PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDPK1	0	CARD11	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Lee KY (2005), Lee KY (2005), Vinayagam A (2011)	3
PDPK1	0	BLMH	0	two hybrid	Vinayagam A (2011)	1
G3BP1	4	YWHAQ	0	affinity chromatography technology	Jain S (2016)	1
APP	1	HSPA8	4	affinity chromatography technology	Yamamoto YH (2010)	1
ZDHHC17	1	PDPK1	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
PRKCD	2	PDPK1	0	two hybrid, affinity chromatography technology	Hodgkinson CP (2002), Hodgkinson CP (2002)	2
G3BP1	4	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	PHAX	0	affinity chromatography technology	Kirli K (2015)	1
ZDHHC17	1	SMARCB1	1	two hybrid	Butland SL (2014)	1
XPO1	8	YWHAH	0	biochemical	Kristensen AR (2012)	1
PDPK1	0	LUC7L2	0	two hybrid	Vinayagam A (2011)	1
YWHAQ	0	HSPA8	4	affinity chromatography technology	Jin J (2004)	1
PDPK1	0	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology	Chun J (2002), Chun J (2002)	2
PDPK1	0	ZNF133	3	two hybrid	Vinayagam A (2011)	1
PDPK1	0	MAPK8	3	pull down	Park J (1999)	1
ZC3HC1	1	APP	1	pull down	Olah J (2011)	1
TCAP	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
PDPK1	0	PEA15	0	two hybrid	Vinayagam A (2011)	1
PRKCQ	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), Srivastava R (2010), Shambharkar PB (2007)	3
ILK	0	SERPINA4	0	two hybrid	Vinayagam A (2011)	1
CSK	3	AKT2	1	biochemical	Wan C (2015)	1
MAPK8	3	WDCP	2	affinity chromatography technology	Hein MY (2015)	1
PDPK1	0	SOCS3	0	two hybrid	Vinayagam A (2011)	1
PDPK1	0	TCAP	0	two hybrid	Vinayagam A (2011)	1
PRKCD	2	PRKCB	4	affinity chromatography technology	Varjosalo M (2013)	1
AKT1	1	CSK	3	affinity chromatography technology, biochemical	Lodeiro M (2009), Wan C (2015)	2
SLC9A3R2	8	SGK1	4	pull down, pull down, enzymatic study, pull down, affinity chromatography technology	Chun J (2002), Chun J (2002), Chun J (2002), Yun CC (2002), Yun CC (2002)	5
PDPK1	0	PRKCI	1	two hybrid, pull down	Balendran A (2000), Balendran A (2000)	2
CSK	3	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Rahmouni S (2005), Rahmouni S (2005)	2
PRKCZ	5	AKT2	1	affinity chromatography technology, affinity chromatography technology	Wang J (2008), Wang J (2008)	2
POLDIP2	1	APP	1	pull down	Olah J (2011)	1
XPO1	8	PDPK1	0	affinity chromatography technology	Kirli K (2015)	1
ILK	0	XPO1	8	affinity chromatography technology	So J (2015)	1
XPO1	8	WDCP	2	affinity chromatography technology	Kirli K (2015)	1
SDC2	0	PDPK1	0	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	STRAP	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	PRKACA	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	PNO1	0	affinity chromatography technology	Kirli K (2015)	1
PA2G4	1	AKT1	1	affinity chromatography technology, affinity chromatography technology	Kim CK (2011), Kim CK (2011)	2
AKT1	1	AKT2	1	affinity chromatography technology	Huttlin EL (2017)	1
ILK	0	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Barry FA (2002), Delcommenne M (1998), Persad S (2001), McDonald PC (2008)	4
YWHAH	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
PRKCZ	5	PRKCI	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
WDR5	2	PDPK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
G3BP1	4	STRAP	2	affinity chromatography technology	Jain S (2016)	1
XPO1	8	WDR5	2	affinity chromatography technology	Kirli K (2015)	1
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
PDPK1	0	SMARCB1	1	two hybrid	Vinayagam A (2011)	1
LUC7L2	0	APP	1	pull down	Olah J (2011)	1
MAP3K7	2	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016)	4
