PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SERPINB9	0	PRPF40A	5	two hybrid	Stelzl U (2005)	1
SERPINB9	0	GDF9	2	two hybrid	Stelzl U (2005)	1
SERPINB9	0	EEF1A1	0	two hybrid	Stelzl U (2005)	1
MCM2	3	TUBB2A	2	affinity chromatography technology	Drissi R (2015)	1
TP53	0	TUBB2A	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
CASP10	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
COPS6	0	CDK2	0	affinity chromatography technology	Bennett EJ (2010)	1
SERPINB9	0	ECH1	2	two hybrid	Stelzl U (2005)	1
SERPINB9	0	TUBB2A	2	two hybrid	Stelzl U (2005)	1
CDK2	0	XRCC6	3	enzymatic study, affinity chromatography technology	Diederichs S (2004), So J (2015)	2
BRD7	2	LRIF1	3	two hybrid	Goehler H (2004)	1
CDK2	0	SERPINB9	0	affinity chromatography technology	Neganova I (2011)	1
MCM2	3	SERPINB9	0	affinity chromatography technology	Drissi R (2015)	1
IGSF8	1	XRCC6	3	affinity chromatography technology	Perez-Hernandez D (2013)	1
PRPF40A	5	GAPDH	0	pull down	Ingham RJ (2005)	1
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
EEF1A1	0	GAPDH	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
SERPINB9	0	PLEKHM1	5	two hybrid	Stelzl U (2005)	1
MCM2	3	XRCC6	3	affinity chromatography technology	Drissi R (2015)	1
SERPINB9	0	XRCC6	3	two hybrid	Stelzl U (2005)	1
SERPINB9	0	ERG28	0	two hybrid	Stelzl U (2005)	1
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
SERPINB9	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
XRCC6	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Feki A (2005), Feki A (2005)	2
SERPINB9	0	UNC119	4	two hybrid	Stelzl U (2005)	1
SERPINB9	0	CASP1	1	pull down	Annand RR (1999)	1
SERPINB9	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
CASP8	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
MCM2	3	GAPDH	0	affinity chromatography technology	Drissi R (2015)	1
CDK2	0	GAPDH	0	affinity chromatography technology	Neganova I (2011)	1
SERPINB9	0	GBP2	0	two hybrid	Stelzl U (2005)	1
CASP8	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
CASP10	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
CD81	0	GAPDH	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
MCM2	3	EEF1A1	0	affinity chromatography technology	Drissi R (2015)	1
VAPA	1	SERPINB9	0	affinity chromatography technology	Huttlin EL (2017)	1
ZHX1	1	PRPF40A	5	two hybrid	Goehler H (2004)	1
SERPINB9	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
BRD7	2	TP53	0	affinity chromatography technology, pull down, imaging technique	Drost J (2010), Drost J (2010), Drost J (2010)	3
SERPINB9	0	CCDC90B	2	two hybrid	Stelzl U (2005)	1
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
SERPINB9	0	COPS6	0	two hybrid	Stelzl U (2005)	1
SERPINB9	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
GZMB	0	XRCC6	3	enzymatic study	Song Q (1996)	1
CD81	0	IGSF8	1	affinity chromatography technology	Clark KL (2001)	1
SERPINB9	0	CASP10	1	affinity chromatography technology	Kummer JA (2007)	1
CASP4	1	CDK2	0	affinity chromatography technology	Ewing RM (2007)	1
SERPINB9	0	TRAF5	1	two hybrid	Rolland T (2014)	1
CDK2	0	EEF1A1	0	affinity chromatography technology	Neganova I (2011)	1
SERPINB9	0	TP53	0	two hybrid	Stelzl U (2005)	1
CD81	0	TUBB2A	2	affinity chromatography technology	Perez-Hernandez D (2013)	1
CDK2	0	TUBB2A	2	affinity chromatography technology	Neganova I (2011)	1
SERPINB9	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
TP53	0	GAPDH	0	affinity chromatography technology	Sen N (2008)	1
SERPINB9	0	CASP8	1	affinity chromatography technology	Kummer JA (2007)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
SERPINB9	0	BRD7	2	two hybrid	Stelzl U (2005)	1
SERPINB9	0	MED31	0	two hybrid	Stelzl U (2005)	1
MCM2	3	VAPA	1	affinity chromatography technology	Drissi R (2015)	1
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
CD81	0	SERPINB9	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
SERPINB9	0	CASP4	1	pull down	Annand RR (1999)	1
PRPF40A	5	XRCC6	3	pull down	Ingham RJ (2005)	1
GZMB	0	SERPINB9	0	pull down	Sun J (1996)	1
SERPINB9	0	UBR1	3	two hybrid	Stelzl U (2005)	1
IGSF8	1	SERPINB9	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
EEF1A1	0	CD81	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Perez-Hernandez D (2013), Perez-Hernandez D (2013), Perez-Hernandez D (2013)	3
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
SERPINB9	0	RBM48	1	two hybrid	Stelzl U (2005)	1
SERPINB9	0	GAPDH	0	two hybrid	Stelzl U (2005)	1
GZMB	0	CASP8	1	enzymatic study	Cullen SP (2007)	1
CASP8	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
COPS6	0	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
SERPINB9	0	TLE1	6	two hybrid	Stelzl U (2005)	1