PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBC	7	RLIM	1	affinity chromatography technology	Matsumoto M (2005)	1
UBXN1	0	UNK	3	biochemical	Havugimana PC (2012)	1
EGFR	5	RLIM	1	affinity chromatography technology	Yao Z (2017)	1
HDAC2	1	SS18L1	2	two hybrid	Ravasi T (2010)	1
HDAC2	1	ESR1	0	affinity chromatography technology, affinity chromatography technology	Itoh Y (2007), Tarallo R (2011)	2
SS18L1	2	RLIM	1	two hybrid	Ravasi T (2010)	1
UNK	3	RLIM	1	affinity chromatography technology	Murn J (2015)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
SIAH1	2	UBE2D1	0	two hybrid, two hybrid, pull down, pull down, pull down	Matsuzawa SI (2001), Markson G (2009), Dimitrova YN (2010), Rott R (2008), Liu QY (2008)	5
NR4A1	4	RLIM	1	affinity chromatography technology	Zhou F (2014)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
UBE2D1	0	RLIM	1	two hybrid, pull down, pull down, pull down	Markson G (2009), Gontan C (2012), Her YR (2009), Gao K (2016)	4
STMN1	0	RLIM	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen X (2014), Chen X (2014), Chen X (2014), Chen X (2014), Li C (2015), Li C (2015)	6
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
UBE2D3	1	SIAH1	2	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Liu M (2012), Mei Y (2007), Kim SY (2009)	5
SMURF2	3	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Kim S (2010), Nie J (2010), Lu K (2011), Maspero E (2013), Kristariyanto YA (2015), Mari S (2014), Emanuelli A (2017)	7
UBE2D4	0	RLIM	1	two hybrid	Markson G (2009)	1
LHX3	0	RLIM	1	pull down	Bach I (1999)	1
TOLLIP	3	RLIM	1	affinity chromatography technology	Li S (2011)	1
SIAH1	2	RLIM	1	affinity chromatography technology	Kraemer OH (2008)	1
UBE2E2	1	HDAC2	1	affinity chromatography technology	Kraemer OH (2008)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
UBE2D1	0	UNK	3	biochemical	Havugimana PC (2012)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBXN1	0	RLIM	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
RLIM	1	LNX2	2	two hybrid	Woodsmith J (2012)	1
MDM2	2	UBE2E2	1	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
UBE2D4	0	SIAH1	2	two hybrid	van Wijk SJ (2009)	1
SIN3A	13	RLIM	1	affinity chromatography technology	Bach I (1999)	1
TNFAIP3	3	RLIM	1	two hybrid	Hayes SD (2012)	1
STAT6	1	RLIM	1	two hybrid	Ravasi T (2010)	1
NR4A1	4	AXIN2	1	affinity chromatography technology	Zhou F (2014)	1
LDB1	2	ESR1	0	pull down	Johnsen SA (2009)	1
DNAJB2	0	RLIM	1	affinity chromatography technology	Huttlin EL (2017)	1
BAG6	2	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015)	3
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
RLIM	1	MDM2	2	affinity chromatography technology, pull down, pull down, enzymatic study	Gao K (2016), Gao K (2016), Gao K (2016), Gao K (2016)	4
UBE2D3	1	RLIM	1	two hybrid	Markson G (2009)	1
SIAH1	2	TOLLIP	3	two hybrid	Rolland T (2014)	1
RLIM	1	RLIM	1	affinity chromatography technology	Johnsen SA (2009)	1
UBE2E2	1	SIAH1	2	pull down, affinity chromatography technology, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008), Lee JT (2008)	3
RLIM	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Johnsen SA (2009), Johnsen SA (2009), Johnsen SA (2009)	3
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
UBE2E2	1	RLIM	1	two hybrid, affinity chromatography technology	Markson G (2009), Kraemer OH (2008)	2
EGFR	5	SMURF2	3	affinity chromatography technology, affinity chromatography technology, pull down	Ray D (2011), Ray D (2011), Ray D (2011)	3
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
UNK	3	HDAC2	1	affinity chromatography technology	Murn J (2015)	1
LDB1	2	TOLLIP	3	two hybrid	Rual JF (2005)	1
SMURF2	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
RLIM	1	SNX17	0	two hybrid	Wang J (2011)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
BAG6	2	RLIM	1	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
LDB1	2	RLIM	1	affinity chromatography technology, affinity chromatography technology	Xu Z (2007), Howard PW (2010)	2
RLIM	1	UPF3B	6	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	RPS14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei S (2012), Zhou X (2012), Zhou X (2012), Zhang J (2012), Zhang J (2012), Mukhopadhyay R (2016), Mukhopadhyay R (2016)	7
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
ESR1	0	RPS14	0	affinity chromatography technology	Tarallo R (2011)	1
RLIM	1	PDLIM1	1	affinity chromatography technology, affinity chromatography technology	Johnsen SA (2009), Johnsen SA (2009)	2
RLIM	1	SMURF2	3	imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Huang Y (2011), Huang Y (2011), Huang Y (2011), Huang Y (2011)	4
AXIN2	1	RLIM	1	affinity chromatography technology	Zhou F (2014)	1
LNX2	2	UBE2D2	0	pull down	Nayak D (2015)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
ESR1	0	MDM2	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Liu G (2000), Kinyamu HK (2003), Duong V (2007), Duong V (2007), Duong V (2007), Duong V (2007), Saji S (2001), Saji S (2001)	8
SMURF2	3	UBE2D1	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down	Kim S (2010), Shukla S (2014), Shukla S (2014), Shukla S (2014), Kristariyanto YA (2015)	5
UBE2E1	1	RLIM	1	two hybrid	Markson G (2009)	1
DNAJB2	0	UBC	7	affinity chromatography technology, pull down, two hybrid	Westhoff B (2005), Fenner BJ (2009), Westhoff B (2005)	3
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
RLIM	1	REXO1	6	enzymatic study	Gontan C (2012)	1
UBE2D2	0	RLIM	1	two hybrid	Markson G (2009)	1
HDAC2	1	RLIM	1	affinity chromatography technology	Brandl A (2012)	1
UNK	3	SIN3A	13	affinity chromatography technology	Murn J (2015)	1
PDLIM1	1	ESR1	0	affinity chromatography technology, affinity chromatography technology	Johnsen SA (2009), Johnsen SA (2009)	2
RLIM	1	TERF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Her YR (2009), Her YR (2009), Her YR (2009), Her YR (2009)	4
SIN3A	13	ESR1	0	affinity chromatography technology, affinity chromatography technology	Ellison-Zelski SJ (2009), Zhu P (2006)	2
PDLIM1	1	STMN1	0	biochemical	Wan C (2015)	1
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
RLIM	1	RPS14	0	two hybrid	Wang J (2011)	1
UBE2D2	0	SIAH1	2	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Szargel R (2009), Winter M (2008)	4
HDAC2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Fleischer TC (2003), Fleischer TC (2003), Hakimi MA (2003), Yang L (2003), Laherty CD (1997), Zhang Y (2002), Tong JK (1998), Zhang Y (2005), Nakamura T (2002), Sekhavat A (2007), Zou J (2004), Sun JM (2007), Xue Y (1998), Tsai SC (2002), Brandl A (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hsu DS (2014)	20