBP	29	pull down	Curtis AM (2004)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
CLOCK	0	RORC	4	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
CLOCK	0	CSNK2B	5	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
NPAS2	0	RASSF7	0	two hybrid	Corominas R (2014)	1
TRAF4	1	NPAS2	0	two hybrid	Rozan LM (2006)	1
EP300	36	CLOCK	0	pull down	Curtis AM (2004)	1
CRY2	2	DEC1	0	two hybrid	Wallach T (2013)	1
SHMT2	3	HGS	5	affinity chromatography technology	Castello A (2012)	1
ARNTL	2	RORC	4	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
EP300	36	CRX	0	two hybrid	Yanagi Y (2000)	1
EP300	36	RXRA	1	affinity chromatography technology, affinity chromatography technology	Zhao WX (2007), Zhao WX (2007)	2
CLOCK	0	DEC1	0	two hybrid	Wallach T (2013)	1
NPAS2	0	RHOXF1	0	two hybrid	Ravasi T (2010)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
DEC1	0	RORC	4	two hybrid	Wallach T (2013)	1
CLOCK	0	CRY1	0	two hybrid	Wallach T (2013)	1
RARA	5	NPAS2	0	two hybrid, pull down	McNamara P (2001), McNamara P (2001)	2
CLOCK	0	NPAS2	0	two hybrid	Wallach T (2013)	1
CRY1	0	HNRNPL	3	affinity chromatography technology	Papp SJ (2015)	1
CREBBP	29	CLOCK	0	affinity chromatography technology	Lee Y (2015)	1
ARNTL	2	ARNTL2	0	affinity chromatography technology	Huttlin EL (2017)	1
KAT2B	2	NCOA3	3	two hybrid, pull down	Korzus E (1998), Takeshita A (1997)	2
EP300	36	ARNTL	2	pull down	Curtis AM (2004)	1
EP300	36	RORC	4	affinity chromatography technology	Wu Q (2015)	1
CRY2	2	NPAS2	0	two hybrid	Wallach T (2013)	1
ARNTL	2	DEC1	0	two hybrid	Wallach T (2013)	1
CREBBP	29	ARNTL	2	affinity chromatography technology	Lee Y (2015)	1
CRY2	2	HSP90AA1	7	affinity chromatography technology	Papp SJ (2015)	1
HSP90AA1	7	NPAS2	0	pull down	Hogenesch JB (1997)	1
ARNTL2	0	RORC	4	two hybrid	Wallach T (2013)	1
SHMT2	3	NPAS2	0	affinity chromatography technology	Castello A (2012)	1
ARNTL	2	CSNK2B	5	two hybrid	Wallach T (2013)	1
NPAS2	0	KAT2B	2	pull down	Curtis AM (2004)	1
CRY1	0	DEC1	0	two hybrid	Wallach T (2013)	1
CREBBP	29	RARA	5	affinity chromatography technology, affinity chromatography technology	Reineke EL (2007), Tsai LN (2008)	2
KAT2B	2	CLOCK	0	pull down	Curtis AM (2004)	1
ARNTL	2	CRY2	2	two hybrid	Wallach T (2013)	1
RARA	5	NCOA3	3	pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Torchia J (1997), Reineke EL (2007), Reineke EL (2007), Albers M (2005), Takeshita A (1997), Ferry C (2009), Gianni M (2006), Li CW (2010)	8
NPAS2	0	EFS	2	two hybrid	Corominas R (2014)	1
CLOCK	0	CRY2	2	two hybrid	Wallach T (2013)	1
NCOA3	3	RXRA	1	pull down, pull down, imaging technique, pull down, pull down	Chen H (1997), Lee WY (2002), Sinkkonen L (2005), Yang W (2000), Takeshita A (1997)	5
RXRA	1	NPAS2	0	two hybrid, pull down	McNamara P (2001), McNamara P (2001)	2
CSNK2B	5	RXRA	1	two hybrid	Vinayagam A (2011)	1
NPAS2	0	ARNTL	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology	McNamara P (2001), McNamara P (2001), Hogenesch JB (1998), Hogenesch JB (1998), Hogenesch JB (1998), Corominas R (2014), Wallach T (2013), Huttlin EL (2017)	8
