PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DEF6	0	RAC2	0	pull down	Mavrakis KJ (2004)	1
DEF6	0	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLSCR1	0	APP	1	pull down	Olah J (2011)	1
DEF6	0	RHOA	0	pull down	Mavrakis KJ (2004)	1
BABAM2	2	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009)	17
RCC2	0	RAC1	7	affinity chromatography technology	Williamson RC (2014)	1
DEF6	0	NFKB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLSCR1	0	CDC42EP1	1	two hybrid	Rual JF (2005)	1
BABAM2	2	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Hu X (2011), Hu X (2011), Kristensen AR (2012), Zhang J (2014), Yan K (2015), Zheng H (2013)	8
DEF6	0	PRKCQ	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	BEGAIN	3	two hybrid	Rual JF (2005)	1
ADD2	2	APP	1	pull down	Olah J (2011)	1
DEF6	0	RAC1	7	pull down	Mavrakis KJ (2004)	1
DEF6	0	PBXIP1	1	two hybrid	Rolland T (2014)	1
TCF4	26	DEF6	0	two hybrid	Rolland T (2014)	1
RCC2	0	CDC42	3	affinity chromatography technology	Williamson RC (2014)	1
DEF6	0	ADD2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	CHAMP1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	APP	1	pull down	Olah J (2011)	1
DEF6	0	GRID1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	MYCBP2	11	affinity chromatography technology	Huttlin EL (2015)	1
DEF6	0	RBM45	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	DCXR	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	HOMEZ	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
DCXR	1	APP	1	pull down	Olah J (2011)	1
DEF6	0	CDC42	3	pull down	Mavrakis KJ (2004)	1
PTK2	2	APP	1	pull down	Olah J (2011)	1
BRCC3	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2010), Kristensen AR (2012), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	12
DEF6	0	ANKS1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	KBTBD6	0	affinity chromatography technology	Huttlin EL (2015)	1
BEGAIN	3	APP	1	pull down	Olah J (2011)	1
CDC42	3	CDC42EP1	1	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Bandyopadhyay S (2010), Wang J (2011), Rolland T (2014)	4
CDC42EP1	1	DEF6	0	two hybrid	Rolland T (2014)	1
DEF6	0	RCC2	0	affinity chromatography technology	Huttlin EL (2017)	1
BABAM1	1	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hu X (2011), Hu X (2011), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	9
BRCC3	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017)	14
BABAM2	2	BABAM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	21
DEF6	0	EIF4ENIF1	1	two hybrid	Rolland T (2014)	1
RAC1	7	PTK2	2	two hybrid	Bandyopadhyay S (2010)	1
DEF6	0	SMARCA1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	ARHGAP42	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLSCR1	0	DEF6	0	two hybrid	Rolland T (2014)	1
PTK2	2	DEF6	0	two hybrid	Rolland T (2014)	1
DEF6	0	C1orf52	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	DCAF16	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	BABAM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	BRCC3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	TNRC6C	3	affinity chromatography technology	Huttlin EL (2017)	1