PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAQ	0	CDK18	3	affinity chromatography technology, pull down	Ichimura T (2013), Meek SE (2004)	2
PPP5C	2	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Zeke T (2005), Silverstein AM (1997), Schuelke JP (2010), Gano JJ (2010), Cliff MJ (2006), Skarra DV (2011), Skarra DV (2011), Horibe T (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015), Woo SH (2009), Woo SH (2009), Woodford MR (2016), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	17
730211	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
CDK15	0	HSP90AB1	2	affinity chromatography technology	Huttlin EL (2015)	1
HSP90AB1	2	EEF2	11	affinity chromatography technology	Falsone SF (2005)	1
FBXW7	2	FKBP5	0	affinity chromatography technology	Kourtis N (2015)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
CTSB	5	BAG6	2	two hybrid	Stelzl U (2005)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
730211	0	HSP90AB1	2	biochemical	Havugimana PC (2012)	1
CDK16	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
CDK16	0	YWHAQ	0	two hybrid	Sladeczek F (1997)	1
TTC29	2	CDK18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	MAGED2	1	biochemical	Kristensen AR (2012)	1
FKBP5	0	APP	1	pull down	Olah J (2011)	1
YWHAE	0	CDK18	3	affinity chromatography technology	Gloeckner CJ (2007)	1
CDK18	3	FKBP5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP5C	2	730211	0	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
YWHAE	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	EEF2	11	affinity chromatography technology	Falsone SF (2005)	1
CDK18	3	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5	0	BAG6	2	two hybrid	Vinayagam A (2011)	1
EIF3I	0	RPL37A	0	biochemical	Wan C (2015)	1
FBXW7	2	MASTL	5	genetic interference	Bailey ML (2015)	1
CDK18	3	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
UBL4A	0	APP	1	pull down	Olah J (2011)	1
GOLGA2	2	CDK18	3	two hybrid	Rolland T (2014)	1
PPP5C	2	YWHAB	1	affinity chromatography technology	Yadav L (2017)	1
CDK18	3	MAGED2	1	affinity chromatography technology	Varjosalo M (2013)	1
CDK18	3	MTUS2	4	two hybrid	Rolland T (2014)	1
CDK18	3	APP	1	pull down	Olah J (2011)	1
CDK18	3	PPP5C	2	affinity chromatography technology	Varjosalo M (2013)	1
UBL4A	0	YWHAE	0	affinity chromatography technology	Xu Y (2012)	1
CDK18	3	RPL37A	0	affinity chromatography technology	Hein MY (2015)	1
CDK18	3	FAAP100	1	affinity chromatography technology	Hein MY (2015)	1
FAAP100	1	APP	1	pull down	Olah J (2011)	1
RAB3IP	0	YWHAE	0	affinity chromatography technology	Boldt K (2016)	1
CDK5	0	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
YWHAB	1	CDK16	0	affinity chromatography technology	Couzens AL (2013)	1
PPP5C	2	YWHAQ	0	affinity chromatography technology	Yadav L (2017)	1
CDK18	3	KRT40	0	two hybrid	Rolland T (2014)	1
CDK15	0	CDC37	0	affinity chromatography technology	Huttlin EL (2015)	1
BAG6	2	STUB1	4	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
CDK18	3	730211	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC37	0	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
KIFC3	3	CDK18	3	two hybrid	Rolland T (2014)	1
YWHAE	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Zuo S (2010)	2
KRT31	0	CDK18	3	two hybrid	Rolland T (2014)	1
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
UBL4A	0	EEF2	11	affinity chromatography technology	Xu Y (2012)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
CDK16	0	PPP2CB	1	affinity chromatography technology	Varjosalo M (2013)	1
CDK18	3	FGR	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	LARP4B	5	affinity chromatography technology	Taipale M (2012)	1
CDK18	3	TRIM27	2	two hybrid	Rolland T (2014)	1
CDK16	0	YWHAE	0	affinity chromatography technology	So J (2015)	1
FBXW7	2	CDK18	3	genetic interference	Bailey ML (2015)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
CDK18	3	MTA2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC37	0	YWHAQ	0	affinity chromatography technology	Li J (2013)	1
PPP5C	2	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Skarra DV (2011), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	9
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
EEF2	11	YWHAQ	0	biochemical	Kristensen AR (2012)	1
CDK18	3	CDK15	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP5C	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Skarra DV (2011), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Yadav L (2017)	7
HSP90AA1	7	CDK15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2015), Huttlin EL (2017)	3
ACKR2	3	APP	1	pull down	Olah J (2011)	1
CCNK	1	LZTS2	4	two hybrid	Rolland T (2014)	1
CDK15	0	730211	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK18	3	CCNK	1	two hybrid	Rual JF (2005)	1
KIFC3	3	TRIM54	1	two hybrid	Rolland T (2014)	1
YWHAE	0	CDC37	0	affinity chromatography technology	Zuo S (2010)	1
UBL4A	0	HSP90AB1	2	affinity chromatography technology	Xu Y (2012)	1