ARNT2	5	NPAS2	0	two hybrid	Corominas R (2014)	1
RXRA	1	ARNTL	2	pull down	McNamara P (2001)	1
ARNT2	5	TRAF4	1	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
CRY1	0	CSNK2B	5	two hybrid	Wallach T (2013)	1
DEC1	0	NPAS2	0	two hybrid	Wallach T (2013)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
RARA	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Subbaramaiah K (2002), Reineke EL (2007)	2
CLOCK	0	ARNTL	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Ooe N (2004), McNamara P (2001), McNamara P (2001), Hogenesch JB (1998), Hosoda H (2009), Alhopuro P (2010), Wallach T (2013), Wallach T (2013), Lee Y (2015), Huttlin EL (2017), Boldt K (2016)	11
NPAS2	0	HESX1	0	two hybrid	Ravasi T (2010)	1
NPAS2	0	ZSCAN1	2	two hybrid	Ravasi T (2010)	1
HNRNPL	3	NPAS2	0	affinity chromatography technology	Fei T (2017)	1
NPAS2	0	HGS	5	two hybrid	Corominas R (2014)	1
RXRA	1	CLOCK	0	two hybrid, pull down	McNamara P (2001), McNamara P (2001)	2
NPAS2	0	ARNTL2	0	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
KAT2B	2	ARNTL	2	pull down	Curtis AM (2004)	1
RARA	5	CLOCK	0	two hybrid, pull down, pull down	McNamara P (2001), McNamara P (2001), McNamara P (2001)	3
CSNK2B	5	DEC1	0	two hybrid	Wallach T (2013)	1
NPAS2	0	RORC	4	two hybrid	Wallach T (2013)	1
HNRNPL	3	RXRA	1	affinity chromatography technology	Fei T (2017)	1
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
CRY1	0	CRY2	2	affinity chromatography technology, affinity chromatography technology	Papp SJ (2015), Huttlin EL (2017)	2
NCOA3	3	CREBBP	29	two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Naltner A (2000), Wu RC (2002), Wu RC (2002), Kamei Y (1996), Naeem H (2007), Naeem H (2007), Torchia J (1997), Torchia J (1997), Torchia J (1997), Torchia J (1997), Takeshita A (1997), Wu RC (2004), Corkery D (2011), Yi P (2005), Ceschin DG (2011)	15
CLOCK	0	ARNTL2	0	two hybrid, affinity chromatography technology	Ooe N (2004), Huttlin EL (2017)	2
CRY1	0	NPAS2	0	two hybrid	Wallach T (2013)	1
ARNT2	5	NCOA3	3	two hybrid	Corominas R (2014)	1
HSP90AA1	7	ARNTL	2	pull down	Hogenesch JB (1997)	1
HNRNPL	3	CREBBP	29	affinity chromatography technology	Fei T (2017)	1
NCOA3	3	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, imaging technique, two hybrid, enzymatic study, affinity chromatography technology, pull down	Pao GM (2000), Feng Q (2006), Demarest SJ (2002), Demarest SJ (2002), Arimura A (2004), Font de Mora J (2000), Wang F (2010), Yi P (2005), Chen H (1999), Yi P (2015), Yi P (2015)	11
EP300	36	NPAS2	0	pull down, pull down	Curtis AM (2004), Curtis AM (2004)	2
ARNTL	2	CRY1	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Griffin EA (1999), Wallach T (2013), Wallach T (2013), Papp SJ (2015)	4
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
NPAS2	0	CRX	0	two hybrid	Corominas R (2014)	1
CSNK2B	5	NPAS2	0	two hybrid	Wallach T (2013)	1
NPAS2	0	RPL6	0	two hybrid	Wang J (2011)	1
RARA	5	KAT2B	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu X (2004), Korzus E (1998), Reineke EL (2007)	3
NPAS2	0	NCOA3	3	pull down	Curtis AM (2004)	1