PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PEX13	0	PEX7	1	pull down, affinity chromatography technology, affinity chromatography technology	Otera H (2002), Huttlin EL (2015), Huttlin EL (2017)	3
C3AR1	1	PEX13	0	affinity chromatography technology	Huttlin EL (2017)	1
PEX13	0	PEX5	2	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Gould SJ (1996), Otera H (2002), Otera H (2002), Gould SJ (1996), Okumoto K (2011)	5
PEX13	0	SPRR2A	2	pull down	Demetris AJ (2008)	1
PEX19	2	PEX14	2	pull down, two hybrid, two hybrid, biochemical, biochemical	Sacksteder KA (2000), Fransen M (2002), Fransen M (2002), Bharti P (2011), Bharti P (2011)	5
C3AR1	1	LPAR1	1	affinity chromatography technology	Huttlin EL (2017)	1
BTN3A2	0	PEX13	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PEX19	2	PEX13	0	two hybrid, pull down, two hybrid, two hybrid, unspecified method	Sacksteder KA (2000), Sacksteder KA (2000), Fransen M (2001), Fransen M (2002), Schueller N (2010)	5
TRAF1	0	PEX13	0	affinity chromatography technology	Huttlin EL (2017)	1
LPAR1	1	PEX13	0	affinity chromatography technology	Huttlin EL (2017)	1
PEX13	0	PEX14	2	pull down, pull down, two hybrid, biochemical	Otera H (2002), Otera H (2002), Fransen M (2002), Bharti P (2011)	4
PEX7	1	PEX5	2	affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology	Dodt G (2001), Dodt G (2001), Dodt G (2001), Otera H (2002), Okumoto K (2011)	5
PEX14	2	PEX7	1	pull down	Shimizu N (1999)	1
PEX13	0	PEX13	0	two hybrid	Fransen M (2002)	1
PEX14	2	PEX5	2	two hybrid, pull down, pull down, pull down, pull down, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical	Okumoto K (2000), Okumoto K (2000), Otera H (2002), Otera H (2002), Shimizu N (1999), Fransen M (2002), Fransen M (2002), Fransen M (2002), Will GK (1999), Will GK (1999), Will GK (1999), Okumoto K (2011), Bharti P (2011), Bharti P (2011)	14