PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANGPTL4	2	DNAJB4	0	affinity chromatography technology	Huttlin EL (2017)	1
ANGPTL4	2	ARMC8	1	affinity chromatography technology	Huttlin EL (2017)	1
ANGPTL4	2	WDR47	0	affinity chromatography technology	Huttlin EL (2017)	1
FGFR4	6	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
FBXW7	2	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Thompson BJ (2007), Welcker M (2004), Welcker M (2004), Yada M (2004), Yada M (2004), Yada M (2004), Koch HB (2007), Kim BY (2010), Cho HJ (2010), Popov N (2007), Fujii M (2006), Yumimoto K (2012), Diefenbacher ME (2015), Kourtis N (2015), Kourtis N (2015), Li J (2017), Wang Y (2017), Reiterer V (2017), Chandra S (2013), Chandra S (2013), Chandra S (2013), Chandra S (2013)	22
FBXW7	2	NMT1	4	affinity chromatography technology	Kourtis N (2015)	1
TGFB1	2	NMT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
ANGPTL4	2	PM20D2	0	affinity chromatography technology	Huttlin EL (2017)	1
CDKN2A	1	SMARCA4	19	two hybrid, affinity chromatography technology	Becker TM (2009), Becker TM (2009)	2
ANGPTL4	2	ACTB	8	biochemical	Nishimoto N (2012)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
CDKN2C	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FBXW7	2	AURKA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Otto T (2009), Kwon YW (2012), Kwon YW (2012), Wang Y (2017)	4
SMARCA4	19	ANGPTL4	2	affinity chromatography technology, biochemical	Nishimoto N (2012), Nishimoto N (2012)	2
TGFB1	2	NMT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCA4	19	ACTB	8	affinity chromatography technology, affinity chromatography technology, biochemical	Zhao K (1998), Xu YZ (2011), Nishimoto N (2012)	3
ANGPTL4	2	ITIH2	0	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
AURKA	1	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
ANGPTL4	2	AASDHPPT	0	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	ACTB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ambrosino C (2010), Ambrosino C (2010), Ambrosino C (2010), Tarallo R (2011), Nalvarte I (2010)	5
ANGPTL4	2	NMT1	4	affinity chromatography technology	Huttlin EL (2017)	1
KAT5	1	ESR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Nakajima A (2007), Gaughan L (2001), Jeong KW (2011)	3
CASP8	1	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
MYC	2	ACTB	8	biochemical	Park J (2002)	1
KAT5	1	ACTB	8	affinity chromatography technology, biochemical, affinity chromatography technology	Kim J (2010), Ikura T (2000), Jacquet K (2016)	3
CDKN2A	1	KAT5	1	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
MYC	2	ANGPTL4	2	biochemical	Nishimoto N (2012)	1
MYC	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Ewing RM (2007), Park J (2002), Pal S (2003), Ivanov AA (2017)	4
FBXW7	2	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
KAT5	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Frank SR (2003), Frank SR (2003), Liu T (2007), Liu T (2007), Kim J (2010), Kim J (2010)	6
TGFB1	2	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
ANGPTL4	2	NMT2	2	affinity chromatography technology	Huttlin EL (2017)	1
KAT5	1	ANGPTL4	2	biochemical	Nishimoto N (2012)	1
CDKN2A	1	ACTB	8	pull down	Souza-Rodrigues E (2007)	1
ESR1	0	DNAJB4	0	affinity chromatography technology	Dhamad AE (2016)	1
CDKN2A	1	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
AURKA	1	CDKN2A	1	affinity chromatography technology	Ewing RM (2007)	1
MYC	2	CDKN2C	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2C	0	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
BRMS1	1	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
SMARCA4	19	ESR1	0	two hybrid, pull down	Ichinose H (1997), DiRenzo J (2000)	2