PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS3	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
DTL	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Higa LA (2006), Higa LA (2006), Sertic S (2013), Shibata E (2014), Hein MY (2015), Shibata E (2011), Higa LA (2006), Higa LA (2006)	9
FBXO7	1	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
DCAF8	1	COPS7A	0	biochemical	Kristensen AR (2012)	1
DDA1	1	DCAF8	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
VCP	6	UBE2M	0	affinity chromatography technology	Yu CC (2013)	1
COPS8	2	COPS7A	0	biochemical, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Huang X (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
FBXO7	1	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPRE1	0	PRKAR2B	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015)	3
DDA1	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Jin J (2006), Hein MY (2015)	3
DENR	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Ohta T (2001), Saiga T (2009), Rodier G (2008), Zhou W (2014), Zhou W (2014)	6
DCAF1	5	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn J (2010), Belzile JP (2007), He YJ (2006), McCall CM (2008), McCall CM (2008), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Kyei GB (2015)	14
DDB1	6	COPS6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009)	5
COPS7A	0	KCTD20	2	affinity chromatography technology	Hein MY (2015)	1
DCUN1D1	0	COPS3	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CRBN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Ito T (2010), Bennett EJ (2010), Liu Y (2015), Liu Y (2015), Diaz-Rodriguez E (2016), Xu Q (2016), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Eichner R (2016), Eichner R (2016), Huttlin EL (2017), Kroenke J (2014)	14
GPS1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Stotland A (2012), Huang X (2005), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
COPS2	5	DCAF4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APBB3	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
SLX4IP	3	FBXW4	0	affinity chromatography technology	Svendsen JM (2009)	1
UBE2M	0	RHOBTB1	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	DCAF4	3	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
COPS3	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
COPS5	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	11
COPS7A	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015), Huttlin EL (2017)	3
DDB1	6	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006)	2
RBX1	2	CUL2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Dias DC (2002), Ohta T (1999), Ohta T (1999), Maine GN (2007), Hu J (2004), Furukawa M (2002), Mao X (2011), Sufan RI (2006), Sufan RI (2006), Sufan RI (2006), Brower CS (2002), Tron AE (2012), Kamura T (2004), Kristensen AR (2012), Costessi A (2011), Huang DT (2009), Kamura T (1999), Kamura T (1999), Xu J (2015), Cardote TAF (2017)	20
COPS4	0	COPS7B	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
COPS4	0	CRBN	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kroenke J (2014)	2
DDB1	6	DCAF10	2	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006)	2
ERCC8	1	VCP	6	affinity chromatography technology	He J (2016)	1
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
COPS7A	0	DCAF4	3	affinity chromatography technology	Hein MY (2015)	1
FBXO6	0	COPS5	0	affinity chromatography technology	Liu B (2012)	1
IKBKB	1	COPS5	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Orel L (2010), Orel L (2010), Orel L (2010), Orel L (2010), Asare Y (2013), Asare Y (2013)	6
PRKD1	7	COPS5	0	enzymatic study	Uhle S (2003)	1
CSNK2B	5	ERCC8	1	two hybrid	Vinayagam A (2011)	1
DDB1	6	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down	Angers S (2006), Jin J (2006), Emberley ED (2012)	3
VCP	6	RAF1	3	affinity chromatography technology	Yu CC (2013)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
DCAF8	1	COPS2	5	affinity chromatography technology	Olma MH (2009)	1
CUL3	17	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	4
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
COPS5	0	FBXL14	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	PRMT5	3	affinity chromatography technology	Bennett EJ (2010)	1
FBXW4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2003), Lockwood WW (2013), Chung FZ (2014), Low TY (2014), Reitsma JM (2017)	5
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
COPS6	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CRBN	2	COPS7B	0	affinity chromatography technology	Kroenke J (2014)	1
COPS7A	0	CSN2	0	affinity chromatography technology	Luke-Glaser S (2007)	1
SKP2	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Nie L (2011), Bennett EJ (2010)	2
DCAF11	2	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
CUL4A	2	BTRC	1	affinity chromatography technology	He YJ (2006)	1
RAF1	3	COPS5	0	affinity chromatography technology	Hein MY (2015)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
CUL5	1	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	ERCC8	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CSN1S1	0	affinity chromatography technology	Fang L (2008)	1
NEDD8	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
ERCC8	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Olma MH (2009)	3
GRK5	7	COPS7A	0	affinity chromatography technology	Wu Z (2012)	1
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Enchev RI (2010), Olma MH (2009), Havugimana PC (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017)	6
DCUN1D1	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
APBB3	2	RHOBTB1	0	affinity chromatography technology	Huttlin EL (2017)	1
IKBKB	1	CUL1	7	affinity chromatography technology	Orel L (2010)	1
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Bennett EJ (2010), Sertic S (2013), Rossi M (2013), Jin J (2006), Shibata E (2011), Higa LA (2006)	7
CUL3	17	RHOBTB1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Berthold J (2008), Berthold J (2008), Berthold J (2008), Pelham CJ (2012), Pelham CJ (2012), Ibeawuchi SR (2015)	7
CTTN	1	COPS7A	0	biochemical	Wan C (2015)	1
