PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
MYC	2	POLH	1	genetic interference	Toyoshima M (2012)	1
FANCI	1	REV1	1	affinity chromatography technology	Yang Y (2015)	1
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
CLK1	1	REV1	1	enzymatic study	Lipp JJ (2015)	1
MAD2L2	0	POLDIP2	1	two hybrid	Tissier A (2010)	1
MSH2	4	REV1	1	affinity chromatography technology, affinity chromatography technology	Lv L (2013), Lv L (2013)	2
FHL2	0	REV1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Wixler V (2000), Wixler V (2000), Wixler V (2000)	3
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
MYC	2	REV1	1	genetic interference	Toyoshima M (2012)	1
HSP90AA1	7	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson N (2013), Johnson N (2013), Ertych N (2016)	3
REV1	1	CDC27	2	affinity chromatography technology	Chun AC (2013)	1
REV1	1	REV1	1	two hybrid	Ohashi E (2009)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
BRCA1	7	RELA	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Benezra M (2003), Benezra M (2003), Benezra M (2003), Volcic M (2012)	4
FANCD2	3	BRCA1	7	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reuter TY (2003), Vandenberg CJ (2003), Garcia-Higuera I (2001), Garcia-Higuera I (2001), Loke J (2015)	5
POLK	0	MSH2	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Lv L (2013), Lv L (2013), Lv L (2013)	3
UBC	7	FHL2	0	affinity chromatography technology	Matsumoto M (2005)	1
POLH	1	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
TP53	0	POLD3	0	genetic interference	Xie L (2013)	1
REV1	1	HSP90AB1	2	affinity chromatography technology	Pozo FM (2011)	1
RELA	1	UBC	7	affinity chromatography technology	Schweitzer K (2015)	1
POLI	5	REV1	1	two hybrid, two hybrid, pull down	Ohashi E (2004), Ohashi E (2009), Ohashi E (2009)	3
FAAP20	1	UBC	7	pull down, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, pull down	Yan Z (2012), Toma A (2015), Toma A (2015), Ali AM (2012), Wojtaszek JL (2014), Wojtaszek JL (2014), Lim K (2015)	7
POLD3	0	MAD2L2	0	affinity chromatography technology	Kim MS (2013)	1
PCNA	0	REV1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Pozo FM (2011), Pozo FM (2011), Qin Z (2013), Shim HS (2015)	4
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
TSC22D2	2	REV1	1	two hybrid	Li Q (2016)	1
TP53	0	HSP90AB1	2	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
TP53	0	POLI	5	affinity chromatography technology, imaging technique	Hampp S (2016), Hampp S (2016)	2
POLI	5	UBC	7	two hybrid, two hybrid, far western blotting, x-ray crystallography, pull down, far western blotting	Plosky BS (2006), Plosky BS (2006), McIntyre J (2012), Bomar MG (2010), Plosky BS (2006), McIntyre J (2012)	6
REV1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Pozo FM (2011), Pozo FM (2011)	2
BRCA1	7	FHL2	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Yan J (2003), Yan J (2003), Yan JH (2003), Yan JH (2003), Yan JH (2003), Yan J (2003), Wang J (2011), Hill SJ (2014)	8
REV1	1	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
BRCA1	7	PIAS4	5	imaging technique, enzymatic study, imaging technique	Galanty Y (2009), Morris JR (2009), Morris JR (2009)	3
MYC	2	FANCI	1	affinity chromatography technology	Ewing RM (2007)	1
BRCA1	7	MSH2	4	two hybrid, pull down, biochemical, affinity chromatography technology, genetic interference	Wang Q (2001), Wang Q (2001), Wang Y (2000), Wada-Hiraike O (2005), Peng M (2014)	5
PIAS4	5	FANCI	1	affinity chromatography technology	Gibbs-Seymour I (2015)	1
PIAS4	5	FANCD2	3	affinity chromatography technology	Gibbs-Seymour I (2015)	1
PCNA	0	FANCD2	3	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Howlett NG (2009), Howlett NG (2009), Howlett NG (2009), Chen X (2016)	4
POLH	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Sekimoto T (2010), Sekimoto T (2010), Sekimoto T (2010)	3
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
FANCI	1	FANCD2	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid	Yuan F (2009), Ishiai M (2008), Sims AE (2007), Rego MA (2012), Longerich S (2014), Polito D (2014), Wang D (2016), Oka Y (2015), Oka Y (2015), Oka Y (2015), Oka Y (2015), Unno J (2014), Long DT (2011), Sato K (2014), Sato K (2014), Takahashi D (2014), Gwon GH (2014), Lossaint G (2013), Siddiqui MQ (2017), Inano S (2017)	20
POLD3	0	PCNA	0	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, unspecified method, two hybrid, far western blotting, fluorescent resonance energy transfe, affinity chromatography technology	Ducoux M (2001), Ohta S (2002), Pohler JR (2005), Shikata K (2001), Shikata K (2001), Bruning JB (2004), Plosky BS (2006), Li H (2006), Nicolae CM (2014), Hein MY (2015)	10
