PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NR4A2	6	RXRB	0	two hybrid	Albers M (2005)	1
COPS5	0	NCOA1	6	two hybrid, pull down	Chauchereau A (2000), Chauchereau A (2000)	2
SMARCA2	17	SIN3A	13	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sif S (2001), Sif S (2001), Pal S (2003), Pal S (2003), Nakamura T (2002), Nakamura T (2002), Kemper JK (2004), Kemper JK (2004), Wan C (2015)	9
NR4A2	6	RXRA	1	two hybrid, two hybrid, pull down	Albers M (2005), Perlmann T (1995), Perlmann T (1995)	3
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
NR4A2	6	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Sekiya T (2011), Sekiya T (2011)	2
BAZ1B	5	SMARCA4	19	biochemical	Havugimana PC (2012)	1
PPARG	0	COPS5	0	two hybrid	Albers M (2005)	1
CDKN2D	0	NR4A2	6	two hybrid	Rolland T (2014)	1
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
RUNX1	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Bakshi R (2010), Bakshi R (2010)	2
SFPQ	2	SIN3A	13	affinity chromatography technology, imaging technique, affinity chromatography technology	Tyson-Capper AJ (2009), Dong X (2007), Liu L (2011)	3
NR4A2	6	TCEAL5	0	pull down	Miyamoto-Sato E (2010)	1
NCOA1	6	PPARGC1A	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
NR4A2	6	SFPQ	2	affinity chromatography technology	Jacobs FM (2009)	1
RXRA	1	PPARGC1A	3	affinity chromatography technology, pull down, two hybrid, two hybrid	Delerive P (2002), Delerive P (2002), Delerive P (2002), Delerive P (2002)	4
ELAVL1	0	SFPQ	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NCOA1	6	NR4A2	6	affinity chromatography technology	Holla VR (2011)	1
PPARG	0	NCOR2	12	imaging technique, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, two hybrid, pull down, unspecified method	Guan HP (2005), Guan HP (2005), Albers M (2005), Lefebvre B (2010), Song K (2013), Lee G (2002), Carmona MC (2007), Tagami T (2009), Jeninga EH (2007), Koppen A (2009)	10
SFPQ	2	PPARGC1A	3	affinity chromatography technology, affinity chromatography technology	Zhong N (2008), Zhong N (2008)	2
PPARG	0	NR4A2	6	unspecified method	Lee G (2002)	1
NR4A2	6	COPS5	0	two hybrid	Albers M (2005)	1
PPARG	0	SMARCA4	19	affinity chromatography technology	Debril MB (2004)	1
NCOR2	12	RXRA	1	two hybrid, pull down, two hybrid, two hybrid	Tagami T (1998), Mouchon A (1999), Li H (1997), Albers M (2005)	4
RXRB	0	PPARG	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Albers M (2005), Nickkho-Amiry M (2012), Li X (2015)	3
NCOR2	12	SMARCA4	19	biochemical	Li J (2000)	1
NR4A2	6	SIN3A	13	affinity chromatography technology	Jacobs FM (2009)	1
PPARGC1A	3	NR4A2	6	affinity chromatography technology	Holla VR (2011)	1
SIN3A	13	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Imai Y (2004), Imai Y (2004)	2
COPS5	0	SMARCA4	19	affinity chromatography technology	Bennett EJ (2010)	1
PPARG	0	NCOA1	6	fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, unspecified method, pull down, two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, unspecified method	Iannone MA (2001), Yang W (2000), Feige JN (2007), DiRenzo J (1997), Needham M (2000), Heinlein CA (1999), Qin C (2004), Chan CM (2013), Chou WL (2007), Nolte RT (1998), Lee G (2002), Agostini M (2006), Waku T (2010), Waku T (2010), Carmona MC (2007), Molnar F (2005), Chintharlapalli S (2007), Jeninga EH (2007), Koppen A (2009)	19
ELAVL1	0	RUNX1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NR4A2	6	SMARCA2	17	affinity chromatography technology, pull down	Bilodeau S (2006), Bilodeau S (2006)	2
NCOR2	12	SIN3A	13	biochemical, pull down	Li J (2000), Huang EY (2000)	2
PPARG	0	PPARGC1A	3	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, unspecified method	Wallberg AE (2003), Wallberg AE (2003), Puigserver P (1999), Feige JN (2007), Kim K (2009), Qin C (2004), Narkar VA (2008), Agostini M (2006), Li Y (2008), Carmona MC (2007), Carmona MC (2007), Chintharlapalli S (2007), Wang LH (2007), Koppen A (2009), Koppen A (2009)	15
SMARCA4	19	SMARCA2	17	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Reyes JC (1997), Pal S (2003), Ito T (2008), Ito T (2008), Havugimana PC (2012)	5
SMARCA2	17	SFPQ	2	affinity chromatography technology	Ito T (2008)	1
RXRB	0	NCOA1	6	two hybrid	Albers M (2005)	1
RUNX1	0	NCOR2	12	x-ray crystallography	Liu Y (2007)	1
RXRA	1	SMARCA4	19	affinity chromatography technology	Huuskonen J (2005)	1
NR4A2	6	SMARCA4	19	affinity chromatography technology, pull down	Bilodeau S (2006), Bilodeau S (2006)	2
SMARCA4	19	NCOA1	6	genetic interference	DiRenzo J (2000)	1
NR4A2	6	NCOR2	12	affinity chromatography technology	Jacobs FM (2009)	1
ELAVL1	0	NR4A2	6	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	SFPQ	2	affinity chromatography technology	Bennett EJ (2010)	1
SMARCA4	19	SIN3A	13	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sif S (2001), Sif S (2001), Kuzmichev A (2002), Kuzmichev A (2002), Qiu Z (2008), Xu Z (2006), Pal S (2003), Pal S (2003)	8
NR4A2	6	BAZ1B	5	pull down	Miyamoto-Sato E (2010)	1
PPARG	0	SFPQ	2	pull down, affinity chromatography technology, two hybrid	Tsukahara T (2013), Tsukahara T (2013), Tsukahara T (2013)	3
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30