RFWD2	0	DDB2	1	affinity chromatography technology	Olma MH (2009)	1
COPS5	0	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
DDA1	1	DCAF10	2	affinity chromatography technology	Olma MH (2009)	1
KLHL10	1	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
DDIT3	1	CUL3	17	affinity chromatography technology, biochemical	Huang X (2012), Huang X (2012)	2
LRR1	1	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
COPS2	5	COPS4	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huang X (2005), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
DTL	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006)	2
CSNK2A1	15	COPS5	0	affinity chromatography technology	Bhansali M (2014)	1
DDB1	6	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Min KW (2005), Emberley ED (2012), Olma MH (2009)	5
KLHL10	1	CUL3	17	affinity chromatography technology	Huttlin EL (2017)	1
COPS3	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
DDB2	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, imaging technique	Kapetanaki MG (2006), Takedachi A (2010), Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Matsumoto S (2015), Hein MY (2015), Groisman R (2006), Groisman R (2006), Chitale S (2017)	10
COPS6	0	COPS4	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	14
FBXO6	0	GPS1	1	affinity chromatography technology	Liu B (2012)	1
FBXW4	0	COPS7B	0	affinity chromatography technology	Lockwood WW (2013)	1
COPS5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Bennett EJ (2010), Oh W (2006), Chun Y (2013), Chun Y (2013), Chun Y (2013), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
CUL3	17	CTTN	1	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	4
DET1	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
MAPRE1	0	COPS8	2	pull down	Peth A (2007)	1
FBXW4	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
DCUN1D1	0	DCAF1	5	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	4
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
DCAF8	1	COPS3	1	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
DET1	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Wertz IE (2004), Vitari AC (2011), Lu G (2014), Lu G (2014), Pick E (2007), Huttlin EL (2017)	7
DDIT3	1	CSNK2A1	15	pull down, enzymatic study	Ubeda M (2003), Ubeda M (2003)	2
COPS8	2	COPS3	1	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Min KW (2005), Enchev RI (2010), Sharon M (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
IKBKB	1	COPS4	0	two hybrid, affinity chromatography technology	Orel L (2010), Orel L (2010)	2
RAB40AL	1	CUL5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS8	2	COPS2	5	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Yang X (2002), Huang X (2005), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
CUL2	3	WDR77	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Pick E (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006)	7
RBX1	2	CUL4B	8	affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, imaging technique	Dias DC (2002), Ji Q (2014), Huang DT (2009), Hein MY (2015), Yang Y (2015)	5
GPS1	1	SKP2	2	affinity chromatography technology	Lyapina S (2001)	1
NEDD8	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
DET1	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), McCall CM (2008), Bennett EJ (2010), Olma MH (2009)	4
ERCC8	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Groisman R (2006)	8
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
COPS7A	0	CSN3	1	affinity chromatography technology, affinity chromatography technology	Peth A (2007), Luke-Glaser S (2007)	2
KLHL10	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	FBXW11	2	affinity chromatography technology	Li JM (2013)	1
DDB1	6	DCAF11	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Angers S (2006), Jin J (2006), He YJ (2006), Olma MH (2009), Jin J (2006), Huttlin EL (2017), Lo JY (2017)	8
COPS7A	0	CCDC82	2	affinity chromatography technology	Hein MY (2015)	1
COPS2	5	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Huang X (2005), Bennett EJ (2010), Olma MH (2009), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	6
COPS6	0	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
COPS5	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Sertic S (2013), Higa LA (2006), Higa LA (2006)	5
RFWD2	0	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
CUL5	1	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
EPB41L1	4	COPS3	1	biochemical	Kristensen AR (2012)	1
CUL4A	2	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Kapetanaki MG (2006), Matsuda N (2005), Higa LA (2006), Nag A (2001), Takedachi A (2010), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), Groisman R (2003), Groisman R (2003), Hrecka K (2007), Shiyanov P (1999), Shiyanov P (1999), Bennett EJ (2010), Kulaksiz G (2005), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Groisman R (2003), Huttlin EL (2015), Hein MY (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Fantini D (2017)	31
COPS7A	0	NFE2L2	1	pull down	Wang Y (2002)	1
COPS7A	0	PTGS2	0	affinity chromatography technology, pull down	Neuss H (2007), Neuss H (2007)	2
COPS7A	0	WDR77	2	biochemical	Kristensen AR (2012)	1
COPS3	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Yang X (2002), Enchev RI (2010), Huang X (2005), Kapelari B (2000), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Rozen S (2015), Huttlin EL (2017)	13
CRBN	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Q (2016), Eichner R (2016), Huttlin EL (2017), Kroenke J (2014)	4
NEDD8	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Shibata E (2011), Higa LA (2006)	3
DCAF1	5	RBX1	2	pull down	Ahn J (2010)	1
EIF2S2	0	CSNK2A1	15	pull down, far western blotting, far western blotting, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Llorens F (2003), Llorens F (2003), Llorens F (2003), Llorens F (2003), Llorens F (2003), Llorens F (2003), Zhang M (2011)	7
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
DCAF11	2	NFE2L2	1	affinity chromatography technology, enzymatic study	Lo JY (2017), Lo JY (2017)	2
FBXO6	0	COPS7B	0	affinity chromatography technology	Liu B (2012)	1
