PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NOLC1	2	POLD1	5	affinity chromatography technology	Boldt K (2016)	1
POLK	0	PCGF5	1	affinity chromatography technology	Hein MY (2015)	1
KCTD17	0	KCTD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MSH2	4	REV1	1	affinity chromatography technology, affinity chromatography technology	Lv L (2013), Lv L (2013)	2
POLK	0	RPA1	0	affinity chromatography technology, imaging technique	Ogi T (2010), Ogi T (2010)	2
POLK	0	MAK16	1	affinity chromatography technology	Hein MY (2015)	1
PARVG	1	POLK	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MSH6	2	H3F3A	1	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	XPO7	5	affinity chromatography technology	Fei T (2017)	1
RPA1	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
POLK	0	MSH2	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Lv L (2013), Lv L (2013), Lv L (2013)	3
POLK	0	MCM4	3	affinity chromatography technology	Lv L (2013)	1
POLK	0	TIA1	0	affinity chromatography technology	Hein MY (2015)	1
POLK	0	UBE2V2	0	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	MSH2	4	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
CD2BP2	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
POLK	0	RBM4	1	affinity chromatography technology	Hein MY (2015)	1
POLK	0	WRN	6	pull down	Maddukuri L (2014)	1
POLK	0	CD99L2	2	affinity chromatography technology	Hein MY (2015)	1
POLK	0	H3F3A	1	affinity chromatography technology	Hein MY (2015)	1
MSH2	4	MSH6	2	biochemical, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, biochemical, affinity chromatography technology, imaging technique	Wang Y (2000), Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Matton N (2000), Matton N (2000), Yang Q (2004), Havugimana PC (2012), Gradia S (1997), Owen BA (2009), Wan C (2015), Hein MY (2015), Chen TC (2014)	15
PCNA	0	REV1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Pozo FM (2011), Pozo FM (2011), Qin Z (2013), Shim HS (2015)	4
POLK	0	RAD18	3	affinity chromatography technology, affinity chromatography technology, pull down	Bi X (2006), Lin JR (2011), Lin JR (2011)	3
RPA1	0	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
RPA1	0	7515	0	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
RAD51	3	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, pull down, far western blotting	Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006)	5
PCNA	0	MCM4	3	affinity chromatography technology	Han J (2014)	1
RAD51	3	MSH6	2	affinity chromatography technology	Yang Q (2004)	1
POLK	0	KCTD5	0	affinity chromatography technology	Hein MY (2015)	1
PCNA	0	POLD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Naryzhny SN (2005), Naryzhny SN (2004), Ogi T (2010), Shikata K (2001), Shikata K (2001), Xie B (2002), Li H (2006), Park JM (2014), Han J (2014), Hein MY (2015)	11
RAD51	3	RAD18	3	affinity chromatography technology, pull down, affinity chromatography technology	Huang J (2009), Huang J (2009), Chen X (2016)	3
POLK	0	MSH6	2	affinity chromatography technology	Lv L (2013)	1
POLK	0	ZCCHC6	2	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	MCM6	5	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
POLK	0	RPAP1	5	affinity chromatography technology	Hein MY (2015)	1
POLK	0	FIP1L1	2	affinity chromatography technology	Hein MY (2015)	1
POLK	0	SRA1	0	affinity chromatography technology	Hein MY (2015)	1
PCNA	0	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Rodriguez-Lopez AM (2003), Rodriguez-Lopez AM (2003), Huang S (2000), Kobayashi J (2010), Baynton K (2003)	5
PCNA	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Ogi T (2010), Takasaki Y (2001), Gong Z (2011), Miccoli L (2005), Han J (2014)	6
RPA1	0	RBM4	1	affinity chromatography technology	Marechal A (2014)	1
POLK	0	KLF16	1	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	POLK	0	affinity chromatography technology	Fei T (2017)	1
POLD1	5	RPA1	0	biochemical	Havugimana PC (2012)	1
POLK	0	POLD1	5	affinity chromatography technology	Ogi T (2010)	1
HNRNPL	3	RBM4	1	affinity chromatography technology	Fei T (2017)	1
POLK	0	MCM6	5	affinity chromatography technology	Lv L (2013)	1
DTD1	0	POLK	0	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	RAD51	3	affinity chromatography technology, imaging technique	Chen X (2016), Sato K (2016)	2
7515	0	POLK	0	affinity chromatography technology, affinity chromatography technology	Ogi T (2010), Ogi T (2010)	2
POLK	0	STAT6	1	affinity chromatography technology	Hein MY (2015)	1
MSH6	2	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, biochemical, affinity chromatography technology	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Jascur T (2011), Schoepf B (2012), Havugimana PC (2012), Dzantiev L (2004), Han J (2014), Wan C (2015), Hein MY (2015)	11
RAD51	3	RPA1	0	pull down, two hybrid	Sugiyama T (2002), Du Y (2009)	2
PCNA	0	POLK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bi X (2006), Ogi T (2010), Ogi T (2010), Jones MJ (2011), Boehm EM (2016)	5
PCNA	0	7515	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, fluorescent resonance energy transfe, affinity chromatography technology	Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Ogi T (2010)	6
RBM4	1	7515	0	biochemical	Havugimana PC (2012)	1
RAD51	3	MSH2	4	affinity chromatography technology	Yang Q (2004)	1
PCNA	0	TRAIP	0	affinity chromatography technology, pull down, x-ray crystallography	Hoffmann S (2016), Hoffmann S (2016), Hoffmann S (2016)	3
RAD18	3	PCNA	0	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Song IY (2010), Inagaki A (2011), Kobayashi J (2010), Masuda Y (2010), Watanabe K (2004), Watanabe K (2004), Watanabe K (2004), Notenboom V (2007), Notenboom V (2007), Wong RP (2011), Masuda Y (2012), Unk I (2006), Tomida J (2008), Durando M (2013), Han J (2014), Han J (2014), Han J (2014), Masuda Y (2012), Masuda Y (2015), Guan J (2017)	20
KCTD17	0	POLK	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLK	0	BHLHE41	0	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	MCM4	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
TRAIP	0	POLK	0	two hybrid	Wallace HA (2014)	1
PCNA	0	MSH2	4	affinity chromatography technology, far western blotting	Ohta S (2002), Dzantiev L (2004)	2
REV1	1	POLK	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down	Ohashi E (2004), Ohashi E (2004), Ohashi E (2004), Ohashi E (2004), Tissier A (2004), Ohashi E (2009), Ohashi E (2009), Boehm EM (2016), Pustovalova Y (2016)	9
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
7515	0	POLD1	5	affinity chromatography technology	Ogi T (2010)	1
POLK	0	APOL2	0	affinity chromatography technology	Hein MY (2015)	1
POLK	0	RAD51	3	affinity chromatography technology	Hein MY (2015)	1
POLK	0	XPO7	5	affinity chromatography technology	Lv L (2013)	1
POLK	0	PLXNA3	5	affinity chromatography technology	Hein MY (2015)	1
POLK	0	SBSN	1	affinity chromatography technology	Hein MY (2015)	1
POLK	0	CD2BP2	0	affinity chromatography technology	Hein MY (2015)	1
POLK	0	SYNPO2	1	affinity chromatography technology	Hein MY (2015)	1
POLK	0	NOLC1	2	affinity chromatography technology	Hein MY (2015)	1
SPART	0	POLK	0	affinity chromatography technology	Huttlin EL (2017)	1
POLK	0	PIAS1	4	affinity chromatography technology	Hein MY (2015)	1