PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
LYN	2	FBXO28	2	affinity chromatography technology	Zhu J (2013)	1
SOX2	4	CDK11A	1	affinity chromatography technology	Cox JL (2013)	1
SNW1	0	PPP1CA	3	affinity chromatography technology	Lleres D (2010)	1
H2AFX	1	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Lee HS (2010), Yang X (2010)	3
SH3KBP1	1	RAF1	3	affinity chromatography technology	Sato S (2013)	1
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
NCK2	2	BAIAP2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAS2R41	0	PAK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCK2	2	PAK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Braverman LE (1999), Cowan CA (2001), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
FGB	2	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
ARHGEF2	4	RAC1	7	pull down	Gao Y (2001)	1
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PAK1	2	MYNN	3	two hybrid	Bandyopadhyay S (2010)	1
PAK1	2	ZNF823	0	two hybrid	Bandyopadhyay S (2010)	1
PKLR	0	ARHGEF6	0	affinity chromatography technology	Brown MC (2002)	1
GIT1	10	GIT2	2	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Kim S (2003), Kim S (2003), Kim S (2003), Huttlin EL (2017)	4
NCK2	2	GIT1	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	LIMK1	3	enzymatic study	Kobayashi M (2006)	1
PPP1CA	3	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li L (2003), Xiao L (2010), Xiao L (2010), Xiao L (2010), Chen CS (2005), Chen CS (2005)	6
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
BMX	0	PAK1	2	affinity chromatography technology, affinity chromatography technology, pull down	Bagheri-Yarmand R (2001), Bagheri-Yarmand R (2001), Bagheri-Yarmand R (2001)	3
NCK2	2	ERBB2	6	unspecified method	Jones RB (2006)	1
PAK1	2	285464	0	two hybrid, pull down, affinity chromatography technology, pull down	Talukder AH (2006), Talukder AH (2006), Talukder AH (2006), Talukder AH (2006)	4
HIST1H3A	3	PPP1CA	3	affinity chromatography technology, pull down	Zhang H (2013), Zhang H (2013)	2
HSP90AA1	7	CHORDC1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Gano JJ (2010), Gano JJ (2010), Taipale M (2014), Taipale M (2014), Hein MY (2015)	6
PAK1	2	CHORDC1	1	two hybrid	Wasserman T (2010)	1
CDC42	3	MYO6	3	two hybrid	Bandyopadhyay S (2010)	1
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
HSP90AA1	7	LYN	2	affinity chromatography technology	Taipale M (2012)	1
GIT1	10	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Haendeler J (2003), Haendeler J (2003)	3
ARHGEF2	4	PLCG1	6	affinity chromatography technology	Swiercz JM (2009)	1
CDC42	3	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
ERBB2	6	ILKAP	2	two hybrid	Yao Z (2017)	1
ESR1	0	PPP2CA	7	affinity chromatography technology	Okada M (2015)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
PAK1	2	ERBB2	6	affinity chromatography technology	Adam L (1998)	1
RAC1	7	HIST1H3A	3	affinity chromatography technology	Sandrock K (2010)	1
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
FGB	2	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
NCK2	2	GIT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAK1	2	DYNLL1	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Wang J (2011)	7
PAK1	2	GIT2	2	affinity chromatography technology	So J (2015)	1
PAK1IP1	3	PAK1	2	two hybrid, affinity chromatography technology, pull down	Xia C (2001), Xia C (2001), Xia C (2001)	3
PAK1	2	ZBTB18	9	two hybrid	Bandyopadhyay S (2010)	1
EGFR	5	BAIAP2	6	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013)	4
PAK1	2	HSP90AA1	7	two hybrid	Bandyopadhyay S (2010)	1
PAK2	0	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
MAPK14	0	PAK1	2	affinity chromatography technology	Chan PM (2008)	1
