PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RALB	0	PAM	2	affinity chromatography technology	Huttlin EL (2017)	1
DPEP2	3	TAZ	1	affinity chromatography technology	Huttlin EL (2017)	1
IDS	0	TAZ	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTCH1	8	PAM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAM	2	TSC1	4	imaging technique	Murthy V (2004)	1
B3GNT2	1	PAM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DKKL1	1	PAM	2	affinity chromatography technology	Huttlin EL (2017)	1
TSC2	17	CALM1	0	far western blotting, pull down, unspecified method, pull down	Noonan DJ (2002), Noonan DJ (2002), Noonan DJ (2002), York B (2005)	4
SERPINA6	0	PAM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IDS	0	PAM	2	affinity chromatography technology	Huttlin EL (2015)	1
ART3	1	PAM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GLP1R	4	PAM	2	protein complementation assay	Dai FF (2015)	1
TMEM25	0	TAZ	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC2	17	PAM	2	two hybrid, affinity chromatography technology, imaging technique	Murthy V (2004), Murthy V (2004), Murthy V (2004)	3
TAZ	1	PAM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CALM1	0	PAM	2	pull down	Shen X (2005)	1
PAM	2	RASSF9	0	two hybrid, pull down	Chen L (1998), Chen L (1998)	2
DPEP2	3	PAM	2	affinity chromatography technology	Huttlin EL (2015)	1
TSC2	17	TSC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dan HC (2002), Hodges AK (2001), Aicher LD (2001), van Slegtenhorst M (1998), Nellist M (2002), Li Y (2004), Mak BC (2003), van Slegtenhorst M (1998), van Slegtenhorst M (1998), Ma L (2005), Cai SL (2006), Cao Y (2006), Ma L (2005), Inoki K (2003), Nellist M (2005), Goncharova EA (2006), Astrinidis A (2006), Cao Y (2006), Astrinidis A (2003), Hodges AK (2001), Hodges AK (2001), Nellist M (2001), Aicher LD (2001), Murthy V (2000), van Slegtenhorst M (1998), Dan HC (2002), Miloloza A (2000), Nakashima A (2007), Nakashima A (2007), Benvenuto G (2000), Chong-Kopera H (2006), York B (2005), Vega-Rubin-de-Celis S (2010), Vega-Rubin-de-Celis S (2010), Lin Y (2011), Cloutier P (2017), Cloutier P (2017)	37
GAA	3	PAM	2	affinity chromatography technology	Huttlin EL (2017)	1
UBR2	8	PAM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CALM1	0	RALB	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Clough RR (2002), Clough RR (2002), Clough RR (2002), Clough RR (2002)	4
KALRN	7	PAM	2	two hybrid, two hybrid	Alam MR (1997), Alam MR (1997)	2
SUSD4	6	PAM	2	affinity chromatography technology	Huttlin EL (2015)	1
TMEM25	0	PAM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2