Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PDGFRA 5156 CEDIRANIB CHEMBL491473 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
PDGFRA 5156 PHENOBARBITAL CHEMBL40 inhibitor GuideToPharmacologyInteractions
PDGFRA 5156 ENMD-2076 CHEMBL482968 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions
PDGFRA 5156 LUCITANIB CHEMBL2220486 inhibitor GuideToPharmacologyInteractions
PDGFRA 5156 MASITINIB CHEMBL1908391 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, MyCancerGenomeClinicalTrial
PDGFRA 5156 PEGPLERANIB SODIUM CHEMBL3301576 TdgClinicalTrial
PDGFRA 5156 MOTESANIB CHEMBL572881 inhibitor MyCancerGenome, TdgClinicalTrial, ChemblInteractions
PDGFRA 5156 TELATINIB CHEMBL2079588 TdgClinicalTrial
PDGFRA 5156 DIPHENIDOL CHEMBL936 CKB
PDGFRA 5156 Famitinib CHEMBL3545026 inhibitor ChemblInteractions
PDGFRA 5156 ORANTINIB CHEMBL274654 inhibitor ChemblInteractions
PDGFRA 5156 NINTEDANIB CHEMBL502835 inhibitor TALC, MyCancerGenome, TdgClinicalTrial, ClearityFoundationClinicalTrial, GuideToPharmacologyInteractions
PDGFRA 5156 XL-820 CHEMBL3545402 inhibitor TdgClinicalTrial, ChemblInteractions, DrugBank
PDGFRA 5156 OLARATUMAB CHEMBL1743049 antagonist, antibody MyCancerGenome, TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank, FDA 24816152, 27291995
PDGFRA 5156 CRENOLANIB CHEMBL2105728 inhibitor MyCancerGenome, CKB, GuideToPharmacologyInteractions, ChemblInteractions, CGI, CIViC, DoCM 24132921, 16638875, 22718859, 12949711, 15685537, 15146165, 26130666, 15928335, 18794084, 22745105, 16954519, 14645423, 25157968
PDGFRA 5156 QUIZARTINIB CHEMBL576982 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
PDGFRA 5156 MIDOSTAURIN CHEMBL608533 inhibitor MyCancerGenome, ChemblInteractions
PDGFRA 5156 GEFITINIB CHEMBL939 CKB 22323597
PDGFRA 5156 SU-14813 CHEMBL3545160 inhibitor ChemblInteractions
PDGFRA 5156 ILORASERTIB CHEMBL1980297 inhibitor ChemblInteractions
PDGFRA 5156 IMATINIB CHEMBL941 inhibitor OncoKB, MyCancerGenome, CIViC, FDA, TEND, TdgClinicalTrial, CGI, CKB, DoCM 25905001, 17087936, 12949711, 24963404, 22718859, 15928335, 18955458, 23752188, 22745105, 15685537, 18794084, 12944919, 17555450, 12660384, 16498388, 14504092, 16845659, 15034867, 16754777, 12781364, 19212337, 24407160, 27021554, 21224473, 16954519, 26130666, 14645423, 24456122, 25658984, 24132921, 16638875, 22323597, 16357008, 22328973, 28514312, 15146165, 25157968
PDGFRA 5156 SUNITINIB CHEMBL535 inhibitor DrugBank, TdgClinicalTrial, MyCancerGenomeClinicalTrial, TEND, CGI, CIViC, CKB, DoCM 16638875, 22718859, 19366796, 18955458, 12949711, 15685537, 15146165, 26130666, 15928335, 18794084, 22745105, 16954519, 14645423, 25157968
PDGFRA 5156 PAZOPANIB CHEMBL477772 inhibitor TALC, MyCancerGenome, DrugBank, MyCancerGenomeClinicalTrial 17288876
PDGFRA 5156 PONATINIB CHEMBL1171837 inhibitor CKB, CIViC, DrugBank 19878872, 24407160, 22328973
PDGFRA 5156 RAMUCIRUMAB CHEMBL1743062 antibody TALC, MyCancerGenome
PDGFRA 5156 X-82 CHEMBL3545401 inhibitor MyCancerGenome, ChemblInteractions
PDGFRA 5156 AXITINIB CHEMBL1289926 TdgClinicalTrial
PDGFRA 5156 SORAFENIB TOSYLATE CHEMBL1200485 inhibitor MyCancerGenomeClinicalTrial
PDGFRA 5156 TANDUTINIB CHEMBL124660 inhibitor MyCancerGenome
PDGFRA 5156 VATALANIB CHEMBL101253 inhibitor TdgClinicalTrial, ChemblInteractions