CUL4B	8	CSN2	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXO6	0	WDR77	2	affinity chromatography technology	Liu B (2012)	1
DDB1	6	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Angers S (2006), Behrends C (2010), Pick E (2007), Pick E (2007), Hrecka K (2007), Hrecka K (2007), Olma MH (2009), Olma MH (2009), Jin J (2006), Wan C (2015)	10
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
CUL4A	2	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Rao F (2014), Rao F (2014), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	13
CUL3	17	FAM98A	3	affinity chromatography technology	Bennett EJ (2010)	1
PMF1	0	COPS7A	0	two hybrid	Wang Y (2002)	1
NEDD8	0	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim TY (2014), Coyaud E (2015)	3
CRBN	2	COPS7A	0	affinity chromatography technology	Kroenke J (2014)	1
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
UBE2M	0	CUL3	17	enzymatic study, pull down	Huang G (2011), Schumacher FR (2015)	2
NEDD8	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
DCAF4	3	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DDIT3	1	CUL1	7	affinity chromatography technology	Huang X (2012)	1
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
RFWD2	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
PMF1	0	NFE2L2	1	two hybrid, pull down	Wang Y (1999), Wang Y (2002)	2
RFWD2	0	DCAF11	2	affinity chromatography technology	Olma MH (2009)	1
MCRS1	1	PRMT5	3	two hybrid	Weimann M (2013)	1
DDA1	1	COPS2	5	affinity chromatography technology	Olma MH (2009)	1
CUL2	3	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	FAM98A	3	affinity chromatography technology	Bennett EJ (2010)	1
FBXW4	0	COPS3	1	affinity chromatography technology	Lockwood WW (2013)	1
GRK5	7	DDB2	1	affinity chromatography technology	Wu Z (2012)	1
FAM98A	3	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Higa LA (2006)	4
FBXO6	0	NEDD8	0	affinity chromatography technology	Liu B (2012)	1
COPS8	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
DTL	0	GPS1	1	affinity chromatography technology	Higa LA (2006)	1
GRK5	7	COPS4	0	affinity chromatography technology	Wu Z (2012)	1
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
COPS7A	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
COPS7A	0	BTBD2	4	affinity chromatography technology	Hein MY (2015)	1
COPS6	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
COPS7A	0	BTBD10	4	affinity chromatography technology	Hein MY (2015)	1
FBXO7	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
CUL2	3	GPS1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001)	2
CUL5	1	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Lee JE (2011), Bennett EJ (2010), Lyapina S (2001), Reitsma JM (2017)	6
CUL3	17	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Huttlin EL (2017)	3
RFWD2	0	CUL2	3	affinity chromatography technology	Olma MH (2009)	1
DCAF8	1	WDR77	2	biochemical	Kristensen AR (2012)	1
PQBP1	1	WDR77	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
DCUN1D1	0	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	DCAF8	1	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017), Boldt K (2016)	7
COPS7A	0	ARHGEF2	4	biochemical	Wan C (2015)	1
COPS2	5	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001), Huttlin EL (2017)	3
CUL4B	8	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Jin J (2006), Hein MY (2015), Wang X (2017)	4
DET1	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
CUL3	17	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	5
COPS7B	0	BTRC	1	affinity chromatography technology	Huang X (2016)	1
CRBN	2	VCP	6	affinity chromatography technology	Nguyen TV (2016)	1
COPS5	0	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
FBXW4	0	COPS7A	0	affinity chromatography technology	Lockwood WW (2013)	1
CUL1	7	COPS8	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Menon S (2008), Bennett EJ (2010), Enchev RI (2012), Reitsma JM (2017)	4
COPS3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Reitsma JM (2017)	4
COPS6	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
COPS2	5	EPB41L1	4	biochemical	Kristensen AR (2012)	1
COPS5	0	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Bhansali M (2014), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	13
COPS5	0	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Groisman R (2006)	5
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
FBXO6	0	ARHGEF2	4	affinity chromatography technology	Liu B (2012)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
COPS4	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
COPS7B	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
PRKD1	7	COPS2	5	enzymatic study	Uhle S (2003)	1
GRK5	7	COPS2	5	affinity chromatography technology	Wu Z (2012)	1
FBXW4	0	COPS6	0	affinity chromatography technology	Lockwood WW (2013)	1
KLHL13	0	COPS2	5	affinity chromatography technology	Sowa ME (2009)	1
COPS7A	0	TOM1L1	1	two hybrid	Stelzl U (2005)	1
COPS6	0	CRBN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Olma MH (2009), Kroenke J (2014)	3
CUL3	17	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furukawa M (2005), Cullinan SB (2004), Cullinan SB (2004)	3
CSNK2B	5	BTRC	1	affinity chromatography technology	Tsuchiya Y (2010)	1
COPS6	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
COPS6	0	FBXL14	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
FBXW11	2	NFE2L2	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014)	2
COPS2	5	COPS7B	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
RAB40AL	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
DDB1	6	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Olma MH (2009)	3
FBXW11	2	DCAF8	1	affinity chromatography technology	Low TY (2014)	1
CSNK2B	5	CSN2	0	enzymatic study	Llorens F (2003)	1
COPS8	2	GPS1	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Stotland A (2012), Sharon M (2009), Sun Y (2002), Kristensen AR (2012), Lingaraju GM (2014), Lyapina S (2001), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
CUL1	7	FAM98A	3	affinity chromatography technology	Bennett EJ (2010)	1
