PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
CFTR	5	SLC9A3R2	8	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sun F (2000), Sun F (2000), Wang X (2006), Pankow S (2015)	4
KCTD17	0	KCTD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PEX5	2	ECI2	2	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
GFAP	0	APP	1	pull down	Olah J (2011)	1
DECR2	1	APP	1	pull down	Olah J (2011)	1
PDZK1	0	ABCC2	2	two hybrid, pull down, imaging technique	Kocher O (1999), Emi Y (2011), Emi Y (2011)	3
PDZK1	0	SLC17A1	3	two hybrid	Gisler SM (2003)	1
SLC9A3R1	2	AKT1	1	affinity chromatography technology, enzymatic study	Song GJ (2015), Song GJ (2015)	2
PDZK1	0	SCARB1	2	affinity chromatography technology, affinity chromatography technology	Silver DL (2002), Huttlin EL (2017)	2
CFTR	5	BCR	3	affinity chromatography technology	Wang X (2006)	1
PDZK1	0	COLEC12	2	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	SLC22A4	1	two hybrid, pull down	Gisler SM (2003), Gisler SM (2003)	2
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
UBE2I	0	ZBED1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KCTD5	0	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
SLC9A3R2	8	ABCC4	3	pull down	Li C (2007)	1
CFTR	5	ECI2	2	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	CLCN3	1	pull down	Gentzsch M (2003)	1
PDZK1	0	KCTD5	0	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	SLC22A5	1	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	AKT1	1	affinity chromatography technology	Kim H (2014)	1
GFAP	0	PDZK1	0	two hybrid	Rual JF (2005)	1
SLC9A3R1	2	SLC4A7	3	pull down	Park M (2002)	1
COLEC12	2	APP	1	pull down	Olah J (2011)	1
PDZK1	0	APP	1	pull down	Olah J (2011)	1
PDZK1	0	UBE2I	0	two hybrid	Gisler SM (2003)	1
CFTR	5	OTULIN	0	affinity chromatography technology	Pankow S (2015)	1
PDZK1	0	SH2D5	1	affinity chromatography technology	Huttlin EL (2017)	1
ECI2	2	APP	1	pull down	Olah J (2011)	1
CDC37	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Basso AD (2002), Basso AD (2002), Kim H (2014), Sun L (2012)	4
KCTD17	0	KCTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDZK1	0	FRYL	12	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	SLC6A6	1	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	SLC34A1	6	two hybrid, pull down	Gisler SM (2003), Gisler SM (2003)	2
USP3	1	PDZK1	0	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	AKAP10	0	two hybrid, pull down	Gisler SM (2003), Gisler SM (2003)	2
PDZK1	0	ABCC4	3	pull down, affinity chromatography technology	Li C (2007), Huttlin EL (2017)	2
PDZK1	0	SLC4A7	3	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	KLHL24	1	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3R1	2	CLCN3	1	pull down	Gentzsch M (2003)	1
ABCC2	2	SLC9A3R1	2	pull down, pull down, imaging technique	Hegedues T (2003), Karvar S (2014), Karvar S (2014)	3
PTGIR	3	PDZK1	0	two hybrid, affinity chromatography technology	Turner EC (2011), Turner EC (2011)	2
CFTR	5	CDC37	0	affinity chromatography technology	Pankow S (2015)	1
PDZK1	0	KCTD17	0	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	CLCN3	1	pull down, affinity chromatography technology	Gentzsch M (2003), Gentzsch M (2003)	2
PDZK1	0	KCTD2	0	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	CSNK2A2	1	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	GFAP	0	two hybrid	Arroyo R (2015)	1
PDZK1	0	KLHL17	6	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	SLC19A3	2	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3R1	2	SLC9A3	10	affinity chromatography technology	Weinman EJ (2003)	1
PDZK1	0	SLK	2	two hybrid, pull down	Gisler SM (2003), Gisler SM (2003)	2
PDZK1	0	DECR2	1	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	SLC9A3R1	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, unspecified method, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hegedues T (2003), Wang S (1998), Wang S (1998), Moyer BD (2000), Gentzsch M (2003), Hall RA (1998), Short DB (1998), Short DB (1998), Short DB (1998), Park M (2002), Park M (2002), Wang X (2006), Pankow S (2015)	13
PDZK1	0	ASNSD1	2	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	ZBTB5	0	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	SLC9A3	10	two hybrid	Gisler SM (2003)	1
CFTR	5	ABCC4	3	affinity chromatography technology	Li C (2007)	1
ARHGAP17	1	APP	1	pull down	Olah J (2011)	1
PDZK1	0	SLC22A12	0	two hybrid, pull down	Gisler SM (2003), Gisler SM (2003)	2
PDZK1	0	CDK5RAP1	1	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	SLC5A6	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	CFTR	5	enzymatic study, enzymatic study	Ahner A (2013), Gong X (2016)	2
KCTD3	2	SHKBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
PDZK1	0	SHKBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	CDC37	0	enzymatic study	Jakobs A (2007)	1
PEX5	2	DECR2	1	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
PDZK1IP1	0	PDZK1	0	two hybrid, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gisler SM (2003), Pribanic S (2003), Gisler SM (2003), Gisler SM (2003), Pribanic S (2003), Silver DL (2003), Silver DL (2003)	7
PDZK1	0	SLC9A3R1	2	two hybrid, pull down	Gisler SM (2003), Gisler SM (2003)	2
PDZK1	0	FARP2	1	two hybrid, pull down	Gisler SM (2003), Gisler SM (2003)	2
CFTR	5	SLC4A7	3	affinity chromatography technology, affinity chromatography technology	Park M (2002), Park M (2002)	2
PDZK1	0	CFTR	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gentzsch M (2003), Gentzsch M (2003), Wang S (2000), Li C (2007)	4
CDC37	0	GFAP	0	affinity chromatography technology	Li J (2013)	1
PDZK1	0	SLC9A3R2	8	two hybrid	Gisler SM (2003)	1
PDZK1	0	PEX5	2	two hybrid	Rual JF (2005)	1
PDZK1	0	KCTD3	2	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A2	1	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
PDZK1	0	ARHGAP17	1	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	ZBED1	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A2	1	CDC37	0	affinity chromatography technology	Hauri S (2016)	1
PDZK1	0	OTULIN	0	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	CDC37	0	affinity chromatography technology, affinity chromatography technology	Kim H (2014), Kim H (2014)	2
PDZK1	0	ECI2	2	affinity chromatography technology	Huttlin EL (2017)	1
PDZK1	0	BCR	3	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	CDK5RAP1	1	affinity chromatography technology	Huttlin EL (2015)	1
PDZK1	0	SLC1A3	1	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3	10	SLC9A3R2	8	pull down	Yun CH (1998)	1
SLC9A3R1	2	ABCC4	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Li C (2007), Hoque MT (2008), Hoque MT (2008), Hoque MT (2008)	4