MAPK14	0	DYRK1B	1	enzymatic study	Lee K (2000)	1
ARHGEF6	0	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	HSP90AA1	7	affinity chromatography technology	Yang X (2010)	1
AKT1	1	BAD	1	pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Wang X (2001), Deregibus MC (2002), Song JJ (2005), Song JJ (2005), Polzien L (2009), Urschel S (2005), Yuan ZQ (2005), Rena G (1999), Kim J (2013), Chen TC (2014)	10
TGFBR2	0	ERBB2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCK2	2	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAK1	2	YWHAG	5	two hybrid	Bandyopadhyay S (2010)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
AKT1	1	PPM1A	1	imaging technique	Chen TC (2014)	1
PAK1	2	C5orf42	0	two hybrid	Bandyopadhyay S (2010)	1
ABI3	1	PAK1	2	pull down	Ichigotani Y (2002)	1
EGFR	5	ILKAP	2	two hybrid	Yao Z (2017)	1
GNB1	4	PAK1	2	affinity chromatography technology, affinity chromatography technology	Li Z (2003), Li Z (2003)	2
LPXN	4	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	HIST1H3A	3	affinity chromatography technology, imaging technique	Lee HS (2010), Soldi M (2013)	2
PAK1	2	HGS	5	pull down	Sasaki Y (2001)	1
BAIAP2	6	CDC42	3	far western blotting, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Soltau M (2002), Krugmann S (2001), Krugmann S (2001), Miki H (2000), Bandyopadhyay S (2010), Govind S (2001), Govind S (2001)	7
HSP90AA1	7	FBXO28	2	affinity chromatography technology	Taipale M (2012)	1
RAF1	3	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, pull down	Karandikar M (2000), Karandikar M (2000), Karandikar M (2000)	3
PAK2	0	APP	1	pull down	Olah J (2011)	1
PAK1	2	CDK11A	1	two hybrid, pull down, affinity chromatography technology	Chen S (2003), Chen S (2003), Chen S (2003)	3
PAK1	2	APP	1	pull down	Olah J (2011)	1
ARHGEF6	0	FBXO28	2	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
PLCG1	6	ERBB2	6	affinity chromatography technology, biochemical, unspecified method	Peles E (1991), Arteaga CL (1991), Jones RB (2006)	3
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
DYRK1B	1	DYNLL1	0	affinity chromatography technology	Varjosalo M (2013)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
CDK5	0	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
PLCG1	6	PAK1	2	pull down	Shin KS (2002)	1
GIT2	2	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
LPXN	4	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
CDK5	0	PAK1	2	enzymatic study, affinity chromatography technology	Rashid T (2001), Rashid T (2001)	2
PPP2CA	7	PAK1	2	enzymatic study	Chan PM (2008)	1
TGM2	2	YWHAG	5	biochemical	Kristensen AR (2012)	1
AKT1	1	MAPK14	0	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Rane MJ (2001), Rane MJ (2001), Hartman AD (2006), Rane MJ (2001), Rane MJ (2001), Ivanov AA (2017)	6
ILKAP	2	PAK1	2	biochemical	Wan C (2015)	1
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
NCK2	2	PAK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	ARHGEF7	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PAK1	2	BAD	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Jin S (2005), Polzien L (2009), Yuan ZQ (2005), Schuermann A (2000)	4
ERBB2	6	BMX	0	unspecified method	Jones RB (2006)	1
LYN	2	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
FBXO28	2	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	ARHGEF2	4	affinity chromatography technology	Lleres D (2010)	1
PAK2	0	MYO6	3	biochemical	Wan C (2015)	1
RAF1	3	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PAK1	2	MAP3K1	4	enzymatic study	Gallagher ED (2002)	1
ICAM1	6	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
RAC1	7	PPP2CA	7	affinity chromatography technology	ten Klooster JP (2007)	1
