PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NINL	1	SYT17	0	two hybrid	Rual JF (2005)	1
CHMP4A	1	EGFR	5	affinity chromatography technology	Ali N (2013)	1
SYT17	0	SSX2IP	0	two hybrid	Rolland T (2014)	1
MEOX1	0	SYT17	0	two hybrid	Rolland T (2014)	1
SYT17	0	TSC22D4	1	two hybrid	Rual JF (2005)	1
CHMP4A	1	SYT17	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Tsang HT (2006), Rolland T (2014)	3
CEP63	2	SSX2IP	0	bioid	Gupta GD (2015)	1
MID2	1	GMCL1	0	two hybrid	Rolland T (2014)	1
IKZF1	2	SYT17	0	two hybrid	Rolland T (2014)	1
SYT17	0	APP	1	pull down	Olah J (2011)	1
MEOX1	0	MEOX2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYT17	0	GMCL1	0	two hybrid	Rolland T (2014)	1
SYT17	0	CEP70	1	two hybrid	Rolland T (2014)	1
MEOX1	0	NIF3L1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYT17	0	CEP63	2	two hybrid	Rolland T (2014)	1
MEOX1	0	APP	1	pull down	Olah J (2011)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CCDC85B	0	SYT17	0	two hybrid	Rual JF (2005)	1
TRAF2	1	SYT17	0	two hybrid	Rolland T (2014)	1
NIF3L1	0	TSC22D4	1	two hybrid	Rual JF (2005)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
SYT17	0	FAM9B	0	two hybrid	Rolland T (2014)	1
RUNDC3A	2	SYT17	0	two hybrid	Rolland T (2014)	1
TRAF2	1	NIF3L1	0	two hybrid	Rual JF (2005)	1
EGFR	5	SYT17	0	affinity chromatography technology	Yao Z (2017)	1
SYT17	0	NIF3L1	0	two hybrid	Rolland T (2014)	1
CCDC85B	0	CEP70	1	two hybrid	Rual JF (2005)	1
SYT17	0	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APTX	3	SYT17	0	two hybrid	Lim J (2006)	1
CCDC85B	0	NIF3L1	0	two hybrid	Rual JF (2005)	1
SSX2IP	0	NIF3L1	0	two hybrid	Yu H (2011)	1
MID2	1	SYT17	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
MEOX2	2	SYT17	0	two hybrid	Rolland T (2014)	1