PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BMP4	0	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
PCK2	3	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
ALDH1B1	2	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF785	0	ZNF747	2	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	GLI3	10	affinity chromatography technology	Rodriguez J (2016)	1
ZNF263	2	ZNF446	1	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
PRPF31	0	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
OVOL1	2	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
ZNF785	0	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
SUFU	2	SUFU	2	pull down	Stone DM (1999)	1
EGLN3	0	ALDH1B1	2	affinity chromatography technology	Rodriguez J (2016)	1
SUFU	2	GLI3	10	pull down	Stone DM (1999)	1
UBE3D	0	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
SUFU	2	RCN3	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
SUFU	2	GLIS3	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), ZeRuth GT (2011), ZeRuth GT (2015)	3
ZBTB46	7	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC25C	0	SUFU	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016), Huttlin EL (2017)	3
TTLL3	0	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LOXL3	0	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
STK36	7	SUFU	2	imaging technique	Chen TC (2014)	1
ZBTB46	7	FBXL17	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZFC3H1	6	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
FBXL17	4	GLI1	3	affinity chromatography technology	Raducu M (2016)	1
GLI2	4	STK36	7	affinity chromatography technology	Murone M (2000)	1
LDLRAD4	1	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF263	2	SUFU	2	two hybrid	Rual JF (2005)	1
BFSP2	1	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
FBXL17	4	SUFU	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Tan MK (2013), Raducu M (2016), Raducu M (2016), Raducu M (2016), Raducu M (2016), Raducu M (2016)	6
LRRC36	2	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
SUFU	2	SAP18	1	affinity chromatography technology	McCallum SA (2006)	1
SUFU	2	PEX26	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
NFATC3	2	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
QPRT	2	SUFU	2	two hybrid	Rual JF (2005)	1
GLI3	10	SAP18	1	genetic interference	Cheng SY (2002)	1
NR2E1	0	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GLI1	3	STK36	7	affinity chromatography technology, imaging technique, imaging technique	Murone M (2000), Murone M (2000), Chen TC (2014)	3
EGLN3	0	SUFU	2	affinity chromatography technology	Rodriguez J (2016)	1
SUFU	2	ZNF747	2	two hybrid, two hybrid, affinity chromatography technology	Ravasi T (2010), Rolland T (2014), Huttlin EL (2017)	3
SUFU	2	ZNF764	2	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
LOXL3	0	EDEM1	3	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	GLI2	4	affinity chromatography technology	Rodriguez J (2016)	1
SUFU	2	MID1IP1	0	two hybrid	Rual JF (2005)	1
SUFU	2	HDX	1	two hybrid	Ravasi T (2010)	1
EGLN3	0	NFATC3	2	affinity chromatography technology	Rodriguez J (2016)	1
LIPT1	1	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUFU	2	ZNF446	1	two hybrid	Rual JF (2005)	1
SUFU	2	GLI2	4	pull down	Stone DM (1999)	1
EGLN3	0	MID1IP1	0	affinity chromatography technology	Rodriguez J (2016)	1
NXPH3	2	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GLI3	10	STK36	7	affinity chromatography technology, imaging technique	Murone M (2000), Chen TC (2014)	2
EDEM1	3	SUFU	2	affinity chromatography technology	Hein MY (2015)	1
GLI1	3	SUFU	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Stone DM (1999), Stone DM (1999), Kogerman P (1999), Kogerman P (1999), Dunaeva M (2003), Dunaeva M (2003), Dunaeva M (2003), Dunaeva M (2003), ZeRuth GT (2011), Chen TC (2014), Li X (2015), Raducu M (2016)	12
PEX11A	0	SUFU	2	affinity chromatography technology	Huttlin EL (2017)	1
GLI1	3	SAP18	1	affinity chromatography technology, genetic interference	Cheng SY (2002), Cheng SY (2002)	2
FAM90A1	1	SUFU	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2