PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SPTAN1	9	TES	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rotter B (2005), Rotter B (2005), Rotter B (2005), Sala S (2017)	4
PFN2	0	VASP	0	pull down, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Reinhard M (1995), Reinhard M (1995), Harbeck B (2000), Harbeck B (2000), Huttlin EL (2017)	5
EVL	4	TRAF7	11	affinity chromatography technology	Huttlin EL (2017)	1
EVL	4	ETFRF1	0	affinity chromatography technology	Huttlin EL (2017)	1
ZDHHC17	1	WASF2	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
EVL	4	TACC3	1	affinity chromatography technology	Huttlin EL (2017)	1
PFN2	0	HTT	14	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
EVL	4	EXD2	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	ZYX	2	affinity chromatography technology	Kirli K (2015)	1
RAD21	3	RPL23	0	affinity chromatography technology	Panigrahi AK (2011)	1
POT1	2	EVL	4	two hybrid	Lee OH (2011)	1
U2AF2	7	SPTAN1	9	affinity chromatography technology	Whisenant TC (2015)	1
TACC3	1	ENAH	0	affinity chromatography technology	Hein MY (2015)	1
BAG3	4	EVL	4	affinity chromatography technology	Chen Y (2013)	1
ENAH	0	EVL	4	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ENAH	0	ZYX	2	two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology	Tani K (2003), Drees B (2000), Drees B (2000), Huttlin EL (2017)	4
EVL	4	RPL23	0	affinity chromatography technology	Huttlin EL (2017)	1
XIRP1	9	EVL	4	two hybrid	van der Ven PF (2006)	1
ZYX	2	EVL	4	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	FBLIM1	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	ENAH	0	affinity chromatography technology	Kirli K (2015)	1
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
TERF1	1	EVL	4	two hybrid	Lee OH (2011)	1
TES	1	ZYX	2	pull down, affinity chromatography technology, affinity chromatography technology	Garvalov BK (2003), Huttlin EL (2017), Sala S (2017)	3
ABL1	9	SPTAN1	9	pull down, two hybrid	Ziemnicka-Kotula D (1998), Ziemnicka-Kotula D (1998)	2
XPO1	8	ABL1	9	unspecified method, unspecified method	Xu D (2012), Hantschel O (2005)	2
VASP	0	ENAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
SRC	2	EVL	4	pull down	Lambrechts A (2000)	1
PFN2	0	ENAH	0	affinity chromatography technology	Huttlin EL (2017)	1
TERF1	1	PFN2	0	two hybrid	Stelzl U (2005)	1
XIRP1	9	VASP	0	two hybrid, far western blotting, far western blotting	van der Ven PF (2006), van der Ven PF (2006), van der Ven PF (2006)	3
APBB1	3	ENAH	0	pull down, x-ray crystallography, unspecified method	Ingham RJ (2005), Meiyappan M (2007), Meiyappan M (2007)	3
VASP	0	TRIM9	3	two hybrid	Rual JF (2005)	1
PRPF40A	5	U2AF2	7	pull down, pull down	Ingham RJ (2005), Lin KT (2004)	2
PFN2	0	EVL	4	pull down	Lambrechts A (2000)	1
EVL	4	ENDOG	2	affinity chromatography technology	Huttlin EL (2017)	1
ABI3	1	ENAH	0	affinity chromatography technology, pull down	Hirao N (2006), Hirao N (2006)	2
ABI3	1	EVL	4	two hybrid	Rolland T (2014)	1
ABL1	9	EVL	4	pull down	Lambrechts A (2000)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
APBB1	3	U2AF2	7	pull down	Ingham RJ (2005)	1
HTT	14	EVL	4	two hybrid	Suter B (2013)	1
RAD21	3	EVL	4	affinity chromatography technology	Panigrahi AK (2011)	1
EVL	4	LETMD1	1	affinity chromatography technology	Huttlin EL (2017)	1
TACC3	1	VASP	0	affinity chromatography technology	Hein MY (2015)	1
VASP	0	ABI3	1	two hybrid	Rolland T (2014)	1
VASP	0	ZYX	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harbeck B (2000), Harbeck B (2000), Drees B (2000), Huttlin EL (2017)	4
U2AF2	7	ZYX	2	affinity chromatography technology	Whisenant TC (2015)	1
POT1	2	SPTAN1	9	affinity chromatography technology	Giannone RJ (2010)	1
NECTIN4	2	ENAH	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	VASP	0	affinity chromatography technology	Kirli K (2015)	1
