Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
NELFCD	rs2273359	CG	diuretics	efficacy	no	There is potential for strand confusion with a CG SNP, and it is not clear with respect to the positive chromosomal strand which allele is associated with better response. The article text states that no GG were observed, but table 2 lists C as the low frequency allele. The association did not reach genome-wide significance when only PEAR + GERA were analyzed, but this SNP was selected for replication in NORDIL, where the association also did not reach significance. This association approached genome-wide significance in the meta-analysis of PEAR + GERA + NORDIL. Observations: 8.21 mm Hg decrease in reduction of systolic blood pressure per C allele in PEAR + GERA, 7.79 mm Hg decrease in reduction in systolic blood pressure per C allele in NORDIL and 8.15 mm Hg decrease in reduction of systolic blood pressure per C allele in PEAR + GERA + NORDIL.	Genotype CG is associated with increased response to diuretics, hydrochlorothiazide or Thiazides, plain in people with Hypertension as compared to genotype CC.	23753411	1183631267