PDGFRA 5156 SORAFENIB CHEMBL1336 inhibitor MyCancerGenomeClinicalTrial
PDGFRA 5156 CARBOPLATIN CHEMBL1351 CKB 28514312
PDGFRA 5156 PAZOPANIB HYDROCHLORIDE CHEMBL1201733 inhibitor ChemblInteractions
PDGFRA 5156 NINTEDANIB ESYLATE CHEMBL3039504 inhibitor ChemblInteractions
PDGFRA 5156 BECAPLERMIN CHEMBL1201556 agonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 1702511, 12632922, 10070317, 14506245, 7665222
PDGFRA 5156 AMUVATINIB CHEMBL2103851 inhibitor MyCancerGenome, TdgClinicalTrial, ChemblInteractions, DrugBank
PDGFRA 5156 DOVITINIB CHEMBL522892 inhibitor ClearityFoundationClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions
PDGFRA 5156 CHEMBL1081312 CHEMBL1081312 inhibitor GuideToPharmacologyInteractions
PDGFRA 5156 DASATINIB CHEMBL1421 OncoKB, CKB, CGI, DoCM 15928335, 18794084, 17419150, 22328973, 16638875, 22718859, 12949711, 15685537, 15146165, 26130666, 22745105, 16954519, 14645423, 25157968
PDGFRA 5156 TOVETUMAB CHEMBL2364651 antibody TALC, MyCancerGenome, TTD
PDGFRA 5156 TAK-593 CHEMBL2180604 inhibitor ChemblInteractions, TTD
PDGFRA 5156 LENVATINIB CHEMBL1289601 TdgClinicalTrial
PDGFRA 5156 PACLITAXEL CHEMBL428647 CKB 28514312
PDGFRA 5156 ENMD-981693 CHEMBL52885 inhibitor ChemblInteractions
PDGFRA 5156 SU-014813 CHEMBL1721885 inhibitor ChemblInteractions
PDGFRA 5156 FORETINIB CHEMBL1230609 inhibitor ChemblInteractions
PDGFRA 5156 XL-999 CHEMBL3545285 inhibitor ChemblInteractions
PDGFRA 5156 LINIFANIB CHEMBL223360 inhibitor ChemblInteractions
PDGFRA 5156 SUNITINIB MALATE CHEMBL1567 inhibitor ChemblInteractions
PDGFRA 5156 NILOTINIB CHEMBL255863 inhibitor CKB, MyCancerGenomeClinicalTrial 18794084
PDGFRA 5156 BENZONATATE CHEMBL1374379 CKB 25805799
PDGFRA 5156 REGORAFENIB CHEMBL1946170 inhibitor CKB, ChemblInteractions, CGI, DrugBank, MyCancerGenomeClinicalTrial 25905001

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PDGFRA rs1800812 T imatinib dosage no No significant association between genotype and chance of requiring an imatinib dose reduction. Allele T is not associated with dose of imatinib in people with Gastrointestinal Stromal Tumors as compared to allele G. 30713339 1450933468
PDGFRA rs1800813 G imatinib dosage no No significant association between genotype and chance of requiring an imatinib dose reduction. Allele G is not associated with dose of imatinib in people with Gastrointestinal Stromal Tumors as compared to allele A. 30713339 1450933478
PDGFRA rs2228230 T imatinib dosage no No significant association between genotype and chance of requiring an imatinib dose reduction. Allele T is not associated with dose of imatinib in people with Gastrointestinal Stromal Tumors as compared to allele C. 30713339 1450933489
PDGFRA rs1800810 G imatinib dosage no No significant association between genotype and chance of requiring an imatinib dose reduction. Allele G is not associated with dose of imatinib in people with Gastrointestinal Stromal Tumors as compared to allele C. 30713339 1450933458
PDGFRA rs35597368 T imatinib dosage no No significant association between genotype and chance of requiring an imatinib dose reduction. Allele T is not associated with dose of imatinib in people with Gastrointestinal Stromal Tumors as compared to allele C. 30713339 1450933497