SEMA6A	3	EVL	4	affinity chromatography technology	Klostermann A (2000)	1
HNRNPL	3	ENAH	0	affinity chromatography technology	Fei T (2017)	1
XPO1	8	EVL	4	affinity chromatography technology	Kirli K (2015)	1
ZDHHC17	1	EVL	4	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
EVL	4	EVL	4	two hybrid	Rolland T (2014)	1
BAG3	4	HTT	14	affinity chromatography technology	Hein MY (2015)	1
U2AF2	7	EVL	4	affinity chromatography technology	Whisenant TC (2015)	1
APBB1	3	VASP	0	pull down	Ingham RJ (2005)	1
PRPF40A	5	WASF2	0	pull down	Ingham RJ (2005)	1
TERF1	1	ABL1	9	affinity chromatography technology, affinity chromatography technology	Kishi S (2001), Kishi S (2001)	2
TES	1	ENAH	0	affinity chromatography technology, pull down, affinity chromatography technology	Garvalov BK (2003), Garvalov BK (2003), Sala S (2017)	3
APBB1	3	EVL	4	pull down, pull down	Lambrechts A (2000), Ingham RJ (2005)	2
EVL	4	DDX49	0	affinity chromatography technology	Huttlin EL (2017)	1
SPTAN1	9	EVL	4	two hybrid, affinity chromatography technology	Rotter B (2005), Rotter B (2005)	2
TCERG1	3	WASF2	0	pull down	Ingham RJ (2005)	1
DNMBP	9	ENAH	0	pull down	Salazar MA (2003)	1
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
TCERG1	3	EVL	4	pull down	Ingham RJ (2005)	1
NECTIN4	2	EVL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
HTT	14	ZDHHC17	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid	Faber PW (1998), Singaraja RR (2002), Singaraja RR (2002), Singaraja RR (2002), Suter B (2013), Butland SL (2014)	6
HNRNPL	3	SEMA6A	3	affinity chromatography technology	Fei T (2017)	1
DNMBP	9	VASP	0	pull down	Salazar MA (2003)	1
NAP1L5	1	EVL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WASF2	0	ABI3	1	affinity chromatography technology, pull down	Hirao N (2006), Hirao N (2006)	2
HTT	14	PRPF40A	5	two hybrid, pull down, two hybrid	Faber PW (1998), Faber PW (1998), Goehler H (2004)	3
VASP	0	EVL	4	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
EVL	4	WASF2	0	affinity chromatography technology	Huttlin EL (2017)	1
TERF1	1	SPTAN1	9	affinity chromatography technology	Giannone RJ (2010)	1
PRPF40A	5	VASP	0	pull down	Ingham RJ (2005)	1
BAG3	4	NAP1L5	1	affinity chromatography technology	Chen Y (2013)	1
EVL	4	TRMT61A	0	affinity chromatography technology	Huttlin EL (2017)	1
TERF1	1	BAG3	4	affinity chromatography technology	Giannone RJ (2010)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
TERF1	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
TES	1	EVL	4	pull down	Rotter B (2005)	1
TCERG1	3	U2AF2	7	affinity chromatography technology, pull down, pull down	Lin KT (2004), Ingham RJ (2005), Lin KT (2004)	3
PRPF40A	5	EVL	4	pull down	Ingham RJ (2005)	1
PRPF40A	5	TCERG1	3	biochemical	Havugimana PC (2012)	1
EVL	4	FBLIM1	2	affinity chromatography technology	Huttlin EL (2017)	1
EVL	4	UBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
TES	1	VASP	0	affinity chromatography technology, pull down, affinity chromatography technology	Garvalov BK (2003), Garvalov BK (2003), Sala S (2017)	3
TCERG1	3	HTT	14	pull down, two hybrid	Holbert S (2001), Goehler H (2004)	2
XPO1	8	UBP1	2	affinity chromatography technology	Kirli K (2015)	1
XIRP1	9	ENAH	0	two hybrid	van der Ven PF (2006)	1
POT1	2	BAG3	4	two hybrid	Lee OH (2011)	1
EVL	4	TRIM9	3	two hybrid	Rolland T (2014)	1
HNRNPL	3	EVL	4	affinity chromatography technology	Fei T (2017)	1
APBB1	3	WASF2	0	pull down	Ingham RJ (2005)	1
LYN	2	EVL	4	pull down	Lambrechts A (2000)	1
U2AF2	7	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Whisenant TC (2015), Fei T (2017)	2
TERF1	1	U2AF2	7	pull down, affinity chromatography technology, affinity chromatography technology	Kim J (2014), Kim J (2014), Kim J (2014)	3
EVL	4	DNMBP	9	two hybrid, pull down	Salazar MA (2003), Salazar MA (2003)	2