Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
OPRK1 4986 CEBRANOPADOL CHEMBL2364605 agonist GuideToPharmacologyInteractions, ChemblInteractions
OPRK1 4986 ETORPHINE (CHEMBL1908334) CHEMBL1908334 agonist GuideToPharmacologyInteractions, DrugBank 7739347, 17720886, 16433932
OPRK1 4986 CARFENTANIL CHEMBL290429 agonist DrugBank 1656846, 15853689
OPRK1 4986 DIHYDROMORPHINE CHEMBL1500 agonist GuideToPharmacologyInteractions, DrugBank 19474215, 16777416, 15178355
OPRK1 4986 ASIMADOLINE CHEMBL1190199 agonist TdgClinicalTrial, DrugBank, TTD
OPRK1 4986 METHYLNALTREXONE CHEMBL1186579 antagonist GuideToPharmacologyInteractions, DrugBank 17504835
OPRK1 4986 HYDROCODONE CHEMBL1457 agonist GuideToPharmacologyInteractions, TEND
OPRK1 4986 NALBUPHINE CHEMBL895 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
OPRK1 4986 TIFLUADOM CHEMBL169703 agonist GuideToPharmacologyInteractions
OPRK1 4986 DAMGO CHEMBL38874 agonist GuideToPharmacologyInteractions
OPRK1 4986 FENTANYL CHEMBL596 agonist GuideToPharmacologyInteractions
OPRK1 4986 ESMOLOL CHEMBL768 antagonist GuideToPharmacologyInteractions
OPRK1 4986 NALOXONE CHEMBL80 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions
OPRK1 4986 ODELEPRAN CHEMBL2103878 antagonist ChemblInteractions
OPRK1 4986 OXYMORPHONE HYDROCHLORIDE CHEMBL1200794 agonist ChemblInteractions
OPRK1 4986 CODEINE PHOSPHATE HYDRATE CHEMBL1201099 agonist ChemblInteractions
OPRK1 4986 SAMIDORPHAN CHEMBL426084 TdgClinicalTrial
OPRK1 4986 HYDROCODONE POLISTIREX CHEMBL1201470 agonist ChemblInteractions
OPRK1 4986 SUFENTANIL CHEMBL658 TdgClinicalTrial
OPRK1 4986 PENTAZOCINE CHEMBL560 TdgClinicalTrial, TEND
OPRK1 4986 PROGESTERONE CHEMBL103 activator DrugBank 8867260
OPRK1 4986 MENTHOL CHEMBL256087 agonist DrugBank 7851817, 11897159
OPRK1 4986 DEZOCINE CHEMBL1685 antagonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 11752352, 17139284, 17016423, 16433932
OPRK1 4986 DIACETYLMORPHINE CHEMBL459324 agonist DrugBank 20352414, 18343363
OPRK1 4986 ALVIMOPAN CHEMBL270190 antagonist GuideToPharmacologyInteractions, DrugBank 15882122, 17340127
OPRK1 4986 ELUXADOLINE CHEMBL2159122 agonist DrugBank
OPRK1 4986 CHEMBL561339 CHEMBL561339 agonist GuideToPharmacologyInteractions
OPRK1 4986 CHEMBL25230 CHEMBL25230 agonist GuideToPharmacologyInteractions
OPRK1 4986 HYDROMORPHONE CHEMBL398707 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
OPRK1 4986 ENCAINIDE CHEMBL315838 agonist GuideToPharmacologyInteractions
OPRK1 4986 ENADOLINE CHEMBL318859 agonist GuideToPharmacologyInteractions
OPRK1 4986 NALFURAFINE CHEMBL267495 agonist GuideToPharmacologyInteractions
OPRK1 4986 NORMORPHINE CHEMBL1227 agonist GuideToPharmacologyInteractions
OPRK1 4986 DYNORPHIN B CHEMBL500830 agonist GuideToPharmacologyInteractions
OPRK1 4986 METHADONE CHEMBL651 agonist GuideToPharmacologyInteractions
OPRK1 4986 NORBINALTORPHIMINE CHEMBL573214 antagonist GuideToPharmacologyInteractions
OPRK1 4986 CHEMBL2311186 CHEMBL2311186 antagonist GuideToPharmacologyInteractions
OPRK1 4986 ANILERIDINE PHOSPHATE CHEMBL1200543 agonist ChemblInteractions
OPRK1 4986 LEVALLORPHAN TARTRATE CHEMBL2062276 partial agonist ChemblInteractions
OPRK1 4986 MEPERIDINE CHEMBL607 TdgClinicalTrial, TEND
OPRK1 4986 COCAINE CHEMBL370805 TdgClinicalTrial, TEND
OPRK1 4986 BENZHYDROCODONE HYDROCHLORIDE CHEMBL3137310 TdgClinicalTrial
OPRK1 4986 NALBUPHINE HYDROCHLORIDE CHEMBL1201132 agonist ChemblInteractions
OPRK1 4986 AXOMADOL CHEMBL2107731 agonist ChemblInteractions
OPRK1 4986 MORPHINE CHEMBL70 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 7959748, 17139284, 17016423, 9808678, 16753266
