PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UNK	3	FAM13B	2	affinity chromatography technology	Murn J (2015)	1
ELAVL1	0	YWHAG	5	affinity chromatography technology	Abdelmohsen K (2009)	1
YWHAG	5	FAM13B	2	two hybrid	Bandyopadhyay S (2010)	1
ELAVL1	0	FAM13B	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UNK	3	YWHAG	5	affinity chromatography technology	Murn J (2015)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
YWHAZ	1	FAM13B	2	two hybrid	Bandyopadhyay S (2010)	1
UNK	3	YWHAE	0	affinity chromatography technology	Murn J (2015)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
SAMHD1	3	FAM13B	2	two hybrid	Morrissey C (2015)	1
YWHAE	0	FAM13B	2	two hybrid	Bandyopadhyay S (2010)	1
UNK	3	YWHAZ	1	affinity chromatography technology	Murn J (2015)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4