PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KLF13	3	SREBF2	5	pull down	Natesampillai S (2006)	1
SH3KBP1	1	KLF13	3	affinity chromatography technology	Havrylov S (2009)	1
SREBF1	5	SREBF2	5	fluorescent resonance energy transfe	Zoumi A (2005)	1
EP300	36	KLF13	3	enzymatic study	Song CZ (2003)	1
CREBBP	29	SREBF2	5	far western blotting, affinity chromatography technology, affinity chromatography technology	Oliner JD (1996), Oliner JD (1996), Nath S (2014)	3
CHCHD10	1	KLF13	3	affinity chromatography technology	Huttlin EL (2017)	1
SERPINH1	2	KLF13	3	affinity chromatography technology, affinity chromatography technology	Song CZ (2002), Song CZ (2002)	2
KLF13	3	SIN3A	13	pull down	Zhang JS (2001)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
KLF13	3	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology, enzymatic study	Song CZ (2002), Song CZ (2002), Song CZ (2002), Song CZ (2002)	4
KLF13	3	SREBF1	5	pull down	Natesampillai S (2006)	1
PCBD1	0	KLF13	3	two hybrid	Ravasi T (2010)	1
SH3KBP1	1	SERPINH1	2	affinity chromatography technology	Havrylov S (2009)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
EP300	36	SREBF2	5	far western blotting	Oliner JD (1996)	1
EP300	36	SREBF1	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, enzymatic study	Sundqvist A (2003), Giandomenico V (2003), Giandomenico V (2003), Naeaer AM (1999), Naeaer AM (1999), Ebmeier CC (2010), Ponugoti B (2010)	7
KLF13	3	KAT2B	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Song CZ (2002), Song CZ (2002), Song CZ (2002), Song CZ (2002), Song CZ (2003)	5
CREBBP	29	SREBF1	5	far western blotting, affinity chromatography technology, biochemical, pull down, pull down, imaging technique, pull down, pull down, pull down	Oliner JD (1996), Oliner JD (1996), Naeaer AM (1999), Naeaer AM (1999), Naeaer AM (1998), Yang F (2006), Yang F (2006), Yang F (2006), Ericsson J (1998)	9
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10