Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
TAOK3	51347	CHEMBL524266	CHEMBL524266	inhibitor	GuideToPharmacologyInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TAOK3	rs795484	TT	morphine	"dosage","efficacy"	yes	Association described as 'nominally significant' in the paper and was only seen in European Caucasian patients. Please note that alleles have been complemented to the positive strand.	Genotype TT is associated with increased dose of morphine in children with Pain, Postoperative as compared to genotypes CC + CT.	24909733	1450376100
TAOK3	rs1277441	GG	morphine	"dosage","efficacy"	yes	Association described as 'nominally significant' in the paper and was only seen in European Caucasian patients. Please note that alleles have been complemented to the positive strand.	Genotype GG is associated with increased dose of morphine in children with Pain, Postoperative as compared to genotypes AA + AG.	24909733	1450376124
TAOK3	rs795484	CT + TT	opioids	dosage	yes	Patients with the CT or TT genotypes were significantly more likely to have an overall morphine-equivalent daily dose of 800mg or higher than patients with the CC genotype. Please note that alleles have been complemented to the positive strand and that rs1277441 was found to be in linkage disequilibrium with rs795484.	Genotypes CT + TT are associated with increased dose of opioids in people with Neoplasms and Pain as compared to genotype CC.	30031856	1450929002
TAOK3	rs1277441	AG + GG	opioids	dosage	yes	Patients with the AG or GG genotypes were significantly more likely to have an overall morphine-equivalent daily dose of 800mg or higher than patients with the AA genotype. Please note that alleles have been complemented to the positive strand and that rs1277441 was found to be in linkage disequilibrium with rs795484.	Genotypes AG + GG are associated with increased dose of opioids in people with Neoplasms and Pain as compared to genotype AA.	30031856	1450928977
TAOK3	rs795484	TT	opioids	dosage	yes	Patients with the TT genotypes were significantly more likely to have been prescribed multiple opioids than patients with the CC or CT genotypes. There was also a non-significant trend for higher use of methadone in TT patients (the authors note that methadone is typically prescribed when the patient fails to respond to first- or second-line opioids). Please note that alleles have been complemented to the positive strand and that rs1277441 was found to be in linkage disequilibrium with rs795484.	Genotype TT is associated with decreased response to opioids in people with Neoplasms and Pain as compared to genotypes CC + CT.	30031856	1450928995
TAOK3	rs1277441	GG	opioids	dosage	no	Patients with the GG genotypes were significantly more likely to have been prescribed multiple opioids than patients with the AA or AG genotypes. There was also a non-significant trend for higher use of methadone in GG patients (the authors note that methadone is typically prescribed when the patient fails to respond to first- or second-line opioids). Please note that alleles have been complemented to the positive strand and that rs1277441 was found to be in linkage disequilibrium with rs795484.	Genotype GG is associated with decreased response to opioids in people with Neoplasms and Pain as compared to genotypes AA + AG.	30031856	1450928984