PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	RB1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, pull down, affinity chromatography technology, genetic interference	Aprelikova ON (1999), Fan S (2001), Fan S (2001), Fan S (2001), Yarden RI (1999), Aprelikova ON (1999), Aprelikova ON (1999), Shen JP (2017)	8
BBS1	2	BBS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
PAX2	2	KLK6	2	two hybrid	Arroyo R (2015)	1
PAX2	2	PAXIP1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Lechner MS (2000), Lechner MS (2000), Lechner MS (2000), Lechner MS (2000)	4
BBS1	2	BBS7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
BBS7	2	PAX2	2	two hybrid	Oeffner F (2008)	1
RB1	2	MAPK8	3	affinity chromatography technology	Li H (2001)	1
BBS2	1	PAX2	2	two hybrid	Oeffner F (2008)	1
PAX2	2	BLID	0	two hybrid	Arroyo R (2015)	1
RB1	2	PAX2	2	affinity chromatography technology	Yuan SS (2002)	1
BRCA1	7	PAX2	2	affinity chromatography technology	Gorski JJ (2011)	1
BBS1	2	BBS4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
PAX2	2	GLCE	0	two hybrid	Arroyo R (2015)	1
BBS7	2	BBS4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
PAX2	2	KLK9	1	two hybrid	Arroyo R (2015)	1
MAPK8	3	PAX2	2	enzymatic study	Cai Y (2002)	1
PAX2	2	VPS45	0	two hybrid	Arroyo R (2015)	1
PAX2	2	NSD3	6	two hybrid	Arroyo R (2015)	1
PAX2	2	RASL10B	0	two hybrid	Arroyo R (2015)	1
PAX2	2	SNAI1	1	two hybrid	Arroyo R (2015)	1
PAX2	2	BEX1	0	two hybrid	Arroyo R (2015)	1
BBS2	1	BBS4	2	affinity chromatography technology	Boldt K (2016)	1
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
BBS7	2	BBS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
BBS4	2	PAX2	2	two hybrid	Oeffner F (2008)	1
PAX2	2	MRC2	3	two hybrid	Arroyo R (2015)	1
PAX2	2	PRDM14	1	two hybrid	Arroyo R (2015)	1
MAPK8IP1	7	MAPK8	3	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Whitmarsh AJ (1998), Cai Y (2002), Ho DT (2006), Song JJ (2005), Blanco S (2008), Blanco S (2008), Nishitani Y (2006), Huttlin EL (2017)	8
MAPK8IP1	7	PAX2	2	affinity chromatography technology	Cai Y (2002)	1
BBS1	2	PAX2	2	two hybrid	Oeffner F (2008)	1
PAX2	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
PAX2	2	IL13RA2	0	two hybrid	Arroyo R (2015)	1
TRIM25	5	RASL10B	0	affinity chromatography technology	Choudhury NR (2017)	1