PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
DERL2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012)	3
SSR1	1	ATP5C1	0	biochemical	Wan C (2015)	1
ATP5C1	0	SERPINA1	1	two hybrid	Wang J (2011)	1
ALDH2	2	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	SSR1	1	affinity chromatography technology	Pankow S (2015)	1
SSR1	1	SERPINA1	1	affinity chromatography technology	Nagasawa K (2007)	1
SDC2	0	SERPINA1	1	two hybrid	Wang J (2011)	1
CFTR	5	SERPINA1	1	affinity chromatography technology	Pankow S (2015)	1
FN1	17	SERPINA1	1	affinity chromatography technology	Moussavi-Harami SF (2013)	1
GSDMB	1	SERPINA1	1	two hybrid	Wang J (2011)	1
CANX	4	SERPINA1	1	affinity chromatography technology	Nagasawa K (2007)	1
RAP2A	0	SERPINA1	1	two hybrid	Wang J (2008)	1
CFTR	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meacham GC (1999), Younger JM (2004), Fuller W (2000), Rubenstein RC (2000), Matsumura Y (2011), Goldstein RF (2007), Goldstein RF (2007), Meacham GC (2001), Meacham GC (2001), Wang X (2006), Matsumura Y (2013), Zaman K (2006), Pankow S (2015)	13
HSPA5	0	LAMTOR5	1	biochemical	Havugimana PC (2012)	1
ERLEC1	1	HSPA5	0	affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Yanagisawa K (2010)	2
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
SERPINA1	1	SRP54	0	affinity chromatography technology	Kadowaki H (2015)	1
CFTR	5	HSPA5	0	affinity chromatography technology	Pankow S (2015)	1
FBXO2	0	SERPINA1	1	affinity chromatography technology	Wen JH (2015)	1
MAPK6	1	SERPINA1	1	affinity chromatography technology	Huttlin EL (2017)	1
ECHS1	2	SERPINA1	1	two hybrid	Wang J (2011)	1
HSPA5	0	SERPINA1	1	affinity chromatography technology	Dersh D (2014)	1
ERLEC1	1	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012)	4
CFTR	5	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun F (2006), Sun F (2006), Younger JM (2006), Wang B (2008), Pankow S (2015)	5
SERPINA1	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Feng L (2017), Feng L (2017)	2
FN1	17	SMAD4	9	two hybrid	Wang J (2011)	1
OS9	4	VCP	6	affinity chromatography technology	Tyler RE (2012)	1
GOT1L1	1	SERPINA1	1	affinity chromatography technology	Huttlin EL (2017)	1
KLK3	1	SERPINA1	1	affinity chromatography technology	Christensson A (1990)	1
FN1	17	ATP5C1	0	affinity chromatography technology	Humphries JD (2009)	1
SERPINA1	1	ERLEC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Yamaguchi D (2010), Fujimori T (2013)	3
CFTR	5	DERL2	0	affinity chromatography technology	Pankow S (2015)	1
ERLEC1	1	DERL2	0	affinity chromatography technology	Christianson JC (2012)	1
KLK3	1	HSPA5	0	affinity chromatography technology	Huttlin EL (2015)	1
OS9	4	DERL2	0	affinity chromatography technology, affinity chromatography technology	Tyler RE (2012), Huang CH (2013)	2
DERL1	2	CANX	4	affinity chromatography technology	You H (2017)	1
DERL1	2	HSPA8	4	affinity chromatography technology	You H (2017)	1
ELANE	0	SERPINA1	1	pull down	Taggart C (2000)	1
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
GDPD1	0	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DERL3	0	SRP54	0	affinity chromatography technology	Kadowaki H (2015)	1
DERL1	2	SRP54	0	affinity chromatography technology, affinity chromatography technology	Kadowaki H (2015), Kadowaki H (2015)	2
UPF3A	2	SERPINA1	1	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	SQSTM1	0	imaging technique, affinity chromatography technology, biochemical	Luciani A (2010), Villella VR (2013), Villella VR (2013)	3
SNX27	5	SERPINA1	1	affinity chromatography technology	Huttlin EL (2017)	1
FN1	17	HSPA5	0	affinity chromatography technology	Humphries JD (2009)	1
