PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DNAAF2	2	HPCAL4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC22D3	1	HPCAL4	0	two hybrid	Rual JF (2005)	1
HPCAL4	0	FAM131C	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CYP1A1	1	HPCAL4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXL16	4	HPCAL4	0	affinity chromatography technology	Tan MK (2013)	1
DGUOK	1	HPCAL4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HPCAL4	0	TTC12	2	two hybrid	Rolland T (2014)	1
LITAF	0	HPCAL4	0	affinity chromatography technology	Huttlin EL (2017)	1
HPCAL4	0	DTX2	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NUFIP1	0	HPCAL4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE3A	4	HPCAL4	0	two hybrid	Vinayagam A (2011)	1