PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BFAR	0	TMBIM6	1	affinity chromatography technology, affinity chromatography technology	Rong J (2011), Rong J (2011)	2
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
HIP1	4	IFT57	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002), Gervais FG (2002)	3
BCAP31	0	BCL2	0	pull down, affinity chromatography technology	Ng FW (1997), Ng FW (1997)	2
BCL2	0	CASP8	1	affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Poulaki V (2001), Guo Y (2002), Zhu J (2005), Zhu J (2005)	4
HIP1	4	BFAR	0	affinity chromatography technology	Roth W (2003)	1
IFT57	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002)	2
BFAR	0	BCL2	0	affinity chromatography technology, two hybrid	Zhang H (2000), Zhang H (2000)	2
TMBIM6	1	BCL2	0	affinity chromatography technology	Xu Q (1998)	1
BFAR	0	BCL2L1	0	affinity chromatography technology	Zhang H (2000)	1
BCAP31	0	CASP8	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical	Ng FW (1997), Ng FW (1997), Ng FW (1997), Iwasawa R (2011), Chandra D (2004), Breckenridge DG (2002), Breckenridge DG (2002)	7
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
UBE2D1	0	UNK	3	biochemical	Havugimana PC (2012)	1
UBE2N	1	BFAR	0	two hybrid	Markson G (2009)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBE2D3	1	BFAR	0	two hybrid, pull down	Markson G (2009), Rong J (2011)	2
BFAR	0	CASP10	1	affinity chromatography technology	Zhang H (2000)	1
UNK	3	BFAR	0	affinity chromatography technology	Murn J (2015)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
IFT57	1	BFAR	0	affinity chromatography technology	Roth W (2003)	1
UBE2D2	0	BFAR	0	two hybrid, pull down	Markson G (2009), Rong J (2011)	2
UBE2D1	0	BFAR	0	two hybrid	Markson G (2009)	1
NGFR	3	BFAR	0	two hybrid, pull down, affinity chromatography technology	Li H (2012), Li H (2012), Li H (2012)	3
BCAP31	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Ng FW (1997), Ng FW (1997), Mund T (2003)	3
UBE2W	0	BFAR	0	two hybrid	Markson G (2009)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2D4	0	BFAR	0	two hybrid	Markson G (2009)	1
UBE2K	0	BFAR	0	two hybrid	Markson G (2009)	1
BFAR	0	CASP8	1	affinity chromatography technology	Zhang H (2000)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
BFAR	0	UBC	7	enzymatic study	Rong J (2011)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
BCAP31	0	BFAR	0	affinity chromatography technology	Roth W (2003)	1
HIP1	4	CASP8	1	affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002)	2
UBE2U	0	BFAR	0	two hybrid	van Wijk SJ (2009)	1