CSNK2A1	15	COPS4	0	affinity chromatography technology	Bhansali M (2014)	1
GRK5	7	USP15	4	affinity chromatography technology	Wu Z (2012)	1
COPS5	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
CUL4B	8	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015), Hein MY (2015)	4
WDR77	2	COPS4	0	biochemical	Kristensen AR (2012)	1
VCP	6	CSNK2B	5	affinity chromatography technology	Yu CC (2013)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	COPS6	0	affinity chromatography technology	Fang L (2015)	1
COPS8	2	WDR77	2	biochemical	Kristensen AR (2012)	1
COPS5	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
KLHL10	1	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	UBE2M	0	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	COPS2	5	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
BTRC	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, bioid	Schweitzer K (2007), Schweitzer K (2007), Coyaud E (2015)	3
APBB3	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
GPS1	1	RBX1	2	affinity chromatography technology	Lyapina S (2001)	1
UBE2M	0	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
KLHL10	1	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
COPS5	0	PSMD12	1	genetic interference	Horlbeck MA (2018)	1
DDA1	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Olma MH (2009), Olma MH (2009)	3
KLHL10	1	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
FBXW4	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
DCUN1D1	0	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
PTGS2	0	COPS5	0	biochemical, affinity chromatography technology, pull down	Neuss H (2007), Neuss H (2007), Neuss H (2007)	3
COPS7B	0	USP15	4	affinity chromatography technology	Huang X (2016)	1
DDB2	1	DDB1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bergametti F (2002), Martinez E (2001), Guerrero-Santoro J (2008), Angers S (2006), Wang H (2006), Kapetanaki MG (2006), Kapetanaki MG (2006), Higa LA (2006), Takedachi A (2010), Fischer ES (2011), Scrima A (2008), Groisman R (2003), Groisman R (2003), Schroefelbauer B (2007), Kulaksiz G (2005), Inoki T (2004), Bontron S (2002), Rapic-Otrin V (2003), Olma MH (2009), Liu W (2000), Jin J (2006), Huttlin EL (2015), Zhao R (2014), Xie X (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Chitale S (2017), Fantini D (2017), Fantini D (2017), Ohtake F (2007)	31
UBE2M	0	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS7A	0	PPBP	2	two hybrid	Stelzl U (2005)	1
BTBD2	4	COPS6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
COPS7A	0	MCRS1	1	affinity chromatography technology	Hein MY (2015)	1
DENR	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
DET1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Pick E (2007), Pick E (2007), Jin J (2006), Huttlin EL (2017)	8
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
SLX4IP	3	CUL1	7	affinity chromatography technology	Svendsen JM (2009)	1
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
DCAF1	5	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCall CM (2008), Olma MH (2009), Hein MY (2015)	3
DET1	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	COPS8	2	affinity chromatography technology	Liu B (2012)	1
APBB3	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	CORO1B	6	affinity chromatography technology	Hein MY (2015)	1
CUL5	1	LRR1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Christmann M (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Scherer PC (2016), Huttlin EL (2017), Boldt K (2016)	15
COPS7B	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
NLRP3	2	COPS7A	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
DCAF11	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
BTRC	1	COPS4	0	affinity chromatography technology	Sowa ME (2009)	1
COPS4	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2017)	2
SLX4IP	3	COPS7A	0	affinity chromatography technology	Svendsen JM (2009)	1
FBXO7	1	NEDD8	0	affinity chromatography technology	Teixeira FR (2016)	1
CUL3	17	KCTD20	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
FBXO7	1	WDR77	2	affinity chromatography technology	Teixeira FR (2016)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Boldt K (2016)	3
FAM98A	3	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Min KW (2005), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	10
RBX1	2	UBE2M	0	pull down, pull down, pull down, pull down, x-ray crystallography, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, enzymatic study, pull down	Okuda H (2001), Yoshida Y (2005), Choi YS (2010), Calabrese MF (2011), Calabrese MF (2011), Kim AY (2008), Scott DC (2014), Markson G (2009), Sufan RI (2006), Huang DT (2009), Morimoto M (2003), Ohki Y (2009), Ohki Y (2009), Wang X (2015)	14
UBE2M	0	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	DCAF8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Jin J (2006), Huttlin EL (2017)	5
RFWD2	0	ERCC8	1	affinity chromatography technology	Olma MH (2009)	1
LRR1	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kamura T (2004), Kamura T (2004)	3
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
COPS3	1	DTL	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Higa LA (2006)	2
COPS7A	0	BTRC	1	affinity chromatography technology	Huang X (2016)	1
GRK5	7	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012)	2
RFWD2	0	CUL1	7	affinity chromatography technology	Olma MH (2009)	1
FBXO6	0	COPS7A	0	affinity chromatography technology	Liu B (2012)	1
DCUN1D1	0	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
DCAF1	5	COPS8	2	affinity chromatography technology, affinity chromatography technology	Hrecka K (2007), Huttlin EL (2017)	2
UBE2M	0	CUL1	7	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Huang G (2011), Huang G (2011), Kim AY (2008), Ponyeam W (2012), Ohki Y (2009), Zhou W (2017), Mo Z (2016)	7
DENR	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS3	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL3	17	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huang X (2016), Huttlin EL (2017)	5