OPRK1 4986 MIRTAZAPINE CHEMBL654 agonist DrugBank 12372565
OPRK1 4986 DIPRENORPHINE CHEMBL281786 antagonist GuideToPharmacologyInteractions, DrugBank 20641600
OPRK1 4986 Buprenorphine Hydrochloride CHEMBL2368861 agonist ChemblInteractions, DrugBank
OPRK1 4986 TRAMADOL CHEMBL1237044 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
OPRK1 4986 ETHYLKETOCYCLAZOCINE CHEMBL279968 agonist GuideToPharmacologyInteractions
OPRK1 4986 CORTICOTROPIN CHEMBL1201610 agonist GuideToPharmacologyInteractions
OPRK1 4986 CHEMBL1797687 CHEMBL1797687 agonist GuideToPharmacologyInteractions
OPRK1 4986 BUTORPHANOL CHEMBL33986 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
OPRK1 4986 EDROPHONIUM CHEMBL1104 agonist GuideToPharmacologyInteractions
OPRK1 4986 ETONITAZENE CHEMBL312040 agonist GuideToPharmacologyInteractions
OPRK1 4986 GUANIDINONALTRINDOLE CHEMBL485832 antagonist GuideToPharmacologyInteractions
OPRK1 4986 BUPRENORPHINE CHEMBL511142 agonist, antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
OPRK1 4986 NALTREXONE CHEMBL19019 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
OPRK1 4986 NALFURAFINE HYDROCHLORIDE CHEMBL490665 agonist ChemblInteractions
OPRK1 4986 NALTREXONE HYDROCHLORIDE CHEMBL1201149 antagonist ChemblInteractions
OPRK1 4986 BUTORPHANOL TARTRATE CHEMBL299400 partial agonist ChemblInteractions
OPRK1 4986 CHEMBL1255944 CHEMBL1255944 antagonist TTD
OPRK1 4986 CODEINE SULFATE CHEMBL284671 agonist ChemblInteractions
OPRK1 4986 PROPOXYPHENE HYDROCHLORIDE CHEMBL1237104 antagonist DrugBank 6151117, 11752352
OPRK1 4986 MIANSERIN CHEMBL6437 agonist DrugBank 22708686
OPRK1 4986 TAPENTADOL CHEMBL1201776 DrugBank 10592235
OPRK1 4986 KETOBEMIDONE CHEMBL47072 agonist DrugBank 8153059
OPRK1 4986 PROPOXYPHENE NAPSYLATE CHEMBL1237085 agonist DrugBank 6151117, 11752352
OPRK1 4986 CHEMBL442577 CHEMBL442577 agonist GuideToPharmacologyInteractions
OPRK1 4986 TECHNETIUM TC 99M TILMANOCEPT CHEMBL2108726 agonist GuideToPharmacologyInteractions
OPRK1 4986 DYNORPHIN A (1-17) CHEMBL411557 agonist GuideToPharmacologyInteractions
OPRK1 4986 SALVINORIN A CHEMBL445332 agonist GuideToPharmacologyInteractions
OPRK1 4986 U-69593 CHEMBL440765 agonist GuideToPharmacologyInteractions
OPRK1 4986 NALORPHINE CHEMBL415284 agonist GuideToPharmacologyInteractions
OPRK1 4986 NALOXONE BENZOYLHYDRAZONE CHEMBL1256836 agonist GuideToPharmacologyInteractions
OPRK1 4986 REL-PENTAZOCINE CHEMBL397705 agonist GuideToPharmacologyInteractions
OPRK1 4986 BNTX CHEMBL252172 antagonist GuideToPharmacologyInteractions
OPRK1 4986 NALMEFENE CHEMBL982 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions
OPRK1 4986 NALTRIBEN CHEMBL100940 antagonist GuideToPharmacologyInteractions
OPRK1 4986 NALTRINDOLE CHEMBL567175 antagonist GuideToPharmacologyInteractions
OPRK1 4986 QUADAZOCINE CHEMBL2111022 antagonist GuideToPharmacologyInteractions
OPRK1 4986 ZYKLOPHIN CHEMBL2372399 antagonist GuideToPharmacologyInteractions
OPRK1 4986 OXYCODONE CHEMBL656 TdgClinicalTrial, TEND
OPRK1 4986 CODEINE POLISTIREX CHEMBL1201463 agonist ChemblInteractions
OPRK1 4986 NALOXONE HYDROCHLORIDE CHEMBL1718 antagonist ChemblInteractions
OPRK1 4986 HYDROCODONE BITARTRATE CHEMBL2062267 agonist ChemblInteractions
OPRK1 4986 ANILERIDINE HYDROCHLORIDE CHEMBL1201047 agonist ChemblInteractions
OPRK1 4986 PROPOXYPHENE CHEMBL1213351 TdgClinicalTrial, TEND
OPRK1 4986 CODEINE CHEMBL485 TdgClinicalTrial, TEND
OPRK1 4986 METHYLSAMIDORPHAN CHEMBL2364619 TdgClinicalTrial
OPRK1 4986 NALMEFENE HYDROCHLORIDE CHEMBL1201152 antagonist ChemblInteractions
