PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBA2	0	UNK	3	biochemical	Havugimana PC (2012)	1
VTA1	1	CHMP5	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Kuang Z (2011), Ma YM (2007), Tsang HT (2006), Huttlin EL (2017)	4
SNCA	0	CHMP5	0	biochemical	Kristensen AR (2012)	1
CHMP5	0	RAB5A	0	imaging technique	Kumar B (2016)	1
CHMP5	0	CHMP1B	0	two hybrid	Tsang HT (2006)	1
TSG101	1	TFG	3	affinity chromatography technology, affinity chromatography technology	Schlundt A (2009), Hein MY (2015)	2
CHMP5	0	TCP10L	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB7A	0	RAB5A	0	two hybrid, biochemical, biochemical	Bucci C (1999), Havugimana PC (2012), Wan C (2015)	3
8339	0	CHMP5	0	bioid	Lambert JP (2015)	1
EWSR1	2	BAG6	2	bioid	Elzi DJ (2014)	1
CHMP1A	3	VPS4B	3	two hybrid	von Schwedler UK (2003)	1
CAMK2A	6	CHMP5	0	affinity chromatography technology	Ewing RM (2007)	1
STMN4	1	VTA1	1	affinity chromatography technology	Huttlin EL (2017)	1
EWSR1	2	CHMP5	0	bioid	Elzi DJ (2014)	1
HNRNPD	3	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
UBA2	0	PSMA4	0	biochemical	Wan C (2015)	1
VPS4B	3	CHMP2A	3	two hybrid	von Schwedler UK (2003)	1
RAB7A	0	CHMP2A	3	affinity chromatography technology	Hein MY (2015)	1
TSG101	1	RAB7A	0	imaging technique	Kumar B (2016)	1
CHMP5	0	PSMA4	0	biochemical	Wan C (2015)	1
EWSR1	2	TFG	3	two hybrid, bioid	Rolland T (2014), Elzi DJ (2014)	2
RAB5A	0	SNCA	0	affinity chromatography technology	Dalfo E (2004)	1
STAMBP	2	CHMP1A	3	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	9
TFG	3	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
AURKA	1	UBA2	0	genetic interference	Horlbeck MA (2018)	1
CHMP4B	2	CHMP2A	3	imaging technique, affinity chromatography technology	Olmos Y (2015), Hein MY (2015)	2
CHMP2A	3	MITD1	0	affinity chromatography technology	Tsang HT (2006)	1
CHMP4A	1	VPS4B	3	biochemical	Havugimana PC (2012)	1
CHMP5	0	PDCD10	1	two hybrid	Tsang HT (2006)	1
STAMBP	2	CHMP1B	0	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, two hybrid	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Rolland T (2014)	10
UNK	3	PDCD10	1	affinity chromatography technology	Murn J (2015)	1
TFG	3	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
SGTB	2	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
ATP6V1B1	4	MITD1	0	affinity chromatography technology	Nylandsted J (2011)	1
CHMP5	0	UBA2	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CHMP5	0	STMN4	1	affinity chromatography technology	Huttlin EL (2017)	1
UNK	3	HNRNPL	3	affinity chromatography technology	Murn J (2015)	1
VPS4A	4	CHMP3	0	affinity chromatography technology	Kuang Z (2011)	1
CDH1	4	CHMP5	0	bioid	Guo Z (2014)	1
HNRNPD	3	HNRNPL	3	biochemical	Havugimana PC (2012)	1
CHMP2A	3	UBA2	0	genetic interference	Horlbeck MA (2018)	1
CDH1	4	PXN	1	bioid	Guo Z (2014)	1
SGTB	2	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	ISG15	0	affinity chromatography technology, affinity chromatography technology	Pincetic A (2010), Zhao C (2005)	2
CHMP3	0	CHMP1B	0	biochemical	Wan C (2015)	1
TFG	3	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
VPS4A	4	CHMP1B	0	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	3
HNRNPL	3	RAB7A	0	affinity chromatography technology	Fei T (2017)	1
TFG	3	CHMP3	0	affinity chromatography technology	Hein MY (2015)	1
ATP6V1B1	4	CHMP1A	3	affinity chromatography technology	Nylandsted J (2011)	1
VPS4B	3	VTA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFG	3	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
ISG15	0	HNRNPL	3	affinity chromatography technology	Zhao C (2005)	1
CHMP3	0	CHMP4B	2	two hybrid, two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Tsang HT (2006), Wan C (2015), Hein MY (2015)	4
CHMP4A	1	VPS4A	4	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Strack B (2003), Tsang HT (2006)	3
APPBP2	3	CHMP5	0	two hybrid	Rual JF (2005)	1
CHMP4A	1	CHMP3	0	two hybrid	von Schwedler UK (2003)	1
CHMP5	0	GTF3A	5	two hybrid	Tsang HT (2006)	1
UNK	3	CHMP5	0	affinity chromatography technology	Murn J (2015)	1
EWSR1	2	PSMA4	0	bioid	Elzi DJ (2014)	1
VPS4A	4	CHMP2A	3	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
TFG	3	CHMP4A	1	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	STAMBP	2	two hybrid	Wang J (2011)	1
CHMP1A	3	CHMP1B	0	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
AURKA	1	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	CHMP5	0	two hybrid	Tsang HT (2006)	1
CHMP5	0	HABP4	1	biochemical	Wan C (2015)	1