COPS2	5	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS3	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Stotland A (2012), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
CUL4B	8	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
COPS7A	0	COPS2	5	affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
LRR1	1	COPS8	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2017)	2
RFWD2	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
NEDD8	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
CUL1	7	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Reitsma JM (2017)	6
CUL4B	8	DCAF10	2	affinity chromatography technology	Hein MY (2015)	1
CUL4A	2	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009)	7
DDB2	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
CUL3	17	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CRBN	2	COPS2	5	affinity chromatography technology	Kroenke J (2014)	1
APBB3	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	COPS8	2	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
FBXL14	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	CRBN	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Kroenke J (2014)	2
DDB1	6	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Jin J (2006), Jin J (2006), Higa LA (2006), Rossi M (2013), Shibata E (2011), Higa LA (2006), Higa LA (2006)	8
CUL4B	8	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016)	8
DDB1	6	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
COPS3	1	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
CUL1	7	FBXL14	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Reitsma JM (2017)	3
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
RFWD2	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
VCP	6	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bennett EJ (2010), Besten Wd (2012)	3
DENR	2	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
PRMT5	3	WDR77	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, biochemical, biochemical, biochemical, two hybrid, affinity chromatography technology	Friesen WJ (2002), Friesen WJ (2002), Friesen WJ (2002), Friesen WJ (2002), Liu F (2011), Aggarwal P (2010), Aggarwal P (2010), Patel SR (2012), Patel SR (2012), Hosohata K (2003), Hegele A (2012), Hegele A (2012), Antonysamy S (2012), Kristensen AR (2012), Wan C (2015), Lacroix M (2008), Saha K (2016)	17
CRBN	2	DDA1	1	affinity chromatography technology	Kroenke J (2014)	1
DCUN1D1	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	CUL5	1	enzymatic study	Duda DM (2008)	1
DCAF8	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Jin J (2006), Huttlin EL (2017)	2
COPS3	1	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
DDB1	6	GPS1	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Jin J (2006), Emberley ED (2012), Cavadini S (2016)	3
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL4A	2	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010), Jin J (2006), Huttlin EL (2017)	4
BTBD1	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	COPS7B	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	5
CUL1	7	DCAF1	5	affinity chromatography technology	McCall CM (2008)	1
CUL4B	8	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Higa LA (2006), Bennett EJ (2010), Jin J (2006), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	9
CTTN	1	BTRC	1	affinity chromatography technology	Zhao J (2012)	1
FBXL14	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	WDR77	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Wimuttisuk W (2014)	2
PRMT5	3	COPS4	0	biochemical	Kristensen AR (2012)	1
COPS6	0	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
ERCC8	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Olma MH (2009)	3
COPS7A	0	PRMT5	3	biochemical	Kristensen AR (2012)	1
ERCC8	1	COPS2	5	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2
COPS5	0	FBXW11	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	LRR1	1	affinity chromatography technology	Wimuttisuk W (2014)	1
COPS8	2	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
COPS3	1	CSNK2A1	15	far western blotting	Uhle S (2003)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
DCAF4	3	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Hein MY (2015), Huttlin EL (2017)	3
CUL5	1	FAM98A	3	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Olma MH (2009)	5
COPS6	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Enchev RI (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
CUL2	3	SKP2	2	affinity chromatography technology	Kimura Y (2007)	1
DDB1	6	COPS8	2	affinity chromatography technology, pull down	Angers S (2006), Emberley ED (2012)	2
COPS5	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL5	1	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
GRK5	7	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012)	2
EIF2S2	0	CSNK2B	5	pull down, far western blotting, far western blotting, affinity chromatography technology, enzymatic study	Llorens F (2003), Llorens F (2003), Llorens F (2003), Llorens F (2003), Llorens F (2003)	5
CUL1	7	PSMD12	1	biochemical	Wan C (2015)	1
PRKAR2B	1	COPS7A	0	affinity chromatography technology	Hein MY (2015)	1
COPS7A	0	EPB41L1	4	biochemical	Kristensen AR (2012)	1
DDB1	6	COPS4	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Olma MH (2009)	4
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
CUL1	7	CSN1S1	0	affinity chromatography technology	Gastaldello S (2012)	1
NUF2	1	COPS7A	0	affinity chromatography technology	Hein MY (2015)	1
COPS3	1	CRBN	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kroenke J (2014)	2
DCUN1D1	0	CUL2	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Heir P (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Chen K (2016)	13
CUL3	17	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Wimuttisuk W (2014), Maerki S (2009), Huttlin EL (2017)	6
SKP2	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
DCAF8	1	PRMT5	3	biochemical	Kristensen AR (2012)	1
COPS6	0	DCAF10	2	affinity chromatography technology	Olma MH (2009)	1
COPS5	0	CRBN	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kroenke J (2014)	2
PMF1	0	COPS6	0	two hybrid	Stelzl U (2005)	1