SERPINA1	1	SYVN1	2	affinity chromatography technology	Feng L (2017)	1
SDC2	0	FN1	17	pull down	Kusano Y (2000)	1
HSPA8	4	SRP54	0	affinity chromatography technology	Huttlin EL (2017)	1
SERPINA1	1	OS9	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Satoh T (2010), Mikami K (2010), Dersh D (2014)	4
DERL2	0	SRP54	0	affinity chromatography technology, affinity chromatography technology	Kadowaki H (2015), Kadowaki H (2015)	2
ICE2	2	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	VCP	6	affinity chromatography technology	Humphries JD (2009)	1
CFTR	5	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosser MF (2008), Wang X (2006), Pankow S (2015)	3
SERPINA1	1	SMAD4	9	two hybrid	Wang J (2011)	1
SYVN1	2	HSPA5	0	affinity chromatography technology	Wu ZZ (2011)	1
SSR1	1	HSPA5	0	affinity chromatography technology	Nagasawa K (2007)	1
MAPK6	1	SQSTM1	0	affinity chromatography technology	Rodriguez J (2016)	1
DERL1	2	SERPINA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Huang CH (2013), Kadowaki H (2015), Kadowaki H (2015)	4
DERL2	0	SERPINA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Huang CH (2013), Kadowaki H (2015), Kadowaki H (2015)	4
MAPK6	1	ATP5C1	0	affinity chromatography technology	Rodriguez J (2016)	1
PLK2	0	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	CANX	4	affinity chromatography technology, biochemical	Yu CC (2013), Wan C (2015)	2
DDX19B	2	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAMTOR5	1	SERPINA1	1	two hybrid	Fan W (2013)	1
VCP	6	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	LaLonde DP (2011), Khodayari N (2017)	2
HSPA5	0	SQSTM1	0	unspecified method, pull down	Cha-Molstad H (2015), Cha-Molstad H (2015)	2
KLK3	1	FN1	17	imaging technique	Chen TC (2014)	1
HSPA8	4	VCP	6	affinity chromatography technology, biochemical, affinity chromatography technology	Vij N (2006), Havugimana PC (2012), Yu CC (2013)	3
ZNF558	0	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VKORC1	1	SERPINA1	1	two hybrid	Schaafhausen A (2011)	1
FN1	17	HSPA8	4	affinity chromatography technology	Humphries JD (2009)	1
DERL2	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Greenblatt EJ (2011), Huang CH (2013), Christianson JC (2012)	4
OS9	4	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hosokawa N (2008), Christianson JC (2008), Tyler RE (2012)	3
VCP	6	HSPA5	0	affinity chromatography technology	Yu CC (2013)	1
HSPA8	4	SERPINA1	1	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
DERL3	0	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Kadowaki H (2015), Kadowaki H (2015)	2
HSPA5	0	HSPA8	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
ERLEC1	1	OS9	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yanagisawa K (2010), Yanagisawa K (2010), Christianson JC (2012)	3
MAPK6	1	HSPA8	4	affinity chromatography technology	Rodriguez J (2016)	1
FBXO2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
CFTR	5	SNX27	5	affinity chromatography technology	Pankow S (2015)	1
CA8	0	SERPINA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRTN3	2	SERPINA1	1	enzymatic study	Korkmaz B (2002)	1
OS9	4	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Tyler RE (2012), Tyler RE (2012), Iida Y (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015), Schulz J (2017)	8
DERL2	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Bernardi KM (2010), Huang CH (2013), Huang CH (2013), Huang CH (2013), Zhang T (2015)	6
DDX31	1	SERPINA1	1	affinity chromatography technology	Huttlin EL (2017)	1
RCHY1	0	SERPINA1	1	two hybrid	Wang J (2011)	1
MIS12	0	SERPINA1	1	affinity chromatography technology	Hutchins JR (2010)	1