PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TCF12	14	TRIM72	5	two hybrid	Rolland T (2014)	1
TRIM72	5	UBE2H	3	pull down, affinity chromatography technology, affinity chromatography technology	Yi JS (2013), Yi JS (2013), Yi JS (2013)	3
PTK2	2	UBE2H	3	affinity chromatography technology, affinity chromatography technology	Nguyen N (2014), Nguyen N (2014)	2
TRIM72	5	CAVIN1	0	affinity chromatography technology, affinity chromatography technology	Zhu H (2011), Zhu H (2011)	2
PTK2	2	TRIM72	5	affinity chromatography technology, affinity chromatography technology	Nguyen N (2014), Nguyen N (2014)	2
UBE2I	0	TRIM72	5	two hybrid	Markson G (2009)	1
TRIM72	5	UBE2N	1	pull down	Yi JS (2013)	1
UBE2I	0	MYH9	19	enzymatic study	Matafora V (2009)	1
TRIM72	5	MYH9	19	affinity chromatography technology	Lin P (2012)	1
TRIM32	2	TRIM72	5	enzymatic study	Mokhonova EI (2015)	1
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8