FBXO28	2	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR2	0	SH3KBP1	1	affinity chromatography technology	Yakymovych I (2015)	1
PAK1	2	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
SNW1	0	PAK1	2	affinity chromatography technology	Lleres D (2010)	1
EGFR	5	SETX	7	affinity chromatography technology	Yao Z (2017)	1
CDC42	3	ARHGEF6	0	affinity chromatography technology, imaging technique	Feng Q (2004), Chen TC (2014)	2
EGFR	5	PPM1A	1	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
SETX	7	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
TGM2	2	YWHAZ	1	biochemical	Kristensen AR (2012)	1
SOX2	4	YWHAZ	1	affinity chromatography technology	Cox JL (2013)	1
ARPC1B	1	APP	1	pull down	Olah J (2011)	1
ICAM1	6	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
PAK1	2	ZNF83	1	two hybrid	Bandyopadhyay S (2010)	1
BAD	1	PPP1CA	3	affinity chromatography technology	Flores-Delgado G (2007)	1
RHOJ	0	PAK1	2	two hybrid, affinity chromatography technology	Vignal E (2000), Huttlin EL (2017)	2
TGFBR2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PAK1	2	PAK2	0	affinity chromatography technology	Varjosalo M (2013)	1
ABI3	1	PAK2	0	pull down	Ichigotani Y (2002)	1
CDC42	3	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
PAK1	2	TGFBR2	0	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
ICAM1	6	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
PAK1	2	CDC42	3	pull down, pull down, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Seoh ML (2003), Zhang B (1998), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Morreale A (2000), Wells CD (2006), Marivin A (2013), Varjosalo M (2013), Shen Y (2008), Gonzalez-Martinez D (2004)	11
MAPK14	0	PAK2	0	affinity chromatography technology	Chan PM (2008)	1
ILKAP	2	PAK2	0	biochemical	Wan C (2015)	1
NCK2	2	NCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PYCARD	1	PAK1	2	affinity chromatography technology	Kotlyar M (2015)	1
NCK2	2	ARHGEF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRSK1	3	PAK1	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Nie J (2012), Nie J (2012), Nie J (2012), Nie J (2012)	4
PAK2	0	ARHGEF7	3	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Hein MY (2015)	2
PAK1	2	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
PPP2CA	7	PPAT	0	biochemical	Wan C (2015)	1
YWHAZ	1	BAD	1	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang H (2001), Yang H (2001), Bandyopadhyay S (2010), Liang X (2010), Subramanian RR (2001), Polzien L (2009), Wang J (2011), Jin L (2009), Mortenson JB (2015), Dong S (2007)	10
RAC1	7	ARHGEF6	0	affinity chromatography technology, affinity chromatography technology	Sandrock K (2010), Feng Q (2004)	2
EGFR	5	ICAM1	6	affinity chromatography technology	Wu SL (2006)	1
PAK2	0	TGM2	2	biochemical	Kristensen AR (2012)	1
MAPK14	0	EGFR	5	enzymatic study	Raingeaud J (1995)	1
PAK1	2	RELA	1	affinity chromatography technology	Dammann K (2015)	1
PAK1	2	ZNF418	2	two hybrid	Bandyopadhyay S (2010)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
ILKAP	2	MAPK14	0	enzymatic study	Zhang X (2017)	1
BMX	0	APP	1	pull down	Olah J (2011)	1
ICAM1	6	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
ARHGEF6	0	PAK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013), Huttlin EL (2017)	3
AKT1	1	RAF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zimmermann S (1999), Zimmermann S (1999), Wang J (2009), Wang J (2009), Ivanov AA (2017)	5
TGFBR1	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Yakymovych I (2015), Yakymovych I (2015)	2
PAK1	2	HIST1H3A	3	enzymatic study, pull down	Li F (2002), Li F (2002)	2
PAK2	0	GIT2	2	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Hein MY (2015)	2
PAK1	2	HIST1H4A	0	enzymatic study	Phee H (2005)	1
