PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTK2B	6	FYN	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ganju RK (1997), Katagiri T (2000), Qian D (1997), Qian D (1997), Marie-Cardine A (1999)	5
GP6	0	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
GP6	0	LYN	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki-Inoue K (2002), Suzuki-Inoue K (2002), Locke D (2003), Arthur JF (2011)	4
GP6	0	NCF1	2	affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
GP6	0	CALM1	0	affinity chromatography technology, affinity chromatography technology	Locke D (2003), Arthur JF (2011)	2
TRAF4	1	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
NCF1	2	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
GP6	0	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
TGFB1I1	2	PTK2B	6	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Matsuya M (1998), Wang X (2002), Wang X (2002), Wang X (2002), Wang X (2002), Matsuya M (1998), Matsuya M (1998), Thomas SM (1999)	8
PTK2B	6	LYN	2	affinity chromatography technology	Yamasaki M (2001)	1
GP6	0	FYN	1	pull down	Suzuki-Inoue K (2002)	1
GP6	0	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
NCF1	2	TRAF4	1	affinity chromatography technology, two hybrid	Xu YC (2002), Takeshita F (2005)	2
TRAF4	1	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
GP6	0	FCER1G	0	affinity chromatography technology	Locke D (2003)	1