PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	HSPA4	3	affinity chromatography technology	Choudhury NR (2017)	1
GSK3B	1	NUB1	2	affinity chromatography technology, affinity chromatography technology	Richet E (2012), Richet E (2012)	2
TP53	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
PSMD4	1	PSMD2	2	biochemical, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Havugimana PC (2012), Su V (2013), Kristensen AR (2012), Wan C (2015), Sparks A (2014)	6
SEM1	0	PSMD2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baillat D (2005), Wei SJ (2008), Krogan NJ (2004), Krogan NJ (2004)	4
ECT2	2	PSMD4	1	affinity chromatography technology	Woods NT (2012)	1
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
ECT2	2	NUB1	2	affinity chromatography technology	Woods NT (2012)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
NUB1	2	UBD	0	affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Hipp MS (2004), Hipp MS (2004), Rani N (2012), Rani N (2012), Schmidtke G (2006), Schmidtke G (2006), Theng SS (2014), Theng SS (2014)	8
SEM1	0	PSMB4	2	affinity chromatography technology	Wei SJ (2008)	1
NUB1	2	SNCAIP	2	two hybrid, affinity chromatography technology, two hybrid	Tanji K (2006), Tanji K (2006), Tanji K (2007)	3
AIPL1	3	UBD	0	affinity chromatography technology	Bett JS (2012)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
AIPL1	3	NUB1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Akey DT (2002), Akey DT (2002), Bett JS (2012), Kanaya K (2004), Kanaya K (2004), Kanaya K (2004), Akey DT (2004)	7
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBC	7	FAT1	12	pull down	Nathan JA (2013)	1
RNF168	0	NUB1	2	affinity chromatography technology	Hein MY (2015)	1
NUB1	2	PSMD4	1	pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kamitani T (2001), Rani N (2012), Rani N (2012), Rani N (2012), Tanji K (2005), Tanji K (2005), Jeong YY (2016), Jeong YY (2016)	8
TRIM25	5	NUB1	2	affinity chromatography technology	Choudhury NR (2017)	1
VAV1	2	NUB1	2	affinity chromatography technology	Huttlin EL (2017)	1
UFD1	1	PSMD2	2	affinity chromatography technology	Chen M (2011)	1
VCP	6	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Arrojo E Drigo R (2013), McNeill H (2004)	2
SEM1	0	NUB1	2	affinity chromatography technology	Besche HC (2014)	1
EGLN3	0	PSMD2	2	affinity chromatography technology	Rodriguez J (2016)	1
PSMB4	2	UBD	0	affinity chromatography technology	Schmidtke G (2006)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
TERF1	1	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Jeong YY (2016), Jeong YY (2016)	2
PSMD2	2	COPB1	0	biochemical	Wan C (2015)	1
PSMD4	1	NEDD8	0	pull down	Kamitani T (2001)	1
UFD1	1	TP53	0	two hybrid	Vinayagam A (2011)	1
NEDD8	0	HSPA4	3	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1
GSK3B	1	MAPT	1	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shimura H (2004), Wang JZ (1998), Richet E (2012), Richet E (2012), Schneider A (1999), Kawakami F (2011), Kawakami F (2011), Zheng-Fischhoefer Q (1998), Virdee K (2007), Liu F (2002), Sadik G (2009), Sasaki K (2009), Liu F (2006), Watcharasit P (2002)	14
NUB1	2	UBE2K	0	two hybrid	Tanji K (2006)	1
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
FAT1	12	NUB1	2	affinity chromatography technology	Bett JS (2012)	1
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
SEM1	0	PSMD4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baillat D (2005), Krogan NJ (2004), Krogan NJ (2004)	3
SEM1	0	NEDD8	0	affinity chromatography technology	Besche HC (2014)	1