CPEB2	7	COPS7A	0	two hybrid	Chen PJ (2012)	1
LRR1	1	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
COPS3	1	DCAF4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
KLHL13	0	COPS4	0	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	CSN1S1	0	pull down, enzymatic study	Benitez MJ (2001), Golsteyn RM (1995)	2
CUL5	1	DCAF1	5	affinity chromatography technology	Bennett EJ (2010)	1
COPS8	2	COPS5	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Olma MH (2009), Asare Y (2013), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	9
CSNK2B	5	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
CUL4B	8	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015), Yang Y (2015)	4
GPS1	1	COPS7A	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015), Hein MY (2015), Huang X (2016)	6
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
DET1	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Hein MY (2015)	6
DDB1	6	CRBN	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Angers S (2006), Ito T (2010), Chamberlain PP (2014), Liu Y (2015), Diaz-Rodriguez E (2016), Xu Q (2016), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Eichner R (2016), Matyskiela ME (2018), Kroenke J (2014)	12
CUL4B	8	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Olma MH (2009)	2
CUL4A	2	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017)	6
PTGS2	0	VCP	6	affinity chromatography technology	Chen SF (2013)	1
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
IKBKB	1	COPS7A	0	two hybrid, affinity chromatography technology	Orel L (2010), Orel L (2010)	2
COPS7A	0	CSNK2A1	15	affinity chromatography technology, far western blotting, enzymatic study	Uhle S (2003), Uhle S (2003), Uhle S (2003)	3
CUL2	3	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Kamura T (2004), Kamura T (2004), Kamura T (2004)	5
VCP	6	CUL5	1	affinity chromatography technology	Yu CC (2013)	1
COPS5	0	RHOBTB1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Fang L (2008), Enchev RI (2010), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Asare Y (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
COPS6	0	COPS7A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	15
APBB3	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Higa LA (2006)	5
DDB2	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Hein MY (2015)	4
RAF1	3	DCAF8	1	two hybrid	Johnson SE (2006)	1
FBXW11	2	COPS7A	0	affinity chromatography technology	Kim TY (2014)	1
CUL3	17	COPS8	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Schumacher FR (2015)	2
COPS6	0	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), McCall CM (2008), Bennett EJ (2010), Olma MH (2009)	4
NEDD8	0	DCAF11	2	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Choi HH (2011), Choi HH (2011)	4
COPS8	2	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
COPS7A	0	TNRC18	8	affinity chromatography technology	Hein MY (2015)	1
DDA1	1	ERCC8	1	affinity chromatography technology	Olma MH (2009)	1
COPS3	1	CSNK2B	5	far western blotting	Uhle S (2003)	1
COPS5	0	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
VCP	6	COPS7A	0	affinity chromatography technology	Yu CC (2013)	1
COPS8	2	COPS6	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
NUF2	1	PMF1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CUL1	7	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Min KW (2005), Min KW (2005), Yang X (2002), Yang X (2002), Huang X (2005), Bennett EJ (2010), Scherer PC (2016), Scherer PC (2016), Reitsma JM (2017)	9
CUL4B	8	PRMT5	3	affinity chromatography technology, affinity chromatography technology	Yang Y (2015), Yang Y (2015)	2
DCUN1D1	0	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Keuss MJ (2016)	2
GPS1	1	COPS7B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Stotland A (2012), Havugimana PC (2012), Huang X (2016), Huttlin EL (2017)	4
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
DDB1	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Jin J (2006), Groisman R (2003), Groisman R (2003), Meulenbroek EM (2012), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Chitale S (2017), Ohtake F (2007)	10
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
APBB3	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Higa LA (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Lu G (2014)	7
COPS4	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CORO1B	6	CTTN	1	biochemical	Havugimana PC (2012)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li T (2006), Norman JA (2006), Huttlin EL (2017)	3
ERCC8	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2
COPS5	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Neuss H (2007), Fang L (2008), Orel L (2010), Uhle S (2003), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	17
DTL	0	RBX1	2	affinity chromatography technology	Shibata E (2011)	1
DCAF1	5	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCall CM (2008), Hrecka K (2007), Olma MH (2009)	3
DCUN1D1	0	KLHL13	0	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
CUL4A	2	DCAF10	2	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010)	2
APBB3	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
DCAF11	2	VCP	6	biochemical	Kristensen AR (2012)	1
COPS6	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009)	5
COPS6	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
COPS6	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Sharon M (2009), Bennett EJ (2010), Lingaraju GM (2014), Huttlin EL (2015), Huttlin EL (2017)	7
USP15	4	BTRC	1	affinity chromatography technology	Greenblatt MB (2016)	1
CUL3	17	BTBD10	4	affinity chromatography technology, two hybrid, affinity chromatography technology	Bennett EJ (2010), Wang J (2011), Huttlin EL (2017)	3
COPS8	2	DTL	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	PRMT5	3	affinity chromatography technology	Liu B (2012)	1
COPS4	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	3
CRBN	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2010), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Kroenke J (2014)	5
DDA1	1	DTL	0	affinity chromatography technology	Olma MH (2009)	1
