PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ARMT1	0	APIP	0	biochemical	Wan C (2015)	1
ISOC2	0	APIP	0	affinity chromatography technology	Huttlin EL (2017)	1
APIP	0	CFAP206	1	two hybrid	Rolland T (2014)	1
SKP1	0	PSMA1	1	affinity chromatography technology	Hauri S (2016)	1
NIF3L1	0	APIP	0	two hybrid	Venkatesan K (2009)	1
ELAVL1	0	APIP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
APIP	0	HEPHL1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VIM	0	APIP	0	two hybrid	Rual JF (2005)	1
APIP	0	APIP	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	4
APIP	0	WDYHV1	0	two hybrid	Rolland T (2014)	1
IMPDH2	3	APIP	0	two hybrid	Rolland T (2014)	1
APIP	0	LYG2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APIP	0	FASTKD2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NDE1	2	APIP	0	affinity chromatography technology	Hein MY (2015)	1
VIM	0	NIF3L1	0	two hybrid	Rual JF (2005)	1
PSMA1	1	TSC22D4	1	two hybrid	Rual JF (2005)	1
APIP	0	DSG4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APIP	0	LNX1	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
APIP	0	VPS25	1	two hybrid	Rual JF (2005)	1
ELAVL1	0	SDCBP	0	two hybrid	Rolland T (2014)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP1CC	2	APIP	0	two hybrid	Fardilha M (2011)	1
ZBTB25	2	APIP	0	two hybrid	Rolland T (2014)	1
APIP	0	UBA3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	TNPO2	10	affinity chromatography technology	Abdelmohsen K (2009)	1
PSMA1	1	APIP	0	two hybrid	Rolland T (2014)	1
TSC22D4	1	LNX1	7	two hybrid	Rual JF (2005)	1
NIF3L1	0	TSC22D4	1	two hybrid	Rual JF (2005)	1
APIP	0	VSIG8	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SDCBP	0	APIP	0	two hybrid	Rolland T (2014)	1
PSMA1	1	VIM	0	two hybrid	Rual JF (2005)	1
ELAVL1	0	APAF1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
APIP	0	TSC22D4	1	two hybrid	Rolland T (2014)	1
APIP	0	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
APIP	0	PDZD4	0	two hybrid	Rolland T (2014)	1
TNPO2	10	APIP	0	two hybrid	Rolland T (2014)	1
APAF1	8	APIP	0	pull down, affinity chromatography technology, two hybrid	Cho DH (2004), Cho DH (2004), Cho DH (2004)	3
PPP1CC	2	SKP1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
ELAVL1	0	PPP1CC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SKP1	0	APIP	0	two hybrid	Rolland T (2014)	1