PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NSG2	0	ECM1	1	affinity chromatography technology	Huttlin EL (2017)	1
SERPINH1	2	NSG2	0	two hybrid	Vinayagam A (2011)	1
NSG2	0	HSPA5	0	affinity chromatography technology	Huttlin EL (2017)	1
SUPT4H1	1	NSG2	0	two hybrid	Vinayagam A (2011)	1
HSPA5	0	SERPINH1	2	biochemical	Havugimana PC (2012)	1
NDUFA2	0	NSG2	0	two hybrid	Vinayagam A (2011)	1
TNNT1	0	ZNF768	2	two hybrid	Vinayagam A (2011)	1
NSG2	0	SLC35F6	0	two hybrid	Stelzl U (2005)	1
TNNT1	0	NSG2	0	two hybrid	Vinayagam A (2011)	1
RPS27	0	NSG2	0	two hybrid	Vinayagam A (2011)	1
SERPINH1	2	SLC35F6	0	two hybrid	Stelzl U (2005)	1
TSPAN6	0	NSG2	0	two hybrid	Vinayagam A (2011)	1
APOC1	1	NSG2	0	two hybrid	Vinayagam A (2011)	1
NSG2	0	ZNF768	2	two hybrid	Vinayagam A (2011)	1
NSG2	0	ASAH1	0	affinity chromatography technology	Huttlin EL (2017)	1
UCHL3	1	NSG2	0	two hybrid	Vinayagam A (2011)	1