PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	Symbol B	Interaction detection method	Publication	Evidence
ELAVL1	TP53	affinity chromatography technology	Galban S (2003)	1
TRIP13	RBPMS	two hybrid	Rual JF (2005)	1
COPS5	PLAC8	two hybrid	Wang J (2008)	1
COPS5	ELAVL1	affinity chromatography technology	Bennett EJ (2010)	1
TP53	PLAC8	genetic interference	Xie L (2013)	1
ELAVL1	PLAC8	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	TP53	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
TRIP13	PLAC8	two hybrid	Rual JF (2005)	1
RBPMS	PLAC8	two hybrid	Rolland T (2014)	1