OPRK1 4986 REMIFENTANIL CHEMBL1005 agonist DrugBank 19878098, 18325678
OPRK1 4986 CHEMBL2365680 CHEMBL2365680 agonist DrugBank 18325678

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
OPRK1 rs6985606 T naltrexone efficacy no No significant association between this variant and smoking quit rate when naltrexone was used as augmentation to nicotine patch therapy. Please note that alleles have been complemented to the positive strand. Allele T is not associated with response to naltrexone in people with Tobacco Use Disorder as compared to allele C. 31206155 1451114060
OPRK1 rs6473797 T oxycodone efficacy no No association between this variant and analgesic response to oxycodone, as assessed by cold pressor test, subjective effects of oxycodone. Allele T is not associated with response to oxycodone as compared to allele C. 31493434 1451121694
OPRK1 rs16918941 A naltrexone efficacy no No significant association between this variant and smoking quit rate when naltrexone was used as augmentation to nicotine patch therapy. Allele A is not associated with response to naltrexone in people with Tobacco Use Disorder as compared to allele G. 31206155 1451114014
OPRK1 rs997917 C naltrexone efficacy no No significant association between this variant and smoking quit rate when naltrexone was used as augmentation to nicotine patch therapy. Please note that alleles have been complemented to the positive strand. Allele C is not associated with response to naltrexone in people with Tobacco Use Disorder as compared to allele T. 31206155 1451114066
OPRK1 rs6985606 T heroin toxicity no No significant association between this variant and positive or negative response to first use of heroin. Allele T is not associated with response to heroin as compared to allele C. 28692418 1450827368
OPRK1 rs963549 CC methadone dosage yes The CC genotype was significantly less frequent in patients taking >45mg of methadone per day than in those taking <45mg methadone per day. Genotype CC is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes CT + TT. 31940240 1451138668
OPRK1 rs3808627 T methadone dosage no No significant difference in allele or genotype frequencies between patients taking >45mg of methadone per day and those taking <45mg methadone per day. Allele T is not associated with dose of methadone in people with Heroin Dependence as compared to allele C. 31940240 1451138721
OPRK1 rs3802279 CC methadone dosage yes The CC genotype was significantly less frequent in patients taking >45mg of methadone per day than in those taking <45mg methadone per day. Genotype CC is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes CT + TT. 31940240 1451138607
OPRK1 rs3802281 TT methadone dosage yes The TT genotype was significantly less frequent in patients taking >45mg of methadone per day than in those taking <45mg methadone per day. Genotype TT is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes CC + CT. 31940240 1451138662
OPRK1 rs16918842 T methadone dosage no No significant difference in allele or genotype frequencies between patients taking >45mg of methadone per day and those taking <45mg methadone per day. Allele T is not associated with dose of methadone in people with Heroin Dependence as compared to allele C. 31940240 1451138701
OPRK1 rs3802279 T heroin dosage no No significant difference in allele or genotype frequencies between patients who reported taking >0.5g of heroin per day and those who reported taking <0.5g heroin per day. Allele T is not associated with dose of heroin in people with Heroin Dependence as compared to allele C. 31940240 1451138759