PDPK1	0	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Sato S (2002), Heo SR (2009)	2
PDPK1	0	PKN2	6	affinity chromatography technology, two hybrid, pull down	Hodgkinson CP (2002), Balendran A (2000), Balendran A (2000)	3
PDPK1	0	SND1	4	affinity chromatography technology	Behrends C (2010)	1
RPS6KA3	2	PDPK1	0	affinity chromatography technology, imaging technique	Froedin M (2000), Chen TC (2014)	2
AKT2	1	APP	1	pull down	Olah J (2011)	1
PDPK1	0	TBL2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2015), Huttlin EL (2017)	3
PDPK1	0	PRKCQ	3	affinity chromatography technology, affinity chromatography technology	Lee KY (2005), Lee KY (2005)	2
SMARCB1	1	APP	1	pull down	Olah J (2011)	1
YWHAQ	0	PRKCQ	3	affinity chromatography technology, affinity chromatography technology, far western blotting	Meller N (1996), Meller N (1996), Meller N (1996)	3
PRKCQ	3	AKT1	1	pull down, affinity chromatography technology	Bauer B (2001), Bauer B (2001)	2
PDPK1	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Barry FA (2002), Persad S (2001), Lin K (2012), Guo J (2016), Guo J (2016)	5
PDPK1	0	SBF1	15	two hybrid	Vinayagam A (2011)	1
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
PDPK1	0	PKN1	4	two hybrid, pull down	Balendran A (2000), Balendran A (2000)	2
CSK	3	PDPK1	0	two hybrid	Grossmann A (2015)	1
PDPK1	0	SERPINA4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK8	3	MAP3K7	2	affinity chromatography technology, pull down	Sanna MG (2002), Sanna MG (2002)	2
PDPK1	0	PRKCZ	5	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Balendran A (2000), Hodgkinson CP (2002), Hodgkinson CP (2002), Le Good JA (1998), Le Good JA (1998), Le Good JA (1998), Balendran A (2000), Park J (1999)	8
MAPK8	3	HSPA8	4	two hybrid	Vinayagam A (2011)	1
PDPK1	0	FAM213B	0	two hybrid	Vinayagam A (2011)	1
AKT1	1	PKN2	6	two hybrid, affinity chromatography technology	Koh H (2000), Koh H (2000)	2
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
SMARCB1	1	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Foster KS (2006), Foster KS (2006), Foster KS (2006), Foster KS (2006)	4
G3BP1	4	APP	1	pull down	Olah J (2011)	1
PRKCI	1	APP	1	pull down	Olah J (2011)	1
YWHAQ	0	LUC7L2	0	affinity chromatography technology	Ewing RM (2007)	1
PDPK1	0	GIT1	10	two hybrid	Vinayagam A (2011)	1
PDPK1	0	PDPK1	0	enzymatic study, enzymatic study	Froedin M (2000), Caohuy H (2014)	2
PRKCZ	5	YWHAH	0	affinity chromatography technology	Van Der Hoeven PC (2000)	1
PRKCB	4	CARD11	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sommer K (2005), Sommer K (2005), Sommer K (2005), Sommer K (2005)	4
PDPK1	0	APP	1	pull down	Olah J (2011)	1
SND1	4	APP	1	pull down	Olah J (2011)	1
PRKCD	2	PRKCQ	3	affinity chromatography technology	Varjosalo M (2013)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
PDPK1	0	AKT2	1	affinity chromatography technology	Guo J (2016)	1
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
SOCS3	0	MAP3K7	2	affinity chromatography technology	Frobose H (2006)	1
PDPK1	0	SCRN2	4	affinity chromatography technology	Huttlin EL (2017)	1
PRKCD	2	APP	1	pull down	Olah J (2011)	1
SBF1	15	PRKACA	2	affinity chromatography technology	St-Denis N (2016)	1
SOCS3	0	YWHAQ	0	two hybrid	Grossmann A (2015)	1
PDPK1	0	DDIT4	0	two hybrid	Vinayagam A (2011)	1
LUC7L2	0	PEA15	0	two hybrid	Stelzl U (2005)	1
PDPK1	0	PRKACA	2	two hybrid, pull down	Biondi RM (2000), Biondi RM (2000)	2
G3BP1	4	PA2G4	1	biochemical	Kristensen AR (2012)	1
PDPK1	0	G3BP1	4	affinity chromatography technology	Behrends C (2010)	1
PDPK1	0	ILK	0	affinity chromatography technology	Persad S (2001)	1
PDPK1	0	PNO1	0	two hybrid	Vinayagam A (2011)	1