TP53	0	UBD	0	affinity chromatography technology, affinity chromatography technology	Li T (2011), Theng SS (2014)	2
SEM1	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Besche HC (2014), Besche HC (2014)	2
PSMB4	2	PSMD2	2	biochemical, biochemical, pull down	Havugimana PC (2012), Wan C (2015), Sun S (2017)	3
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
PSMB4	2	NUB1	2	affinity chromatography technology	Schmidtke G (2006)	1
TERF1	1	NUB1	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Jeong YY (2016), Jeong YY (2016), Jeong YY (2016), Jeong YY (2016), Jeong YY (2016)	5
GSK3B	1	SNCAIP	2	enzymatic study, affinity chromatography technology	Avraham E (2005), Avraham E (2005)	2
SEM1	0	UBC	7	affinity chromatography technology	Besche HC (2014)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
PSMB4	2	PSMD4	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
SF3B4	2	NUB1	2	two hybrid	Rolland T (2014)	1
TRIM25	5	SF3B4	2	affinity chromatography technology	Choudhury NR (2017)	1
NUB1	2	PSMD2	2	pull down	Rani N (2012)	1
COPB1	0	NUB1	2	two hybrid	Wang J (2011)	1
UBC	7	COPB1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Xu P (2017)	2
NUB1	2	UBC	7	pull down, affinity chromatography technology	Nakayasu ES (2013), Nakayasu ES (2013)	2
UBC	7	UFD1	1	pull down, x-ray crystallography, affinity chromatography technology, pull down	Nathan JA (2013), Park S (2005), Bish RA (2007), Zhang X (2017)	4
EGLN3	0	NEDD8	0	affinity chromatography technology	Rodriguez J (2016)	1
NUB1	2	VCP	6	affinity chromatography technology, pull down, pull down	Liu S (2013), Liu S (2013), Liu S (2013)	3
EGLN3	0	NUB1	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	COPB1	0	affinity chromatography technology	Rodriguez J (2016)	1
GSK3B	1	HSPA4	3	enzymatic study, pull down	Muller P (2012), Kawakami F (2011)	2
PSMD4	1	UBD	0	two hybrid, pull down, pull down	Rani N (2012), Rani N (2012), Rani N (2012)	3
UFD1	1	NUB1	2	pull down	Liu S (2013)	1
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
NEDD8	0	NUB1	2	pull down, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid	Kamitani T (2001), Liu G (2010), Liu G (2010), Norman JA (2006), Tanaka T (2003), Tanaka T (2003), Tanji K (2006), Tanji K (2007)	8
TP53	0	NUB1	2	affinity chromatography technology, affinity chromatography technology	Liu G (2010), Liu G (2010)	2
MAPT	1	NUB1	2	affinity chromatography technology, affinity chromatography technology	Richet E (2012), Richet E (2012)	2
TP53	0	PSMD4	1	affinity chromatography technology, pull down	Kulikov R (2010), Sparks A (2014)	2
TRIM25	5	PSMD2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
PSMD4	1	HSPA4	3	affinity chromatography technology	Andersen KM (2009)	1
AIPL1	3	HSPA4	3	biochemical	Hidalgo-de-Quintana J (2008)	1
MAPT	1	UBC	7	affinity chromatography technology	Mesco ER (1991)	1
HSPA4	3	NUB1	2	biochemical	Hidalgo-de-Quintana J (2008)	1
MAPT	1	HSPA4	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Petrucelli L (2004), Kawakami F (2011), Jinwal UK (2012), Jinwal UK (2012), Jinwal UK (2012)	5
ECT2	2	TP53	0	affinity chromatography technology	Woods NT (2012)	1
FANCA	5	NUB1	2	two hybrid	Reuter TY (2003)	1
EGLN3	0	ECT2	2	affinity chromatography technology	Rodriguez J (2016)	1
SEM1	0	UFD1	1	affinity chromatography technology	Besche HC (2014)	1
TERF1	1	HSPA4	3	affinity chromatography technology	Giannone RJ (2010)	1
EGLN3	0	GSK3B	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PSMD4	1	affinity chromatography technology	Rodriguez J (2016)	1
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5