PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM2	3	NOSIP	2	affinity chromatography technology	Drissi R (2015)	1
ATR	6	NOSIP	2	biochemical	Wan C (2015)	1
NOSIP	2	CUL5	1	affinity chromatography technology	Huttlin EL (2017)	1
NOSIP	2	NOS3	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Schleicher M (2005), Dedio J (2001), Dedio J (2001), Dedio J (2001), Dedio J (2001), Dedio J (2001)	6
EGLN3	0	NOSIP	2	affinity chromatography technology	Rodriguez J (2016)	1
SLC25A21	0	NOSIP	2	affinity chromatography technology	Huttlin EL (2015)	1
EGFR	5	PPP2R2A	0	affinity chromatography technology	Foerster S (2013)	1
MCM2	3	PPP2R1A	8	affinity chromatography technology	Drissi R (2015)	1
CUL3	17	DDX17	2	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	G3BP1	4	affinity chromatography technology	Yao Z (2017)	1
MCM2	3	NEU2	0	affinity chromatography technology	Drissi R (2015)	1
NF1	16	NOSIP	2	biochemical	Wan C (2015)	1
CUL3	17	KPNA1	5	affinity chromatography technology	Bennett EJ (2010)	1
NOSIP	2	PPP2CB	1	affinity chromatography technology	Hoffmeister M (2014)	1
PPP2CB	1	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Fogeron ML (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	15
FOXA1	2	NOSIP	2	affinity chromatography technology	Jozwik KM (2016)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
KPNA1	5	NOSIP	2	pull down	Schleicher M (2005)	1
NOSIP	2	UBE2D3	1	pull down	Hoffmeister M (2014)	1
EGFR	5	PPP2R1A	8	affinity chromatography technology	Foerster S (2013)	1
NOSIP	2	PPP2CA	7	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hoffmeister M (2014), Hoffmeister M (2014), Hoffmeister M (2014), Hoffmeister M (2014)	4
NOSIP	2	TNNC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	HECW2	13	affinity chromatography technology	Yao Z (2017)	1
NEU2	0	NOSIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	PPP2R1A	8	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	NF1	16	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	NOSIP	2	affinity chromatography technology	Yao Z (2017)	1
NOSIP	2	HMCES	1	biochemical	Wan C (2015)	1
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
WWOX	3	DDX17	2	affinity chromatography technology	Abu-Odeh M (2014)	1
ATR	6	MCM2	3	enzymatic study	Cortez D (2004)	1
CUL3	17	G3BP1	4	affinity chromatography technology	Bennett EJ (2010)	1
PPP2R1A	8	PPP2R2A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Havugimana PC (2012), Junttila MR (2007), Fogeron ML (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	17
CUL3	17	PPP2R2A	0	affinity chromatography technology	Bennett EJ (2010)	1
NOSIP	2	EPOR	3	affinity chromatography technology	Friedman AD (2003)	1
FOXA1	2	DDX42	3	affinity chromatography technology	Jozwik KM (2016)	1
EGLN3	0	PPP2CA	7	affinity chromatography technology	Rodriguez J (2016)	1
G3BP1	4	KPNA1	5	affinity chromatography technology	Jain S (2016)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
HECW2	13	NOSIP	2	affinity chromatography technology	Lu L (2013)	1
EGFR	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study	Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996)	7
OTUB1	0	NOSIP	2	affinity chromatography technology	Scholz CC (2016)	1
WWOX	3	NOSIP	2	affinity chromatography technology	Abu-Odeh M (2014)	1
MCM2	3	KPNA1	5	affinity chromatography technology	Drissi R (2015)	1
NOSIP	2	PPP2R1A	8	affinity chromatography technology, pull down, affinity chromatography technology	Hoffmeister M (2014), Hoffmeister M (2014), Hoffmeister M (2014)	3
DDX42	3	NOSIP	2	biochemical	Havugimana PC (2012)	1
EGLN3	0	PPP2R2A	0	affinity chromatography technology	Rodriguez J (2016)	1
POLL	3	NOSIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	PPP2R1A	8	affinity chromatography technology	Rodriguez J (2016)	1
MCM2	3	DDX17	2	affinity chromatography technology	Drissi R (2015)	1
CUL5	1	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	UBE2D3	1	affinity chromatography technology	Drissi R (2015)	1
FAM212B	2	NOSIP	2	affinity chromatography technology	Huttlin EL (2015)	1
G3BP1	4	PPP2R1A	8	affinity chromatography technology	Jain S (2016)	1
UBE2D3	1	POLL	3	enzymatic study	Hoeller D (2007)	1
EGFR	5	ATR	6	affinity chromatography technology	Foerster S (2013)	1
EGLN3	0	OTUB1	0	affinity chromatography technology	Rodriguez J (2016)	1
HECW2	13	UBE2D3	1	pull down	Miyazaki K (2003)	1
G3BP1	4	NOSIP	2	affinity chromatography technology	Jain S (2016)	1
EGLN3	0	SLC25A21	0	affinity chromatography technology	Rodriguez J (2016)	1
NOSIP	2	PTPN11	20	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
HECW2	13	KPNA1	5	affinity chromatography technology	Lu L (2013)	1
EPOR	3	PTPN11	20	affinity chromatography technology, pull down	Tauchi T (1996), Tauchi T (1995)	2
MCM2	3	PPP2R2A	0	affinity chromatography technology	Drissi R (2015)	1
PPP2CB	1	PPP2CA	7	biochemical, affinity chromatography technology	Wan C (2015), St-Denis N (2016)	2
EGLN3	0	KPNA1	5	affinity chromatography technology	Rodriguez J (2016)	1
DDX17	2	NOSIP	2	biochemical	Wan C (2015)	1
PPP2CB	1	PPP2R2A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Glatter T (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	10
NOSIP	2	PPP2R2A	0	affinity chromatography technology, pull down, affinity chromatography technology	Hoffmeister M (2014), Hoffmeister M (2014), Hoffmeister M (2014)	3
PPP2R2A	0	PPP2CA	7	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Kamibayashi C (1992), Kamibayashi C (1992), Goudreault M (2009), Glatter T (2009), Glatter T (2009), Havugimana PC (2012), Wan C (2015), Hein MY (2015), St-Denis N (2016), Bryant JC (1999), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	14
EPOR	3	EGLN3	0	affinity chromatography technology, pull down	Heir P (2016), Heir P (2016)	2
CUL3	17	NOSIP	2	affinity chromatography technology	Bennett EJ (2010)	1
PPP2CA	7	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Kong M (2009), Kong M (2009), Shamay M (2012), Havugimana PC (2012), Junttila MR (2007), Junttila MR (2007), Nazarenko I (2007), Kristensen AR (2012), Fogeron ML (2013), Sablina AA (2010), Lee CW (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Cianfanelli V (2015), St-Denis N (2016), Bryant JC (1999), Shouse GP (2011), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	30