PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHANK1	7	ADGRL2	6	two hybrid	Kreienkamp HJ (2000)	1
SHANK1	7	SHANK3	18	affinity chromatography technology	Mameza MG (2013)	1
SHANK3	18	DLGAP1	6	two hybrid	Boeckers TM (1999)	1
STAT1	1	SHANK1	7	two hybrid	Bandyopadhyay S (2010)	1
DNM2	2	SHANK1	7	two hybrid, affinity chromatography technology, pull down	Okamoto PM (2001), Okamoto PM (2001), Okamoto PM (2001)	3
STAT1	1	SPTAN1	9	two hybrid	Bandyopadhyay S (2010)	1
SHANK1	7	SHANK1	7	x-ray crystallography, two hybrid, affinity chromatography technology	Im YJ (2003), Mameza MG (2013), Mameza MG (2013)	3
ARHGEF7	3	SHANK1	7	two hybrid, affinity chromatography technology, pull down	Park E (2003), Park E (2003), Park E (2003)	3
SHANK1	7	BAIAP2	6	two hybrid, far western blotting, affinity chromatography technology	Soltau M (2002), Soltau M (2002), Soltau M (2002)	3
SHANK3	18	SPTAN1	9	two hybrid	Boeckers TM (2001)	1
ARHGEF7	3	SHANK3	18	two hybrid, affinity chromatography technology	Park E (2003), Park E (2003)	2
SHANK1	7	SHARPIN	1	two hybrid, affinity chromatography technology	Lim S (2001), Lim S (2001)	2
SHANK1	7	DLGAP1	6	x-ray crystallography	Im YJ (2003)	1
SPTAN1	9	SHANK1	7	pull down, affinity chromatography technology	Boeckers TM (2001), Boeckers TM (2001)	2
SHANK1	7	ADGRB2	8	two hybrid	Kreienkamp HJ (2000)	1
SHANK1	7	SSTR2	1	pull down, affinity chromatography technology	Zitzer H (1999), Zitzer H (1999)	2