PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERBB4	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, pull down	Sundvall M (2008), Sundvall M (2008), Sundvall M (2008), Omerovic J (2007), Omerovic J (2007), Omerovic J (2007)	6
TP53	0	WWOX	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Chang NS (2001), Chang NS (2001), Chang NS (2005), Chang NS (2005), Chang NS (2005)	5
WWOX	3	TNK2	7	pull down, affinity chromatography technology, affinity chromatography technology	Chan W (2009), Mahajan NP (2005), Mahajan NP (2005)	3
ERBB4	5	TP53	0	affinity chromatography technology	Gilmore-Hebert M (2010)	1
ERBB4	5	WWOX	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sundvall M (2012), Feng SM (2009), Abu-Odeh M (2014), Sundvall M (2010)	4
TP53	0	TNK2	7	affinity chromatography technology	Ding G (2013)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
WWOX	3	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Schrock MS (2017), Schrock MS (2017), Schrock MS (2017)	3
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
WWOX	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014)	3