PAK1	2	ARPC1B	1	affinity chromatography technology, pull down, affinity chromatography technology	Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004)	3
RAC1	7	GIT1	10	affinity chromatography technology	Sandrock K (2010)	1
PAK1	2	MYO6	3	enzymatic study	Buss F (1998)	1
FSD1	3	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR1	2	MAPK14	0	affinity chromatography technology	Sorrentino A (2008)	1
PAK1	2	LIMK1	3	affinity chromatography technology, pull down	Edwards DC (1999), Edwards DC (1999)	2
PAK2	0	SORBS3	5	pull down, two hybrid, two hybrid	Kaerkkaeinen S (2006), Rolland T (2014), Yu H (2011)	3
RELA	1	PPP2CA	7	pull down	Yang J (2001)	1
SLC25A41	0	LYN	2	affinity chromatography technology	Huttlin EL (2015)	1
PAK1	2	ESR1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Rayala SK (2006), Wang RA (2002), Wang RA (2002), Wang RA (2002)	4
YWHAZ	1	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Zippo A (2009), Macdonald N (2005), Macdonald N (2005), Macdonald N (2005), Macdonald N (2005)	5
ESR1	0	GNB1	4	affinity chromatography technology, affinity chromatography technology	Tarallo R (2011), Han SJ (2016)	2
SNW1	0	HSP90AA1	7	affinity chromatography technology	Lleres D (2010)	1
ARHGEF2	4	YWHAZ	1	affinity chromatography technology	Yamahashi Y (2011)	1
AKT1	1	PPP2CA	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Beaulieu JM (2008), Beaulieu JM (2008), Calvo N (2010), Calvo N (2010), Xiao L (2010), Guo J (2016), Guo J (2016), Guo J (2016)	8
SORBS3	5	AKT1	1	affinity chromatography technology, two hybrid, pull down, enzymatic study	Yuan ZQ (2005), Yuan ZQ (2005), Yuan ZQ (2005), Yuan ZQ (2005)	4
SOX2	4	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
SOX2	4	PAK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAK2	0	CDC42	3	unspecified method, pull down, pull down, two hybrid, pull down, two hybrid	Stevens WK (1999), Abo A (1998), Zhang B (1998), Bandyopadhyay S (2010), Kaerkkaeinen S (2010), Rolland T (2014)	6
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
PKLR	0	PAK1	2	affinity chromatography technology	Brown MC (2002)	1
AKT1	1	YWHAG	5	affinity chromatography technology	Klein JB (2005)	1
HGS	5	SH3KBP1	1	affinity chromatography technology	Ronning SB (2011)	1
PPM1A	1	PAK1	2	enzymatic study	Chan PM (2008)	1
GIT2	2	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
RELA	1	TGM2	2	affinity chromatography technology, imaging technique	Kumar S (2012), Kumar S (2012)	2
EGFR	5	BMX	0	unspecified method	Jones RB (2006)	1
YWHAZ	1	PAK2	0	biochemical	Kristensen AR (2012)	1
ICAM1	6	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PPP1CA	3	PAK2	0	affinity chromatography technology	Zhang H (2013)	1
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
PAK2	0	GIT1	10	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Hein MY (2015)	2
ARHGEF6	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
RHOU	0	PAK1	2	pull down, pull down	Dart AE (2015), Dart AE (2015)	2
DYNLL2	0	PAK1	2	two hybrid	Wang J (2011)	1
LPXN	4	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
GIT1	10	ARHGEF6	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Bagrodia S (1999), Vinayagam A (2011), Huttlin EL (2017)	3
EGFR	5	ARHGEF2	4	affinity chromatography technology	Tong J (2014)	1
FBXO28	2	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
YWHAG	5	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Autieri MV (1999), Van Der Hoeven PC (2000), Rajalingam K (2005), Zhu J (2005), So J (2015), Ivanov AA (2017)	7
PAK1	2	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2006)	1
HSP90AA1	7	TGFBR1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012), Antonov AS (2012)	6
PPAT	0	PAK1	2	biochemical	Wan C (2015)	1