BAG6	2	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
STAMBP	2	CHMP4A	1	two hybrid, two hybrid	Row PE (2007), Tsang HT (2006)	2
ATP6V1B1	4	CHMP4B	2	affinity chromatography technology	Nylandsted J (2011)	1
CHMP1A	3	VPS4A	4	affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid	Howard TL (2001), Howard TL (2001), Howard TL (2001), von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	6
TCP10L	0	SH3KBP1	1	affinity chromatography technology	Huttlin EL (2017)	1
CHMP5	0	URGCP	4	two hybrid	Tsang HT (2006)	1
ATP6V1B1	4	CHMP1B	0	affinity chromatography technology	Nylandsted J (2011)	1
HNRNPD	3	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
VPS4B	3	CHMP5	0	two hybrid	Rolland T (2014)	1
TSG101	1	CHMP5	0	affinity chromatography technology, imaging technique	Kumar B (2016), Kumar B (2016)	2
VTA1	1	CHMP2A	3	affinity chromatography technology, affinity chromatography technology	Kuang Z (2011), Huttlin EL (2017)	2
CHMP4B	2	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
CHMP4B	2	CHMP4A	1	two hybrid	Tsang HT (2006)	1
ATP6V1B1	4	CHMP5	0	affinity chromatography technology	Nylandsted J (2011)	1
TSG101	1	BAG6	2	affinity chromatography technology	Schlundt A (2009)	1
TFG	3	CHMP2A	3	affinity chromatography technology	Hein MY (2015)	1
STAMBP	2	CHMP4B	2	two hybrid, two hybrid, two hybrid	Row PE (2007), Tsang HT (2006), Tsang HT (2006)	3
CDH1	4	SH3KBP1	1	bioid	Guo Z (2014)	1
AURKA	1	RPL38	0	affinity chromatography technology	Fogeron ML (2013)	1
CHMP5	0	PXN	1	biochemical	Kristensen AR (2012)	1
CHMP5	0	CHMP4B	2	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
TFG	3	MITD1	0	affinity chromatography technology	Hein MY (2015)	1
VTA1	1	CHMP3	0	affinity chromatography technology	Kuang Z (2011)	1
CHMP4B	2	MITD1	0	affinity chromatography technology	Hein MY (2015)	1
RAB7A	0	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
TSG101	1	SH3KBP1	1	biochemical	Wan C (2015)	1
TSG101	1	RAB5A	0	imaging technique	Kumar B (2016)	1
CHMP5	0	SH3KBP1	1	affinity chromatography technology	Huttlin EL (2017)	1
CHMP5	0	ZNF142	5	two hybrid	Tsang HT (2006)	1
CHMP4B	2	TSG101	1	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	CHMP4B	2	bioid	Guo Z (2014)	1
CHMP2A	3	STAMBP	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Kyuuma M (2006), Agromayor M (2006), Agromayor M (2006), Huttlin EL (2017)	4
CHMP5	0	ZNF91	2	two hybrid	Tsang HT (2006)	1
UNK	3	TFG	3	affinity chromatography technology	Murn J (2015)	1
CHMP5	0	CHMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CHMP5	0	RAB7A	0	imaging technique	Kumar B (2016)	1
VPS4A	4	CHMP5	0	affinity chromatography technology	Kuang Z (2011)	1
VPS4A	4	CHMP4B	2	two hybrid, two hybrid	Tsang HT (2006), Tsang HT (2006)	2
UNK	3	RAB5A	0	affinity chromatography technology	Murn J (2015)	1
CHMP2A	3	CHMP5	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	SH3KBP1	1	affinity chromatography technology	Schroeder B (2012)	1
STAMBP	2	CHMP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Kyuuma M (2006), Kyuuma M (2006), Kyuuma M (2006), Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Ma YM (2007), Ma YM (2007), McCullough J (2006), Zamborlini A (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Rolland T (2014), Huttlin EL (2015), Lata S (2008), Huttlin EL (2017)	20
CHMP5	0	CHMP4A	1	two hybrid, biochemical	Tsang HT (2006), Wan C (2015)	2
CHMP5	0	SMARCA4	19	two hybrid	Tsang HT (2006)	1
CHMP4B	2	CHMP1B	0	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
CHMP2A	3	CHMP3	0	affinity chromatography technology, two hybrid	Kyuuma M (2006), Tsang HT (2006)	2
ATP6V1B1	4	CHMP3	0	affinity chromatography technology	Nylandsted J (2011)	1
RAB7A	0	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
EWSR1	2	HNRNPD	3	bioid	Elzi DJ (2014)	1
CHMP5	0	MITD1	0	two hybrid	Rolland T (2014)	1
8339	0	CHMP4B	2	bioid	Lambert JP (2015)	1
CHMP5	0	SNRPD2	0	biochemical	Wan C (2015)	1
CHMP5	0	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
CHMP5	0	RPL38	0	two hybrid	Tsang HT (2006)	1
AURKA	1	HNRNPD	3	biochemical	Wan C (2015)	1
HNRNPL	3	CHMP5	0	affinity chromatography technology	Fei T (2017)	1
TSG101	1	EWSR1	2	affinity chromatography technology	Schlundt A (2009)	1
VPS4A	4	VPS4B	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACTR6	3	CHMP5	0	biochemical	Wan C (2015)	1
VPS4A	4	VTA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pincetic A (2010), Huttlin EL (2015), Huttlin EL (2017)	3
8339	0	ACTR6	3	bioid	Lambert JP (2015)	1