PDPK1	0	POLDIP2	1	two hybrid	Vinayagam A (2011)	1
G3BP1	4	YWHAH	0	affinity chromatography technology	Jain S (2016)	1
APBB3	2	APP	1	pull down, protein complementation assay, affinity chromatography technology	Tanahashi H (1999), Kajiwara Y (2010), Huttlin EL (2017)	3
SGK1	4	PDPK1	0	pull down, pull down, enzymatic study	Chun J (2002), Park J (1999), Jung H (2007)	3
PKN1	4	WDR5	2	imaging technique	Kim JY (2014)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
WDR5	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PDPK1	0	XRCC6	3	two hybrid	Vinayagam A (2011)	1
AKT1	1	PRKCB	4	two hybrid, enzymatic study	Arroyo R (2015), Wu D (2009)	2
PDPK1	0	WDCP	2	two hybrid	Vinayagam A (2011)	1
XPO1	8	PRKCI	1	affinity chromatography technology	Kirli K (2015)	1
ILK	0	ZNF133	3	two hybrid	Vinayagam A (2011)	1
PDPK1	0	PHAX	0	two hybrid	Vinayagam A (2011)	1
SRPK1	2	PDPK1	0	enzymatic study	Varjosalo M (2013)	1
SRPK1	2	LUC7L2	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
SMARCB1	1	XPO1	8	affinity chromatography technology, pull down	Craig E (2002), Craig E (2002)	2
APBB3	2	PDPK1	0	two hybrid	Grossmann A (2015)	1
MAP3K7	2	PDPK1	0	affinity chromatography technology, affinity chromatography technology	Moon G (2015), Moon G (2015)	2
ILK	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
BLMH	0	APP	1	pull down, biochemical	Lefterov IM (2000), Lefterov IM (2000)	2
RPS6KA3	2	HSPA8	4	biochemical	Kristensen AR (2012)	1
PDPK1	0	ZC3HC1	1	two hybrid	Vinayagam A (2011)	1
PRKCQ	3	CARD11	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Srivastava R (2010), Sommer K (2005), Eitelhuber AC (2011), Liu Y (2012), Brenner D (2009)	5
PDPK1	0	XPO7	5	two hybrid	Vinayagam A (2011)	1
PRSS23	1	PDPK1	0	two hybrid	Stelzl U (2005)	1
SRPK1	2	APP	1	pull down	Olah J (2011)	1
PDPK1	0	YWHAH	0	affinity chromatography technology, pull down	Sato S (2002), Sato S (2002)	2
SOCS3	0	APP	1	pull down	Olah J (2011)	1
PDPK1	0	CPA4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDPK1	0	PRKCB	4	pull down	Gao T (2001)	1
PEA15	0	RPS6KA3	2	affinity chromatography technology, pull down, affinity chromatography technology	Vaidyanathan H (2003), Vaidyanathan H (2003), Vaidyanathan H (2003)	3
SGK1	4	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chun J (2004), Chun J (2004)	2
PA2G4	1	SND1	4	affinity chromatography technology	Boldt K (2016)	1
CARD11	4	PRKCD	2	affinity chromatography technology	Liu Y (2012)	1
PDPK1	0	STRAP	2	affinity chromatography technology	Jung H (2007)	1
PRSS23	1	APP	1	pull down	Olah J (2011)	1
PDPK1	0	KATNBL1	0	two hybrid	Vinayagam A (2011)	1
SND1	4	G3BP1	4	pull down, affinity chromatography technology, affinity chromatography technology	Gao X (2010), Gao X (2010), Gao X (2010)	3
WDR5	2	FAM199X	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
PRKCB	4	SDC2	0	enzymatic study	Oh ES (1997)	1
XPO1	8	XPO7	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SGK1	4	PA2G4	1	affinity chromatography technology	Ewing RM (2007)	1
PDPK1	0	FAM199X	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKCZ	5	YWHAQ	0	affinity chromatography technology, pull down, enzymatic study	Van Der Hoeven PC (2000), Van Der Hoeven PC (2000), Van Der Hoeven PC (2000)	3
PDPK1	0	PA2G4	1	affinity chromatography technology	Behrends C (2010)	1
PDPK1	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
PA2G4	1	PKN1	4	affinity chromatography technology	Liu Z (2009)	1
PRKCZ	5	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Doornbos RP (1999), Wang J (2008), Wang J (2008), Joshi J (2008), Joshi J (2008)	5
MAPK8	3	BLMH	0	affinity chromatography technology	Hein MY (2015)	1