PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AZIN1	1	TDP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
PSEN1	11	TDP2	2	two hybrid	Wang J (2011)	1
TNFRSF1B	4	TRAF3	1	pull down, affinity chromatography technology	Mosialos G (1995), Mosialos G (1995)	2
GORASP1	1	TDP2	2	affinity chromatography technology	Huttlin EL (2017)	1
SMAD3	1	TDP2	2	two hybrid	Wang J (2011)	1
CD40	3	TRAF5	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Ishida TK (1996), Werneburg BG (2001), Peters AL (2010), Mizushima S (1998), Basaki Y (2002), He B (2010), Hostager BS (2010), Hostager BS (2010)	9
OTUB1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Li S (2010), Peng Y (2014)	2
MAPK6	1	TCEAL1	3	affinity chromatography technology	Rodriguez J (2016)	1
PARK7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2010), Zucchelli S (2010)	2
OTUB1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
AKAP9	13	TDP2	2	two hybrid	Wang J (2011)	1
ETS1	4	TDP2	2	two hybrid, pull down, pull down, affinity chromatography technology	Pei H (2003), Pei H (2003), Pei H (2003), Pei H (2003)	4
TCEAL1	3	TDP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUMO2	0	TDP2	2	two hybrid, pull down	Hecker CM (2006), Hecker CM (2006)	2
SRPK2	1	TDP2	2	enzymatic study	Varjosalo M (2013)	1
MAPK6	1	GORASP1	1	two hybrid	Vinayagam A (2011)	1
SNX13	3	TDP2	2	two hybrid	Wang J (2011)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
TRAF6	0	TDP2	2	affinity chromatography technology	Pype S (2000)	1
ETS1	4	SMAD3	1	imaging technique	Chen TC (2014)	1
DLX3	2	TDP2	2	two hybrid	Wang J (2011)	1
SKIL	3	TDP2	2	two hybrid	Colland F (2004)	1
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
MAPK6	1	TDP2	2	two hybrid	Vinayagam A (2011)	1
SUMO3	0	TDP2	2	pull down	Hecker CM (2006)	1
PLA2G10	0	TDP2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF8	2	TRAF2	1	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Aizawa S (1997), Aizawa S (1997), Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Horie R (2002), Huttlin EL (2017)	7
EPS8	1	TDP2	2	two hybrid	Wang J (2011)	1
TNFRSF8	2	TRAF5	1	pull down, affinity chromatography technology, pull down	Aizawa S (1997), Aizawa S (1997), Mizushima S (1998)	3
TRAF3	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
TRAF6	0	TNFRSF1B	4	affinity chromatography technology	Khursigara G (1999)	1
CD40	3	TRAF3	1	pull down, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Hu HM (1994), Hu HM (1994), Hu HM (1994), Ni CZ (2000), Roy N (1997), Qiao G (2007), Mosialos G (1995), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Li C (2003), Boucher LM (1997), Graham JP (2009), Sato T (1995), Sato T (1995), Sato T (1995), Deregibus MC (2003), Hostager BS (1999), Basaki Y (2002), Cheng G (1995), Miliara S (2013), Elmetwali T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	27
ATP5G2	0	TDP2	2	two hybrid	Wang J (2011)	1
ATXN1	2	SUMO1	0	two hybrid	Kang S (2010)	1
C2orf88	0	TDP2	2	two hybrid	Wang J (2011)	1
TRAF5	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
UBE2I	0	TRAF3	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Miliara S (2013), Miliara S (2013), Miliara S (2013), Miliara S (2013)	4
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
PARK7	0	UBE2I	0	two hybrid	Junn E (2005)	1
TRAF6	0	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Powell JC (2009), Elzinga BM (2009), Elzinga BM (2009), Yan R (2013), Yan R (2013), Gudey SK (2014), Gudey SK (2014)	7
MAPK6	1	SUMO2	0	affinity chromatography technology	Rodriguez J (2016)	1
SUMO1	0	TDP2	2	two hybrid, pull down	Lee BH (2003), Hecker CM (2006)	2
TAP1	0	TDP2	2	two hybrid	Wang J (2011)	1
TNFRSF8	2	TRAF3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
WBP2	0	TDP2	2	two hybrid	Lim SK (2016)	1
OTUB1	0	TDP2	2	affinity chromatography technology	Scholz CC (2016)	1
RSBN1	3	TDP2	2	affinity chromatography technology	Huttlin EL (2017)	1
PARK7	0	TDP2	2	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2009), Zucchelli S (2009)	2
PARK7	0	SUMO1	0	two hybrid	Junn E (2005)	1
LYPD4	1	TDP2	2	affinity chromatography technology	Huttlin EL (2017)	1
RAB11A	4	TDP2	2	two hybrid	Wang J (2011)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
CD40	3	TDP2	2	two hybrid, affinity chromatography technology	Pype S (2000), Pype S (2000)	2
TNFRSF8	2	TDP2	2	affinity chromatography technology	Pype S (2000)	1
ETS1	4	UBE2I	0	two hybrid, pull down	Hahn SL (1997), Hahn SL (1997)	2
ATXN1	2	TRAF2	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
TNFRSF1B	4	TDP2	2	affinity chromatography technology, two hybrid	Pype S (2000), Pype S (2000)	2
ATXN1	2	TDP2	2	two hybrid	Suter B (2013)	1
UBE2I	0	TDP2	2	two hybrid	Lee BH (2003)	1
TRAF2	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
JAM2	0	TDP2	2	two hybrid	Wang J (2011)	1
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7