AKT1	1	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang Y (2006), Wang Y (2006), Wang Y (2006), Wang Y (2006)	4
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
AKT1	1	PAK1	2	pull down, pull down	Vadlamudi RK (2004), Joshi S (2014)	2
PAK1	2	ARHGEF2	4	affinity chromatography technology, pull down	Zenke FT (2004), Zenke FT (2004)	2
PAK1	2	RAC1	7	pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Katoh H (2003), Seoh ML (2003), Zhang B (1998), Bandyopadhyay S (2010), Neri P (2011), Wu Y (2005), Jing J (2009), Qu X (2005), Matos P (2006), Wells CD (2006), Edlund S (2004), Sandrock K (2010), Miki H (2000), Higashi M (2009), Feng H (2015), Gonzalez-Martinez D (2004), Hou Y (2004), Eller-Borges R (2015), Pop M (2004)	19
EGFR	5	PAK1	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
285464	0	ESR1	0	affinity chromatography technology	Talukder AH (2006)	1
YWHAZ	1	LIMK1	3	two hybrid, pull down	Birkenfeld J (2003), Birkenfeld J (2003)	2
BAIAP2	6	APP	1	pull down	Olah J (2011)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
ESR1	0	PPP1CA	3	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
ELF3	0	RELA	1	affinity chromatography technology	Longoni N (2013)	1
HSP90AA1	7	BMX	0	affinity chromatography technology	Taipale M (2012)	1
SH3KBP1	1	FBXO28	2	affinity chromatography technology	Huttlin EL (2017)	1
BAIAP2	6	RAC1	7	pull down, pull down, affinity chromatography technology	Miki H (2000), Miki H (2000), Govind S (2001)	3
ESR1	0	ERBB2	6	affinity chromatography technology	Yang Z (2004)	1
RAC1	7	PAK2	0	pull down, two hybrid, pull down	Zhang B (1998), Bandyopadhyay S (2010), Kaerkkaeinen S (2010)	3
LPXN	4	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
RELA	1	MAPK14	0	two hybrid	Vinayagam A (2011)	1
NCK1	0	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	6
PAK1	2	MYLK	3	enzymatic study	Sanders LC (1999)	1
CDC42	3	ARHGEF7	3	affinity chromatography technology, pull down	Wu WJ (2003), Wu WJ (2003)	2
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
AKT1	1	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klein JB (2005), Xiong Y (2009), Xiong Y (2009)	3
ESR1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Olivier S (2006), Nettles KW (2008), Nettles KW (2008), Rubio MF (2006), Rubio MF (2006)	5
ARHGEF6	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
HIST1H3A	3	YWHAG	5	affinity chromatography technology, pull down	Macdonald N (2005), Macdonald N (2005)	2
YWHAG	5	BAIAP2	6	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
SLC25A41	0	PAK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	CDK5	0	affinity chromatography technology	Tong J (2014)	1
LIMK1	3	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	CDK11A	1	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Huttlin EL (2017)	2
H2AFX	1	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Yang X (2010), Yang X (2010)	2
LPXN	4	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
PPP2CA	7	ARHGEF2	4	affinity chromatography technology	St-Denis N (2016)	1
H2AFX	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Dittmann K (2011), Yao Z (2017)	2
MAP3K1	4	DYRK1B	1	affinity chromatography technology	Ritterhoff S (2010)	1
BAIAP2	6	PAK1	2	pull down	Miki H (2000)	1
RAF1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stancato LF (1993), Dogan T (2008), Mollapour M (2010), Du J (2006), Maloney A (2007), Fiskus W (2007), Giommarelli C (2010), Arlander SJ (2006), ONeill E (2004), Taipale M (2012), Zhu J (2005), Schneider C (1996), Mollapour M (2014), Atabakhsh E (2012), Mitra S (2016)	15
ERBB2	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ESR1	0	MYO6	3	affinity chromatography technology	Tarallo R (2011)	1