MAD2L2	0	REV3L	8	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Murakumo Y (2000), Murakumo Y (2000), Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Hashimoto K (2012), Sharma S (2012), Sharma S (2012), Hara K (2010), Hara K (2010), Hara K (2010), Hara K (2009), Kikuchi S (2012)	13
PCNA	0	POLK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bi X (2006), Ogi T (2010), Ogi T (2010), Jones MJ (2011), Boehm EM (2016)	5
FANCD2	3	REV1	1	affinity chromatography technology	Yang Y (2015)	1
TP53	0	POLDIP2	1	affinity chromatography technology	Fogeron ML (2013)	1
PCNA	0	POLDIP2	1	two hybrid, pull down, affinity chromatography technology	Liu L (2003), Liu L (2003), Liu L (2003)	3
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
UBC	7	HSP90AB1	2	affinity chromatography technology	Bish RA (2007)	1
REV1	1	TP53	0	affinity chromatography technology	Shim HS (2015)	1
MYC	2	RELA	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Chapman NR (2002), Covic M (2005), Ivanov AA (2017)	3
MSH2	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zink D (2002), Zink D (2002), Yang Q (2004)	3
MYC	2	FANCD2	3	affinity chromatography technology, imaging technique	Koch HB (2007), Panneerselvam J (2014)	2
MYC	2	MSH2	4	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Mac Partlin M (2003), Koch HB (2007), Ivanov AA (2017)	3
MAD2L2	0	REV1	1	two hybrid, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, pull down	Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Pozo FM (2011), Ohashi E (2004), Hashimoto K (2012), Sharma S (2012), Hara K (2010), Masuda Y (2003), Tissier A (2004), Chun AC (2013), Pustovalova Y (2012), Kikuchi S (2012), Kikuchi S (2012)	15
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
UBC	7	POLH	1	pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Bienko M (2005), Plosky BS (2006), Sekimoto T (2010), Bienko M (2005), Plosky BS (2006), Ahmed-Seghir S (2015)	6
MYC	2	FHL2	0	affinity chromatography technology	Agrawal P (2010)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
POLH	1	PCNA	0	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology	Haracska L (2001), Haracska L (2001), Kannouche PL (2004), Bienko M (2010), Bienko M (2010), Bienko M (2010), Bienko M (2010), Jung YS (2011), Zlatanou A (2011), Plosky BS (2006), Vidal AE (2004), Sekimoto T (2010), Hibbert RG (2012), Mosbech A (2012), Durando M (2013), Qin Z (2013), Fu D (2013), Fu D (2013), Sekimoto T (2010), Sekimoto T (2010), Sekimoto T (2010), Ahmed-Seghir S (2015), Inoue A (2014), Hedglin M (2016), Hedglin M (2016), Dai X (2016), Guan J (2017)	27
PCNA	0	MSH2	4	affinity chromatography technology, far western blotting	Ohta S (2002), Dzantiev L (2004)	2
REV1	1	POLK	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down	Ohashi E (2004), Ohashi E (2004), Ohashi E (2004), Ohashi E (2004), Tissier A (2004), Ohashi E (2009), Ohashi E (2009), Boehm EM (2016), Pustovalova Y (2016)	9
UBC	7	REV1	1	pull down	Pozo FM (2011)	1
FAAP20	1	REV1	1	affinity chromatography technology, pull down	Kim H (2012), Lim K (2015)	2
RELA	1	REV1	1	affinity chromatography technology	Veena MS (2014)	1
FANCI	1	FAAP20	1	affinity chromatography technology	Hein MY (2015)	1
REV3L	8	REV1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sharma S (2012), Sharma S (2012), Hara K (2010)	3
POLI	5	POLH	1	two hybrid, far western blotting, two hybrid, far western blotting, affinity chromatography technology	Kannouche P (2003), Kannouche P (2003), McIntyre J (2012), McIntyre J (2012), McIntyre J (2012)	5
CLK1	1	PIAS4	5	two hybrid	Goehler H (2004)	1
CDC27	2	MAD2L2	0	affinity chromatography technology	Uzunova K (2012)	1
REV1	1	PIAS4	5	affinity chromatography technology	Shim HS (2015)	1
CDC27	2	PCNA	0	affinity chromatography technology	Williamson A (2011)	1
POLD3	0	REV1	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Kim MS (2013), Kim MS (2013), Pustovalova Y (2016), Pustovalova Y (2016)	4
POLH	1	REV1	1	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, pull down, two hybrid, pull down, pull down	Yuasa MS (2006), Yuasa MS (2006), Pozo FM (2011), Ohashi E (2004), Ohashi E (2004), Pozhidaeva A (2012), Pozhidaeva A (2012), Tissier A (2004), Tissier A (2004), Ohashi E (2009), Ohashi E (2009), Pustovalova Y (2012)	12
FANCD2	3	MSH2	4	affinity chromatography technology, genetic interference	Williams SA (2011), Peng M (2014)	2
REV1	1	POLDIP2	1	two hybrid	Tissier A (2010)	1
FANCD2	3	POLH	1	affinity chromatography technology, affinity chromatography technology, biochemical	Fu D (2013), Fu D (2013), Fu D (2013)	3
POLI	5	PCNA	0	two hybrid, x-ray crystallography, two hybrid, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, pull down	Plosky BS (2006), Hishiki A (2008), Vidal AE (2004), Vidal AE (2004), Haracska L (2001), McIntyre J (2012), McIntyre J (2012), Boehm EM (2016)	8
BRCA1	7	HSP90AB1	2	affinity chromatography technology	Ertych N (2016)	1