Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ATP2B1	rs12817819	CT + TT	Antihypertensives	efficacy	yes	45,573 SNPs included in association analysis with resistant hypertension (RHTN) in European Americans and Hispanics from the INVEST cohort. Statistical threshold of p=2.6 x 10^-6 used. No SNP achieved this threshold, but the top signal from a meta-analysis of the European American and Hispanic INVEST cohorts was rs12817819. There was a 57% to 76% increase in risk for RHTN for each additional copy of the T allele. To replicate this association, it was tested in a different cohort (Women's Ischemia Syndrome Evaluation (WISE)); there was a consistent trend for this SNP and RHTN, though it did not achieve statistical significance. However, chip-wide significance was achieved in a meta-analysis of both INVEST cohorts and the WISE cohort. No evidence of heterogeneity was seen across the 3 studies. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes CT + TT are associated with increased resistance to Antihypertensives in people with Coronary Artery Disease or Hypertension as compared to genotype CC.	25385345	1446908047