CA4	1	CDK18	3	affinity chromatography technology	Huttlin EL (2017)	1
PPP5C	2	APP	1	pull down	Olah J (2011)	1
CDK18	3	CDC37	0	affinity chromatography technology	Huttlin EL (2015)	1
TRIM27	2	CCDC102B	0	two hybrid	Rolland T (2014)	1
UBL4A	0	HSP90AA1	7	affinity chromatography technology	Xu Y (2012)	1
KIFC3	3	TRIM27	2	two hybrid	Rolland T (2014)	1
CDK16	0	APP	1	pull down	Olah J (2011)	1
CDK18	3	UBL4A	0	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
SFXN2	1	CDK18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAB	1	CDK18	3	affinity chromatography technology	Couzens AL (2013)	1
FKBP5	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
CDK18	3	DNLZ	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPL37A	0	APP	1	pull down	Olah J (2011)	1
CDK18	3	FXR1	0	affinity chromatography technology	Hein MY (2015)	1
CDK18	3	TSGA10	0	two hybrid	Rolland T (2014)	1
HSP90AA1	7	FGR	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
KIFC3	3	APP	1	pull down	Olah J (2011)	1
CDK18	3	PPP2CB	1	affinity chromatography technology	Varjosalo M (2013)	1
CDK15	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
YWHAB	1	APP	1	pull down	Olah J (2011)	1
CDK18	3	GNB4	2	affinity chromatography technology	Varjosalo M (2013)	1
CCDC85B	0	LZTS2	4	two hybrid	Rual JF (2005)	1
CDK18	3	RAB3IP	0	affinity chromatography technology	Boldt K (2016)	1
CDK5	0	CDK18	3	affinity chromatography technology	Varjosalo M (2013)	1
CDK18	3	BAG6	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
CDK18	3	CCDC85B	0	two hybrid	Rual JF (2005)	1
ACKR2	3	CDK18	3	affinity chromatography technology	Huttlin EL (2017)	1
CDK18	3	RBM4	1	affinity chromatography technology	Hein MY (2015)	1
MASTL	5	CDK18	3	affinity chromatography technology	Hein MY (2015)	1
CDK18	3	STUB1	4	affinity chromatography technology	Varjosalo M (2013)	1
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
CCNK	1	CCDC85B	0	two hybrid	Rual JF (2005)	1
CDK18	3	NSRP1	0	affinity chromatography technology	Varjosalo M (2013)	1
TRIM54	1	CCDC102B	0	two hybrid	Rolland T (2014)	1
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
NSRP1	0	APP	1	pull down	Olah J (2011)	1
CDK18	3	PNMA1	0	two hybrid	Rolland T (2014)	1
MAGED2	1	HSP90AB1	2	biochemical	Kristensen AR (2012)	1
CDK18	3	MTR	4	affinity chromatography technology	Varjosalo M (2013)	1
DUSP7	3	CDK18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK18	3	TRIM54	1	two hybrid	Rolland T (2014)	1
UBL4A	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wang Q (2011), Wang Q (2011), Mariappan M (2010), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Mock JY (2015), Mock JY (2015), Kuwabara N (2015), Kuwabara N (2015), Kuwabara N (2015), Wu W (2014), Wu W (2014), Wan C (2015), Hein MY (2015), Rodrigo-Brenni MC (2014), Huttlin EL (2017)	19
CDK18	3	TRPS1	5	affinity chromatography technology	Hein MY (2015)	1
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
CDC37	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
KIFC3	3	CCDC102B	0	two hybrid	Rolland T (2014)	1
CDK18	3	EIF3I	0	affinity chromatography technology	Varjosalo M (2013)	1
CDK5	0	CDK16	0	enzymatic study	Cheng K (2002)	1
CDK18	3	LARP4B	5	affinity chromatography technology	Varjosalo M (2013)	1
CDK16	0	RAB3IP	0	affinity chromatography technology	Boldt K (2016)	1
CDK18	3	CCDC102B	0	two hybrid	Rolland T (2014)	1
MAGED2	1	FKBP5	0	biochemical	Kristensen AR (2012)	1
BAG6	2	TRIM27	2	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
CDK18	3	CCNDBP1	0	two hybrid	Rolland T (2014)	1
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
CDK18	3	EEF2	11	affinity chromatography technology	Varjosalo M (2013)	1
CDK5	0	STUB1	4	affinity chromatography technology	Kim C (2016)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
YWHAB	1	HSP90AB1	2	affinity chromatography technology	Jin J (2004)	1
RAB3IP	0	KRT40	0	two hybrid	Rolland T (2014)	1
CDK18	3	MIPOL1	1	two hybrid	Rolland T (2014)	1
KIFC3	3	KRT31	0	two hybrid	Rolland T (2014)	1
KIFC3	3	LZTS2	4	two hybrid	Rolland T (2014)	1
CDK18	3	CTSB	5	affinity chromatography technology	Varjosalo M (2013)	1
HSP90AB1	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
EEF2	11	RBM4	1	biochemical	Havugimana PC (2012)	1
CTSB	5	APP	1	pull down	Olah J (2011)	1
FUBP3	0	APP	1	pull down	Olah J (2011)	1
CDK18	3	FUBP3	0	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	CDK18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2015), Huttlin EL (2017)	3
RAB3IP	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
UBL4A	0	RPL37A	0	affinity chromatography technology	Xu Y (2012)	1
CDK18	3	P3H1	2	affinity chromatography technology	Hein MY (2015)	1
CDK18	3	LZTS2	4	two hybrid	Rolland T (2014)	1
KIFC3	3	KRT40	0	two hybrid	Rolland T (2014)	1
CDK5	0	HSP90AB1	2	affinity chromatography technology	Varjosalo M (2013)	1
CDK16	0	CDK18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2