COPS2	5	BTBD2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS7B	0	COPS7A	0	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
DDA1	1	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
PTGS2	0	COPS3	1	affinity chromatography technology	Neuss H (2007)	1
DDA1	1	DDB2	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Hein MY (2015)	2
UBE2M	0	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei J (2012), Hein MY (2015)	3
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
DCUN1D1	0	UBE2M	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Scott DC (2011), Huang G (2014), Huang G (2014), Keuss MJ (2016), Huttlin EL (2017), Zhou H (2017), Zhou H (2017), Zhou H (2017)	13
COPS5	0	DCAF8	1	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	TOM1L1	1	two hybrid	Vinayagam A (2011)	1
MAPRE1	0	CSN3	1	pull down, imaging technique	Peth A (2007), Peth A (2007)	2
DCAF4	3	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
MAPRE1	0	COPS5	0	pull down	Peth A (2007)	1
VCP	6	PRMT5	3	biochemical	Kristensen AR (2012)	1
CUL4A	2	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Huttlin EL (2017), Lo JY (2017)	10
CUL5	1	BTBD1	2	affinity chromatography technology	Bennett EJ (2010)	1
BTBD1	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Jin J (2006), He YJ (2006), Olma MH (2009), Lu G (2014), Lu G (2014)	6
DCAF4	3	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2M	0	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
DCAF1	5	COPS7B	0	affinity chromatography technology	McCall CM (2008)	1
LRR1	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
COPS7A	0	MAPRE1	0	affinity chromatography technology	Peth A (2007)	1
COPS7A	0	CSN1S1	0	affinity chromatography technology	Luke-Glaser S (2007)	1
KLHL10	1	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
MCRS1	1	CSNK2B	5	affinity chromatography technology	Ewing RM (2007)	1
COPS5	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Bennett EJ (2010)	3
CDC23	3	COPS7A	0	affinity chromatography technology	Hein MY (2015)	1
RFWD2	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
DDB2	1	ERCC8	1	affinity chromatography technology	Groisman R (2003)	1
CUL5	1	DCAF11	2	affinity chromatography technology	Bennett EJ (2010)	1
DCAF8	1	DDB1	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Olma MH (2009), Klein CJ (2014), Jin J (2006), Huttlin EL (2017)	6
COPS4	0	COPS7A	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sharon M (2009), Luke-Glaser S (2007), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016)	13
DDB1	6	BTRC	1	affinity chromatography technology	He YJ (2006)	1
SKP2	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
COPS3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CRBN	2	GPS1	1	affinity chromatography technology	Kroenke J (2014)	1
GPS1	1	COPS4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Stotland A (2012), Tsuge T (2001), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015)	7
DENR	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS7A	0	PSMD12	1	biochemical	Wan C (2015)	1
VCP	6	COPS3	1	affinity chromatography technology	Yu CC (2013)	1
COPS2	5	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Yang X (2002), Choo YY (2011), Bennett EJ (2010), Huttlin EL (2015), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	7
COPS6	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	9
COPS7A	0	DCAF10	2	affinity chromatography technology	Hein MY (2015)	1
SKP2	2	BTRC	1	affinity chromatography technology, pull down, affinity chromatography technology	Wei S (2012), Wei S (2012), Wei S (2012)	3
NEDD8	0	DCAF1	5	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Behrends C (2010), Hrecka K (2007), Hrecka K (2007), Olma MH (2009), Olma MH (2009), Wan C (2015)	6
DET1	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Huttlin EL (2017)	5
DET1	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL5	1	COPS3	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
CUL4A	2	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Hein MY (2015)	7
CUL4B	8	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015), Higa LA (2006)	3
COPS7A	0	EIF2S2	0	affinity chromatography technology	Hein MY (2015)	1
FAM98A	3	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOBTB1	0	CUL5	1	two hybrid	Berthold J (2008)	1
NEDD8	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
RHOBTB1	0	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
UBE2M	0	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
DENR	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
BTRC	1	NFE2L2	1	affinity chromatography technology, bioid	Loveless TB (2015), Coyaud E (2015)	2
DDIT3	1	COPS8	2	affinity chromatography technology, biochemical	Huang X (2012), Huang X (2012)	2
DDB1	6	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Jin J (2006), Huttlin EL (2017)	4
DET1	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	DCAF1	5	affinity chromatography technology	Olma MH (2009)	1
DDB1	6	CORO1B	6	biochemical	Wan C (2015)	1
IKBKB	1	COPS3	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Orel L (2010), Orel L (2010), Asare Y (2013)	3
RAF1	3	COPS7A	0	two hybrid	Johnson SE (2006)	1
CUL5	1	RBX1	2	x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Duda DM (2008), Ohta T (1999), Furukawa M (2002), Tron AE (2012), Tron AE (2012), Yu Y (2004), Huang DT (2009), Wang X (2015), Wang X (2015), Wang X (2015)	10
LRR1	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
COPS5	0	DDB2	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), He YJ (2006), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
FBXO6	0	COPS3	1	affinity chromatography technology	Liu B (2012)	1
DENR	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
BTBD1	2	LRR1	1	affinity chromatography technology	Wimuttisuk W (2014)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL5	1	DDB2	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	DDIT3	1	affinity chromatography technology	Huang X (2012)	1
DDA1	1	COPS8	2	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	CSN1S1	0	affinity chromatography technology	Gastaldello S (2012)	1
