PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZDHHC17	1	SMARCB1	1	two hybrid	Butland SL (2014)	1
OTX2	3	LHX1	1	pull down	Nakano T (2000)	1
BCOR	2	OTX2	3	affinity chromatography technology	Oliviero G (2015)	1
SMARCB1	1	APP	1	pull down	Olah J (2011)	1
SMARCB1	1	OTX2	3	two hybrid	Daakour S (2016)	1
CDK4	2	OTX2	3	enzymatic study	Anders L (2011)	1
ZDHHC17	1	OTX2	3	two hybrid	Butland SL (2014)	1
LHX1	1	FOXA2	3	pull down	Foucher I (2003)	1
OTX2	3	FOXA2	3	pull down, pull down	Foucher I (2003), Nakano T (2000)	2
CDK4	2	APP	1	pull down	Olah J (2011)	1
POU5F1	0	OTX2	3	affinity chromatography technology	Oliviero G (2015)	1
NANOG	0	OTX2	3	affinity chromatography technology	Oliviero G (2015)	1
ATXN1	2	OTX2	3	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
OTX2	3	OTX2	3	pull down	Nakano T (2000)	1
OTX2	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2