OPRK1 rs963549 T heroin dosage no No significant difference in allele or genotype frequencies between patients who reported taking >0.5g of heroin per day and those who reported taking <0.5g heroin per day. Allele T is not associated with dose of heroin in people with Heroin Dependence as compared to allele C. 31940240 1451138781
OPRK1 rs3802281 C heroin dosage no No significant difference in allele or genotype frequencies between patients who reported taking >0.5g of heroin per day and those who reported taking <0.5g heroin per day. Allele C is not associated with dose of heroin in people with Heroin Dependence as compared to allele T. 31940240 1451138764
OPRK1 rs3808627 T heroin dosage no No significant difference in allele or genotype frequencies between patients who reported taking >0.5g of heroin per day and those who reported taking <0.5g heroin per day. Allele T is not associated with dose of heroin in people with Heroin Dependence as compared to allele C. 31940240 1451138773
OPRK1 rs16918842 T heroin dosage no No significant difference in allele or genotype frequencies between patients who reported taking >0.5g of heroin per day and those who reported taking <0.5g heroin per day. Allele T is not associated with dose of heroin in people with Heroin Dependence as compared to allele C. 31940240 1451138786
OPRK1 rs963549 T oxycodone efficacy no No association between this variant and analgesic response to oxycodone, as assessed by cold pressor test, subjective effects of oxycodone. Allele T is not associated with response to oxycodone as compared to allele C. 31493434 1451121699
OPRK1 rs1051660 A morphine "dosage","efficacy" yes Please note that alleles have been complemented to the positive strand. An association was observed between this variant and a patient's need to escalate their dose of morphine, but there was no association between this variant and a patient's initial dose requirement. Allele A is associated with decreased dose of morphine in people with Pain as compared to allele C. 29259946 1449182301
OPRK1 rs963549 C nalmefene efficacy no Allele C is not associated with response to nalmefene in people with Alcoholism as compared to allele T. 18537939 1449161532
OPRK1 rs1051660 A buprenorphine efficacy no No significant difference in allele or genotype frequencies between responders and non-responders to buprenorphine. Allele A is not associated with response to buprenorphine in people with Heroin Dependence as compared to allele C. 24274990 1450820814
OPRK1 rs16918909 G heroin toxicity no No significant association between this variant and positive or negative response to first use of heroin. The authors note that this variant was not in Hardy-Weinberg equilibrium in the study cohort. Allele G is not associated with response to heroin as compared to allele A. 28692418 1450827374
OPRK1 rs7813478 C heroin toxicity no No significant association between this variant and positive or negative response to first use of heroin. Allele C is not associated with response to heroin as compared to allele T. 28692418 1450827414
OPRK1 rs6473797 C naltrexone efficacy no No significant association between this variant and smoking quit rate when naltrexone was used as augmentation to nicotine patch therapy. Please note that alleles have been complemented to the positive strand. Allele C is not associated with response to naltrexone in people with Tobacco Use Disorder as compared to allele T. 31206155 1451114046