PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VTA1	1	CHMP5	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Kuang Z (2011), Ma YM (2007), Tsang HT (2006), Huttlin EL (2017)	4
CHMP5	0	CHMP1B	0	two hybrid	Tsang HT (2006)	1
SIX2	4	APP	1	pull down	Olah J (2011)	1
CHMP2B	0	CHMP2A	3	biochemical	Wan C (2015)	1
ATP6V1B1	4	CHMP2B	0	affinity chromatography technology	Nylandsted J (2011)	1
SMAD5	2	CHMP3	0	two hybrid	Colland F (2004)	1
VAX2	0	CHMP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHMP1B	0	RAB11A	4	two hybrid	Tsang HT (2006)	1
CHMP3	0	RAB11A	4	two hybrid	Tsang HT (2006)	1
FBXO7	1	CHMP2B	0	enzymatic study	Teixeira FR (2016)	1
TFG	3	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
CHMP4B	2	CHMP2A	3	imaging technique, affinity chromatography technology	Olmos Y (2015), Hein MY (2015)	2
STAMBP	2	CHMP1B	0	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, two hybrid	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Rolland T (2014)	10
TFG	3	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
VPS4A	4	CHMP3	0	affinity chromatography technology	Kuang Z (2011)	1
CHMP3	0	TNPO3	16	two hybrid	Tsang HT (2006)	1
CHMP3	0	CHMP1B	0	biochemical	Wan C (2015)	1
TFG	3	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
VPS4A	4	CHMP1B	0	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	3
TFG	3	CHMP3	0	affinity chromatography technology	Hein MY (2015)	1
DAXX	5	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
CHMP3	0	CHMP4B	2	two hybrid, two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Tsang HT (2006), Wan C (2015), Hein MY (2015)	4
SIX2	4	CHMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CHMP4A	1	VPS4A	4	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Strack B (2003), Tsang HT (2006)	3
CHMP4A	1	CHMP3	0	two hybrid	von Schwedler UK (2003)	1
DAXX	5	CHMP3	0	affinity chromatography technology	Hein MY (2015)	1
VPS4A	4	CHMP2A	3	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
TFG	3	CHMP4A	1	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	STAMBP	2	two hybrid	Wang J (2011)	1
STAMBP	2	CHMP4A	1	two hybrid, two hybrid	Row PE (2007), Tsang HT (2006)	2
FBXO7	1	CHMP3	0	enzymatic study	Teixeira FR (2016)	1
VAX2	0	CHMP4A	1	affinity chromatography technology	Huttlin EL (2017)	1
ATP6V1B1	4	CHMP4B	2	affinity chromatography technology	Nylandsted J (2011)	1
ATP6V1B1	4	CHMP1B	0	affinity chromatography technology	Nylandsted J (2011)	1
CXorf56	0	APP	1	pull down	Olah J (2011)	1
SIX2	4	CHMP2A	3	affinity chromatography technology	Huttlin EL (2017)	1
VTA1	1	CHMP2A	3	affinity chromatography technology, affinity chromatography technology	Kuang Z (2011), Huttlin EL (2017)	2
CHMP4B	2	CHMP4A	1	two hybrid	Tsang HT (2006)	1
ATP6V1B1	4	CHMP5	0	affinity chromatography technology	Nylandsted J (2011)	1
TFG	3	CHMP2A	3	affinity chromatography technology	Hein MY (2015)	1
CHMP2B	0	CHMP3	0	two hybrid	Tsang HT (2006)	1
VAV2	6	CHMP3	0	two hybrid	Thalappilly S (2008)	1
STAMBP	2	CHMP4B	2	two hybrid, two hybrid, two hybrid	Row PE (2007), Tsang HT (2006), Tsang HT (2006)	3
CHMP5	0	CHMP4B	2	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
IGFBP7	1	CHMP3	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Wilson EM (2001), Wilson EM (2001), Wilson EM (2001)	3
CHMP2B	0	CHMP4B	2	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
VTA1	1	CHMP3	0	affinity chromatography technology	Kuang Z (2011)	1
SMAD1	0	APP	1	pull down	Olah J (2011)	1
CHMP2A	3	STAMBP	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Kyuuma M (2006), Agromayor M (2006), Agromayor M (2006), Huttlin EL (2017)	4
VTA1	1	APP	1	pull down	Olah J (2011)	1
CHMP5	0	CHMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
VPS4A	4	CHMP5	0	affinity chromatography technology	Kuang Z (2011)	1
VPS4A	4	CHMP4B	2	two hybrid, two hybrid	Tsang HT (2006), Tsang HT (2006)	2
CHMP2A	3	CHMP5	0	affinity chromatography technology	Huttlin EL (2017)	1
CXorf56	0	CHMP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAMBP	2	CHMP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Kyuuma M (2006), Kyuuma M (2006), Kyuuma M (2006), Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Ma YM (2007), Ma YM (2007), McCullough J (2006), Zamborlini A (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Rolland T (2014), Huttlin EL (2015), Lata S (2008), Huttlin EL (2017)	20
CHMP5	0	CHMP4A	1	two hybrid, biochemical	Tsang HT (2006), Wan C (2015)	2
CHMP4B	2	CHMP1B	0	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
CHMP2A	3	CHMP3	0	affinity chromatography technology, two hybrid	Kyuuma M (2006), Tsang HT (2006)	2
ATP6V1B1	4	CHMP3	0	affinity chromatography technology	Nylandsted J (2011)	1
SMAD1	0	CHMP3	0	two hybrid	Colland F (2004)	1
MEPCE	1	CHMP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHMP3	0	APP	1	pull down	Olah J (2011)	1
CHMP3	0	CHMP3	0	pull down, two hybrid	Zamborlini A (2006), Tsang HT (2006)	2
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1
VPS4A	4	VTA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pincetic A (2010), Huttlin EL (2015), Huttlin EL (2017)	3