DET1	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Olma MH (2009), Pick E (2007), Huttlin EL (2017)	6
LRR1	1	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CUL2	3	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009)	3
COPS2	5	CSNK2A1	15	affinity chromatography technology, enzymatic study	Huang X (2005), Uhle S (2003)	2
DDIT3	1	COPS3	1	biochemical	Huang X (2012)	1
FBXO6	0	COPS4	0	affinity chromatography technology	Liu B (2012)	1
COPS7A	0	DTL	0	affinity chromatography technology	Hein MY (2015)	1
CUL5	1	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
GPS1	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stotland A (2012), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Scherer PC (2016)	5
CUL3	17	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
TOR1AIP1	2	COPS7A	0	affinity chromatography technology	Hein MY (2015)	1
DDB2	1	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
COPS3	1	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
DDB2	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS6	0	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
FBXW4	0	GPS1	1	affinity chromatography technology	Lockwood WW (2013)	1
DET1	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Jin J (2006), Huttlin EL (2017)	2
FBXO7	1	UBE2M	0	enzymatic study	Teixeira FR (2016)	1
FBXL14	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXL14	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
IKBKB	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heissmeyer V (2001), Orel L (2010), Tsuchiya Y (2010), Tsuchiya Y (2010)	4
DCAF1	5	COPS4	0	affinity chromatography technology, affinity chromatography technology	McCall CM (2008), Olma MH (2009)	2
DDB1	6	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Norman JA (2006), Bennett EJ (2010)	3
EPB41L1	4	COPS4	0	biochemical	Kristensen AR (2012)	1
CUL5	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
DDA1	1	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Lu G (2014)	2
VCP	6	ARHGEF2	4	affinity chromatography technology	Yu CC (2013)	1
COPS7A	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CUL2	3	FAM98A	3	affinity chromatography technology	Bennett EJ (2010)	1
DET1	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
FBXW4	0	COPS4	0	affinity chromatography technology	Lockwood WW (2013)	1
COPS3	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
ERCC8	1	COPS8	2	affinity chromatography technology, affinity chromatography technology, biochemical	Groisman R (2003), Groisman R (2003), Groisman R (2006)	3
COPS6	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
COPS5	0	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
KLHL10	1	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS7A	0	RAD17	2	affinity chromatography technology	Hein MY (2015)	1
PTGS2	0	CUL4A	2	affinity chromatography technology	Neuss H (2007)	1
COPS5	0	DDA1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
COPS7A	0	541466	0	affinity chromatography technology	Hein MY (2015)	1
COPS6	0	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009)	4
FBXO6	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
FBXW4	0	COPS8	2	affinity chromatography technology	Lockwood WW (2013)	1
CSNK2B	5	CSN1S1	0	pull down	Benitez MJ (2001)	1
GRK5	7	RBX1	2	affinity chromatography technology	Wu Z (2012)	1
UBE2M	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
KLHL10	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
COPS7A	0	PQBP1	1	affinity chromatography technology	Hein MY (2015)	1
DDB2	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	KLHL13	0	affinity chromatography technology	Hein MY (2015)	1
ERCC8	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Groisman R (2003), Groisman R (2003), Groisman R (2006), Groisman R (2006)	4
GRK5	7	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012), Wu Z (2012)	3
DCAF8	1	COPS4	0	biochemical	Kristensen AR (2012)	1
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
FBXO7	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS7A	0	USP15	4	affinity chromatography technology	Huang X (2016)	1
DCUN1D1	0	RBX1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bommelje CC (2013), Meyer-Schaller N (2009), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016)	9
CUL5	1	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	PRKD1	7	affinity chromatography technology, enzymatic study	Uhle S (2003), Uhle S (2003)	2
CUL3	17	IKBKB	1	affinity chromatography technology	Lee DF (2009)	1
COPS7A	0	CSNK2B	5	far western blotting	Uhle S (2003)	1
PTGS2	0	CUL1	7	affinity chromatography technology	Neuss H (2007)	1
DCAF11	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Hein MY (2015), Huttlin EL (2017)	3
COPS6	0	RHOBTB1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	3
CRBN	2	WDR77	2	affinity chromatography technology	Nguyen TV (2016)	1
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
FBXO6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
DET1	2	RBX1	2	affinity chromatography technology	Wertz IE (2004)	1
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
CUL1	7	CSN2	0	affinity chromatography technology	Boh BK (2011)	1
CUL1	7	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	3
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
APBB3	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	CSN2	0	enzymatic study, enzymatic study	Golsteyn RM (1995), Llorens F (2003)	2
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
COPS8	2	COPS4	0	biochemical, affinity chromatography technology, biochemical, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
DCAF8	1	DCAF11	2	biochemical	Kristensen AR (2012)	1
PTGS2	0	RBX1	2	affinity chromatography technology	Neuss H (2007)	1
EPB41L1	4	COPS5	0	biochemical	Kristensen AR (2012)	1
PQBP1	1	MAPRE1	0	two hybrid	Rolland T (2014)	1
LRR1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
RFWD2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Olma MH (2009)	2
DDA1	1	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	PRMT5	3	biochemical	Kristensen AR (2012)	1
ERCC8	1	GPS1	1	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2