GIT1	10	ARHGEF7	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim S (2003), Kim S (2003), Bagrodia S (1999), Huttlin EL (2017)	4
TGM2	2	APP	1	pull down	Olah J (2011)	1
TGM2	2	PAK1	2	two hybrid	Vinayagam A (2011)	1
LIMK1	3	BAD	1	affinity chromatography technology	Hein MY (2015)	1
DYNLL2	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
RAF1	3	BAD	1	enzymatic study, enzymatic study, imaging technique	Jin S (2005), Polzien L (2009), Chen TC (2014)	3
SH3KBP1	1	PAK2	0	affinity chromatography technology, far western blotting	Kurakin AV (2003), Kurakin AV (2003)	2
PAK1	2	SORBS3	5	pull down, affinity chromatography technology	Yuan ZQ (2005), Yuan ZQ (2005)	2
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
MAP3K1	4	HGS	5	enzymatic study	Charlaftis N (2014)	1
PAK1	2	TGFBR1	2	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
ARHGEF6	0	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Feng Q (2004), Huttlin EL (2017)	2
PPP1CA	3	PAK1	2	enzymatic study	Chan PM (2008)	1
ICAM1	6	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
OR2K2	2	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
DYNLL1	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
HGS	5	ILKAP	2	pull down	Pridgeon JW (2009)	1
PAK1	2	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Ku GM (2001), Schmidt MH (2006), Bandyopadhyay S (2010), Varjosalo M (2013), Huttlin EL (2017)	5
AKT1	1	YWHAZ	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Powell DW (2002), Powell DW (2002), Powell DW (2002), Klein JB (2005)	4
FSD1	3	PAK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAK1	2	RAF1	3	affinity chromatography technology, pull down, enzymatic study	Zang M (2002), Zang M (2002), Zang M (2002)	3
HSP90AA1	7	LIMK1	3	affinity chromatography technology	Taipale M (2012)	1
AKT1	1	RAC1	7	enzymatic study	Kwon T (2000)	1
NCK1	0	PAK1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ku GM (2001), Braverman LE (1999), Bokoch GM (1996), Bokoch GM (1996), Izadi KD (1998), Wunderlich L (1999), Cowan CA (2001)	7
YWHAG	5	MAP3K1	4	affinity chromatography technology	Sun BK (2011)	1
ELF3	0	ERBB2	6	genetic interference	Asada S (2002)	1
PPM1A	1	PAK2	0	enzymatic study	Chan PM (2008)	1
CDK5	0	CHORDC1	1	affinity chromatography technology	Boldt K (2016)	1
ERBB2	6	PPM1A	1	two hybrid	Yao Z (2017)	1
NCK2	2	ABI3	1	two hybrid	Rolland T (2014)	1
RAC1	7	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Sandrock K (2010), Feng Q (2004)	2
PAK1	2	GIT1	10	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015)	2
YWHAG	5	BAD	1	two hybrid	Bandyopadhyay S (2010)	1
YWHAZ	1	HIST1H4A	0	affinity chromatography technology	Zippo A (2009)	1
LPXN	4	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
PAK1	2	DYRK1B	1	two hybrid	Bandyopadhyay S (2010)	1
YWHAG	5	ARHGEF2	4	affinity chromatography technology	Jin J (2004)	1
PAK1	2	H2AFX	1	affinity chromatography technology	So J (2015)	1
PAK2	0	YWHAG	5	biochemical	Kristensen AR (2012)	1
LYN	2	PAK1	2	affinity chromatography technology	Zhu J (2013)	1
PAK1	2	PAK1	2	affinity chromatography technology, biochemical, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Parrini MC (2002), Parrini MC (2002), Lei M (2000), Parrini MC (2002), Talukder AH (2006), Chan PM (2008)	6
PAK1	2	ELF3	0	enzymatic study, pull down	Manavathi B (2007), Manavathi B (2007)	2
HSP90AA1	7	DYRK1B	1	affinity chromatography technology	Taipale M (2012)	1
PAK2	0	RHOJ	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
RAF1	3	PPP2CA	7	affinity chromatography technology	Rajalingam K (2005)	1
HSP90AA1	7	TGFBR2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012)	5
ESR1	0	H2AFX	1	affinity chromatography technology	Tarallo R (2011)	1
PAK1	2	ZC3H7A	2	two hybrid	Bandyopadhyay S (2010)	1